Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors

Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine

(2011) J H McIntosh et al.   GENE THERAPY

Mycophenolate Mofetil Impairs Transduction of Single-Stranded Adeno-Associated Viral Vectors

(2011) Paula S. Montenegro-Miranda et al.   HUMAN GENE THERAPY

Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management

(2010) S. Vincent Rajkumar   AMERICAN JOURNAL OF HEMATOLOGY

Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

(2010) Ian J. Amanna et al.   IMMUNOLOGICAL REVIEWS

Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application

(2010) Paul E Monahan et al.   MOLECULAR THERAPY

Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

(2010) Timothy K MacLachlan et al.   MOLECULAR THERAPY

Structure, Assembly and Homeostatic Regulation of the 26S Proteasome

(2010) Y. Xie   Journal of Molecular Cell Biology

Bortezomib

(2009) Monique P. Curran et al.   DRUGS

Proteasome Inhibitors Decrease AAV2 Capsid derived Peptide Epitope Presentation on MHC Class I Following Transduction

(2009) Jonathan D Finn et al.   MOLECULAR THERAPY

Phase I and Pharmacokinetic Study of Bortezomib in Combination with Idarubicin and Cytarabine in Patients with Acute Myelogenous Leukemia

(2008) E. C. Attar et al.   CLINICAL CANCER RESEARCH

Enhancing transduction of the liver by adeno-associated viral vectors

(2008) A C Nathwani et al.   GENE THERAPY

Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

(2008) H. Gu et al.   MOLECULAR CANCER THERAPEUTICS

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL

Prolonged Susceptibility to Antibody-mediated Neutralization for Adeno-associated Vectors Targeted to the Liver

(2007) Samuel L Murphy et al.   MOLECULAR THERAPY