Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology

Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics

(2021) Archana Gengatharan et al.   CELL

Sex differences in circadian endocrine rhythms: Clinical implications

(2020) Nicolas C. Nicolaides et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Circadian and sleep dysfunction in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   AGEING RESEARCH REVIEWS

Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease

(2020) Mazel Mihardja et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases

(2020) Dongmei Chen et al.   Biomolecules

Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations

(2020) William D. Todd et al.   Nature Communications

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

(2019) Md. Farhad Hossain et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammation and Glial Phenotypic Changes in Alpha-Synucleinopathies

(2019) Violetta Refolo et al.   Frontiers in Cellular Neuroscience

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities

(2019) Jie Liu et al.   Frontiers in Molecular Neuroscience

Autophagy-Mediated Secretory Pathway is Responsible for Both Normal and Pathological Tau in Neurons

(2019) Seokjo Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin alleviates circadian system disruption induced by chronic shifts of the light‐dark cycle in Octodon degus

(2019) Beatriz Bano‐Otalora et al.   JOURNAL OF PINEAL RESEARCH

The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease

(2019) Jung Goo Lee et al.   Brain Sciences

Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics

(2018) Brendan P. Lucey et al.   ANNALS OF NEUROLOGY

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction

(2018) He-Jin Lee et al.   Cell Death & Disease

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

mTOR signaling regulates central and peripheral circadian clock function

(2018) Chidambaram Ramanathan et al.   PLoS Genetics

Autophagy Modulators and Neuroinflammation

(2018) Kyoung Sang Cho et al.   CURRENT MEDICINAL CHEMISTRY

Pimozide reduces toxic forms of tau in TauC3 mice via 5′ adenosine monophosphate-activated protein kinase-mediated autophagy

(2017) Young Doo Kim et al.   JOURNAL OF NEUROCHEMISTRY

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities

(2017) Maxime J. Parent et al.   JOURNAL OF NEUROSCIENCE

Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

(2017) Reddy Peera Kommaddi et al.   JOURNAL OF NEUROSCIENCE

Tau Protein Role in Sleep-Wake Cycle

(2017) Jose L. Cantero et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases

(2016) Lynn Marie Trotti et al.   Current Neurology and Neuroscience Reports

Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway

(2016) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

(2016) Roman V. Kondratov et al.   Aging-US

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

(2016) Rohini V. Khapre et al.   Aging-US

mTor mediates tau localization and secretion: Implication for Alzheimer's disease

(2015) Zhi Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antemortem Prediction of Braak Stage

(2015) Jesper O.E. Carlson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

What does it take to produce a breakthrough drug?

(2015) Dirk Calcoen et al.   NATURE REVIEWS DRUG DISCOVERY

Progressive age-related changes in sleep and EEG profiles in the PLB1Triple mouse model of Alzheimer’s disease

(2015) Amar Jyoti et al.   NEUROBIOLOGY OF AGING

Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice

(2015) Ke Ding et al.   NEUROCHEMISTRY INTERNATIONAL

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

The Melatonin–N,N-Dibenzyl(N-methyl)amine Hybrid ITH91/IQM157 Affords Neuroprotection in an in Vitro Alzheimer’s Model via Hemo-oxygenase-1 Induction

(2014) Izaskun Buendia et al.   ACS Chemical Neuroscience

Diurnal rhythms of autophagy: Implications for cell biology and human disease

(2014) Uma M. Sachdeva et al.   Autophagy

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

(2014) Per Nilsson et al.   BIOESSAYS

Beneficial effects of melatonin in a rat model of sporadic Alzheimer’s disease

(2014) Ekaterina A. Rudnitskaya et al.   BIOGERONTOLOGY

Differential role of melatonin in restoration of age-induced alterations in daily rhythms of expression of various clock genes in suprachiasmatic nucleus of male Wistar rats

(2014) Ushodaya Mattam et al.   BIOGERONTOLOGY

The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling

(2014) D Liu et al.   CELL DEATH AND DIFFERENTIATION

Longevity, aging and rapamycin

(2014) Dan Ehninger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chronic exposure to aluminum and melatonin through the diet: Neurobehavioral effects in a transgenic mouse model of Alzheimer disease

(2014) Celeste Di Paolo et al.   FOOD AND CHEMICAL TOXICOLOGY

Acute melatonin treatment alters dendritic morphology and circadian clock gene expression in the hippocampus of Siberian Hamsters

(2014) Tomoko Ikeno et al.   HIPPOCAMPUS

Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders

(2014) Moshe Laudon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

(2014) Anorut Jenwitheesuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases

(2013) Xiaozhen Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

(2013) Arnaud François et al.   Journal of Neuroinflammation

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome

(2013) Andrea Corrales et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

How to fix a broken clock

(2013) Analyne M. Schroeder et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Circadian System in Alzheimer’s Disease: Disturbances, Mechanisms, and Opportunities

(2012) Andrew N. Coogan et al.   BIOLOGICAL PSYCHIATRY

Circadian System Functionality, Hippocampal Oxidative Stress, and Spatial Memory in the APPswe/PS1dE9 Transgenic Model of Alzheimer Disease: Effects of Melatonin or Ramelteon

(2012) Beatriz Baño Otalora et al.   CHRONOBIOLOGY INTERNATIONAL

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   JOURNAL OF PINEAL RESEARCH

The circadian clock and pathology of the ageing brain

(2012) Anna A. Kondratova et al.   NATURE REVIEWS NEUROSCIENCE

Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells

(2012) Natasa Dragicevic et al.   NEUROPHARMACOLOGY

Current and future treatments for Alzheimer’s disease

(2012) Konstantina G. Yiannopoulou et al.   Therapeutic Advances in Neurological Disorders

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Current and Emerging Drug Treatment Options for Alzheimerʼs Disease

(2011) Nathan Herrmann et al.   DRUGS

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Melatonin: Both master clock output and internal time-giver in the circadian clocks network

(2011) Paul Pevet et al.   JOURNAL OF PHYSIOLOGY-PARIS

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

(2011) Chia-Fu Chang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin increases dendritogenesis in the hilus of hippocampal organotypic cultures

(2011) A. Domínguez-Alonso et al.   JOURNAL OF PINEAL RESEARCH

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

(2011) Song-In Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

(2011) Yoelvis García-Mesa et al.   NEUROBIOLOGY OF AGING

Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus

(2011) R. Cao et al.   NEUROSCIENCE

Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1

(2011) Bettina Platt et al.   PLoS One

Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice

(2011) T. A. Bedrosian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of ramelteon in the treatment of sleep disorders

(2011) David Neubauer   Neuropsychiatric Disease and Treatment

What can we learn from study of Alzheimer's disease in patients with Down syndrome for early-onset Alzheimer's disease in the general population?

(2011) Robyn A Wallace et al.   Alzheimers Research & Therapy

Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock

(2010) Rohini V. Khapre et al.   ANNALS OF MEDICINE

AKT and TOR Signaling Set the Pace of the Circadian Pacemaker

(2010) Xiangzhong Zheng et al.   CURRENT BIOLOGY

Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

(2010) Daniel P. Cardinali et al.   Current Neuropharmacology

Alzheimer's disease genetics: current knowledge and future challenges

(2010) Paul Hollingworth et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Mammalian Target of Rapamycin Signaling Modulates Photic Entrainment of the Suprachiasmatic Circadian Clock

(2010) R. Cao et al.   JOURNAL OF NEUROSCIENCE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Melatonin Fails to Improve Sleep or Agitation in Double-Blind Randomized Placebo-Controlled Trial of Institutionalized Patients With Alzheimer Disease

(2009) Philip R. Gehrman et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Animal models reveal role for tau phosphorylation in human disease

(2009) Jürgen Götz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

(2009) María Isabel Fernández-Bachiller et al.   ChemMedChem

A 25-week, open-label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer’s disease: a post hoc analysis

(2009) Martin R. Farlow et al.   CURRENT MEDICAL RESEARCH AND OPINION

Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats

(2009) Michal Zeman et al.   JOURNAL OF HYPERTENSION

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Usual sleep duration and cognitive function in older adults in Spain

(2009) RAQUEL FAUBEL et al.   JOURNAL OF SLEEP RESEARCH

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

A New Tacrine–Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

(2009) Carlos Spuch et al.   NEUROTOXICITY RESEARCH

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease

(2009) Tania García et al.   TOXICOLOGY

REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease

(2008) Kirstie N. Anderson et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities

(2008) Rixt F. Riemersma-van der Lek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal ‘clock’ gene expression in striatal neurons in vitro

(2008) Marta Imbesi et al.   JOURNAL OF PINEAL RESEARCH

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Therapeutic Strategies for Alzheimer’s Disease

(2008) Donna M. Barten et al.   MOLECULAR NEUROBIOLOGY

Hope in Alzheimer's fight emerges from unexpected places

(2008) Trisha Gura   NATURE MEDICINE

Melatonin inhibits amphetamine-induced increase in α-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK–N–SH cells

(2008) Sirirat Klongpanichapak et al.   NEUROSCIENCE LETTERS

Efficacy of Memantine on Behavioral and Psychological Symptoms Related to Dementia: A Systematic Meta-Analysis

(2007) Ian D Maidment et al.   ANNALS OF PHARMACOTHERAPY