Ginseng gintonin, aging societies, and geriatric brain diseases

Autophagy in Astrocytes and its Implications in Neurodegeneration

(2020) Katherine Sung et al.   JOURNAL OF MOLECULAR BIOLOGY

Ginseng Gintonin Contains Ligands for GPR40 and GPR55

(2020) Yeon-Jin Cho et al.   MOLECULES

Hung-up Knee Jerk in Huntington’s Disease

(2020) Tatsuya Fukumoto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Normative data for Emotion Hexagon test and frequency of impairment in behavioral variant frontotemporal dementia, Alzheimer’s disease and Huntington’s disease

(2020) Asmus Vogel et al.   Applied Neuropsychology-Adult

LPA 1 , LPA 2 , LPA 4 , and LPA 6 receptor expression during mouse brain development

(2019) Olga Suckau et al.   DEVELOPMENTAL DYNAMICS

Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington’s disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors

(2019) Minhee Jang et al.   BRAIN BEHAVIOR AND IMMUNITY

Animal Models for Parkinson’s Disease Research: Trends in the 2000s

(2019) Kyohei Kin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gintonin Administration is Safe and Potentially Beneficial in Cognitively Impaired Elderly

(2018) Jangsup Moon et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway

(2018) Moreno-Fernandez Roman Dario et al.   Current Neuropharmacology

Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway

(2018) Min Gi Jo et al.   MOLECULAR NEUROBIOLOGY

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

OUP accepted manuscript

(2018)   PAIN MEDICINE

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

(2018) Katherine G. Akers et al.   STEM CELLS

Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

(2018) Pedro Baptista et al.   Frontiers in Neuroanatomy

Panax ginseng as an adjuvant treatment for Alzheimer's disease

(2018) Hyeon-Joong Kim et al.   Journal of Ginseng Research

Gintonin-mediated release of astrocytic vascular endothelial growth factor protects cortical astrocytes from hypoxia-induced cell damages

(2018) Sun-Hye Choi et al.   Journal of Ginseng Research

Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson’s Disease via Lysophosphatidic Acid Receptors

(2018) Jong Hee Choi et al.   Frontiers in Pharmacology

Autophagy in Age-Associated Neurodegeneration

(2018) Athanasios Metaxakis et al.   Cells

Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions

(2018) Sung Min Nam et al.   GERONTOLOGY

Gintonin, a Ginseng-Derived Lysophosphatidic Acid Receptor Ligand, Attenuates Alzheimer's Disease-Related Neuropathies: Involvement of Non-Amyloidogenic Processing

(2018) Sung Hee Hwang et al.   JOURNAL OF ALZHEIMERS DISEASE

Gintonin, a Ginseng-Derived Exogenous Lysophosphatidic Acid Receptor Ligand, Protects Astrocytes from Hypoxic and Re-oxygenation Stresses Through Stimulation of Astrocytic Glycogenolysis

(2018) Sun-Hye Choi et al.   MOLECULAR NEUROBIOLOGY

Gintonin stimulates autophagic flux in primary cortical astrocytes

(2018) Md. Ataur Rahman et al.   Journal of Ginseng Research

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Gintonin attenuates depressive-like behaviors associated with alcohol withdrawal in mice

(2017) Hyeon-Joong Kim et al.   JOURNAL OF AFFECTIVE DISORDERS

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

(2017) Veronica Lindström et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Bioactive lipids in gintonin-enriched fraction from ginseng

(2017) Hee-Jung Cho et al.   Journal of Ginseng Research

Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease

(2017) Elisabeth Singer et al.   Scientific Reports

Plant Lysophosphatidic Acids: A Rich Source for Bioactive Lysophosphatidic Acids and Their Pharmacological Applications

(2016) Byung-Hwan Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Effects of gintonin-enriched fraction on hippocampal cell proliferation in wild-type mice and an APPswe/PSEN-1 double Tg mouse model of Alzheimer's disease

(2016) Hyeon-Joong Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Gintonin enhances performance of mice in rotarod test: Involvement of lysophosphatidic acid receptors and catecholamine release

(2016) Byung-Hwan Lee et al.   NEUROSCIENCE LETTERS

Epidemiology of Parkinson's disease

(2016) A. Elbaz et al.   REVUE NEUROLOGIQUE

Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling

(2016) Sung-Hee Hwang et al.   Journal of Ginseng Research

Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration

(2016) Sungmin Kim et al.   Journal of Ginseng Research

Potentiation of Glucose-stimulated Insulin Secretion by the GPR40–PLC–TRPC Pathway in Pancreatic β-Cells

(2016) Hodaka Yamada et al.   Scientific Reports

Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses

(2015) Hoyong Park et al.   JOURNAL OF NEUROPHYSIOLOGY

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

(2015) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer’s Disease

(2015) Hyeon-Joong Kim et al.   MOLECULES AND CELLS

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

Huntington Disease

(2015) Praveen Dayalu et al.   NEUROLOGIC CLINICS

Gintonin stimulates gliotransmitter release in cortical primary astrocytes

(2015) Hyunsook Kim et al.   NEUROSCIENCE LETTERS

A brief method for preparation of gintonin-enriched fraction from ginseng

(2015) Sun-Hye Choi et al.   Journal of Ginseng Research

Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions

(2015) Sun-Hye Choi et al.   Frontiers in Pharmacology

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Physical exercise ameliorates the reduction of neural stem cell, cell proliferation and neuroblast differentiation in senescent mice induced by D-galactose

(2014) Sung Min Nam et al.   BMC NEUROSCIENCE

Autophagy and the immune function in aging

(2014) Ana Maria Cuervo et al.   CURRENT OPINION IN IMMUNOLOGY

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Effects of Sucrose Stearate Addition on the Quality Improvement of Ready-To-Eat Samgyetang During Storage at 25℃

(2014) Endy Triyannanto et al.   Korean Journal for Food Science of Animal Resources

D-galactose-induced mitochondrial DNA oxidative damage in the auditory cortex of rats

(2014) ZHENGDE DU et al.   Molecular Medicine Reports

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arterial Stiffness and β-Amyloid Progression in Nondemented Elderly Adults

(2014) Timothy M. Hughes et al.   JAMA Neurology

Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors

(2014) Seung-Yeol Nah   Frontiers in Physiology

The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism

(2014) Tsutomu Tomita et al.   Frontiers in Endocrinology

Valeriana officinalis extract and its main component, valerenic acid, ameliorate d-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation

(2013) Sung Min Nam et al.   EXPERIMENTAL GERONTOLOGY

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

(2013) Lars Brichta et al.   TRENDS IN NEUROSCIENCES

Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

(2013) Nady Braidy et al.   Translational Neurodegeneration

Lysophosphatidylinositol signalling: New wine from an old bottle

(2012) Roberto Piñeiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

GPR40: A therapeutic target for mediating insulin secretion

(2012) XIAO-TAO FENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: Involvement of autotaxin inhibition

(2012) SUNG HEE HWANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Charles F Burant et al.   LANCET

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity

(2012) Sung Hee Hwang et al.   MOLECULES AND CELLS

Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing

(2012) Young-Soo Kim et al.   Journal of Ginseng Research

An Edible Gintonin Preparation from Ginseng

(2012) Sun-Hye Choi et al.   Journal of Ginseng Research

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifespan brain activity, β-amyloid, and Alzheimer's disease

(2011) William J. Jagust et al.   TRENDS IN COGNITIVE SCIENCES

Neurodegenerative processes in Huntington's disease

(2011) D Bano et al.   Cell Death & Disease

A Simple Method for the Preparation of Crude Gintonin from Ginseng Root, Stem, and Leaf

(2011) Mi-Kyung Pyo et al.   Journal of Ginseng Research

Novel Glycolipoproteins from Ginseng

(2011) Mi-Kyung Pyo et al.   Journal of Ginseng Research

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells

(2010) S. Oka et al.   JOURNAL OF BIOCHEMISTRY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

(2010) Isaac Túnez et al.   MOLECULES

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purple Sweet Potato Color Alleviates D-galactose-induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C-mediated Apoptosis

(2009) Jun Lu et al.   BRAIN PATHOLOGY

Isolation and expression analysis of a novel major latex-like protein (MLP151) gene from Panax ginseng

(2009) Hua Sun et al.   MOLECULAR BIOLOGY REPORTS

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

(2008) T. Pan et al.   BRAIN

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

The coming acceleration of global population ageing

(2008) Wolfgang Lutz et al.   NATURE

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA