Clock at the Core of Cancer Development

Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway

(2020) Guojun Yang et al.   CANCER SCIENCE

Outdoor light at night at residences and breast cancer risk in Canada

(2020) Jennifer Ritonja et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Circadian Clocks Make Metabolism Run

(2020) Flore Sinturel et al.   JOURNAL OF MOLECULAR BIOLOGY

Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy

(2020) Roger J. W. Hill et al.   PLoS Computational Biology

Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction

(2020) Nikkhil Velingkaar et al.   AGING CELL

BMAL1 knockdown triggers different colon carcinoma cell fates by altering the delicate equilibrium between AKT/mTOR and P53/P21 pathways

(2020) Yuan Zhang et al.   Aging-US

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

(2020) Sujeewa S. Lellupitiyage Don et al.   PLoS One

Crosstalk between metabolism and circadian clocks

(2019) Hans Reinke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

(2019) Tsuyoshi Oshima et al.   Science Advances

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism

(2019) Amandine Verlande et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

(2019) Yool Lee et al.   PLOS BIOLOGY

Radiation chronotherapy—clinical impact of treatment time-of-day: a systematic review

(2019) Dorela D. Shuboni-Mulligan et al.   JOURNAL OF NEURO-ONCOLOGY

IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life?

(2019) Thomas C. Erren et al.   Journal of Occupational Medicine and Toxicology

Light Pollution, Circadian Photoreception, and Melatonin in Vertebrates

(2019) Maja Grubisic et al.   Sustainability

Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist

(2019) Tia Tyrsett Kuo et al.   Frontiers in Genetics

Caloric restriction effects on liver mTOR signaling are time-of-day dependent

(2018) Richa Tulsian et al.   Aging-US

Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study

(2018) Louise E Johns et al.   BRITISH JOURNAL OF CANCER

The immune system as a chronotoxicity target of the anticancer mTOR inhibitor everolimus

(2018) Narin Ozturk et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian nutritional behaviours and cancer risk: New insights from the NutriNet-santé prospective cohort study: Disclaimers

(2018) Bernard Srour et al.   INTERNATIONAL JOURNAL OF CANCER

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

(2018) Dong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

(2018) Wenjun Deng et al.   Cell Reports

mTOR signaling regulates central and peripheral circadian clock function

(2018) Chidambaram Ramanathan et al.   PLoS Genetics

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

(2018) Youqiong Ye et al.   Cell Systems

Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma

(2018) Leonardo Vinícius Monteiro de Assis et al.   Frontiers in Oncology

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

(2018) Gabriele Sulli et al.   NATURE

Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases

(2018) Gabriele Sulli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

mTOR Signaling, Translational Control, and the Circadian Clock

(2018) Ruifeng Cao   Frontiers in Genetics

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

(2018) Rong Wu et al.   Cell Metabolism

Calorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism

(2018) Kuldeep Makwana et al.   FASEB JOURNAL

The emerging link between cancer, metabolism, and circadian rhythms

(2018) Selma Masri et al.   NATURE MEDICINE

Outdoor Light at Night and Breast Cancer Incidence in the Nurses’ Health Study II

(2017) Peter James et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation

(2017) Amol Chaudhari et al.   MOLECULAR BIOLOGY OF THE CELL

Systems Chronotherapeutics

(2017) Annabelle Ballesta et al.   PHARMACOLOGICAL REVIEWS

CYCLOPS reveals human transcriptional rhythms in health and disease

(2017) Ron C. Anafi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

(2017) Mee-Sup Yoon   Nutrients

Remote reprogramming of hepatic circadian transcriptome by breast cancer

(2017) Hiroaki Hojo et al.   Oncotarget

Calorie restriction effects on circadian rhythms in gene expression are sex dependent

(2017) Artem A. Astafev et al.   Scientific Reports

Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy

(2017) Jonathan O. Lipton et al.   Cell Reports

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group

(2017) I. Puzanov et al.   Journal for ImmunoTherapy of Cancer

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

(2016) Aziz Sancar   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High Incidence of Breast Cancer in Light-Polluted Areas with Spatial Effects in Korea

(2016) Yun Jeong Kim et al.   Asian Pacific Journal of Cancer Prevention

Sleep disruption, chronotype, shift work, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins

(2016) Barbra A. Dickerman et al.   CANCER CAUSES & CONTROL

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Circadian clocks govern calorie restriction–mediated life span extension through BMAL1- and IGF-1-dependent mechanisms

(2016) Sonal A. Patel et al.   FASEB JOURNAL

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

(2016) Junjian Wang et al.   NATURE MEDICINE

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

(2016) Robert Dallmann et al.   TRENDS IN MOLECULAR MEDICINE

Per2 participates in AKT-mediated drug resistance in A549/DDP lung adenocarcinoma cells

(2016) Bo Chen et al.   Oncology Letters

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

(2016) Camila S. Matsumoto et al.   Oncotarget

Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms

(2016) Sonal A. Patel et al.   Scientific Reports

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

(2016) Xiao Hu et al.   OncoImmunology

Metabolic clock generates nutrient anticipation rhythms in mTOR signaling

(2016) Rohini V. Khapre et al.   Aging-US

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

(2016) Rohini V. Khapre et al.   Aging-US

Sleep Duration and Disruption and Prostate Cancer Risk: a 23-Year Prospective Study

(2015) S. C. Markt et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010)

(2015) C. R. Marinac et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

(2015) Gad Asher et al.   CELL

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation

(2015) Jonathan O. Lipton et al.   CELL

Circadian clocks, epigenetics, and cancer

(2015) Selma Masri et al.   CURRENT OPINION IN ONCOLOGY

Night shift work, chronotype and prostate cancer risk in the MCC-Spain case-control study

(2015) Kyriaki Papantoniou et al.   INTERNATIONAL JOURNAL OF CANCER

The Circadian Gene Clock Plays an Important Role in Cell Apoptosis and the DNA Damage Response In Vitro

(2015) Fan Wang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk

(2015) Catherine R. Marinac et al.   PLoS One

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer

(2015) Jiankun Gao et al.   Oncotarget

Circadian Clock, Cancer, and Chemotherapy

(2014) Aziz Sancar et al.   BIOCHEMISTRY

Circadian clocks and energy metabolism

(2014) Gencer Sancar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney

(2014) Sander A. Huisman et al.   INTERNATIONAL JOURNAL OF CANCER

Reciprocal interaction between the suprachiasmatic nucleus and the immune system tunes down the inflammatory response to lipopolysaccharide

(2014) Natalí N. Guerrero-Vargas et al.   JOURNAL OF NEUROIMMUNOLOGY

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Transcriptional Control of Antioxidant Defense by the Circadian Clock

(2013) Sonal A. Patel et al.   ANTIOXIDANTS & REDOX SIGNALING

A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy

(2013) X.-M. Li et al.   CANCER RESEARCH

Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma

(2013) Hiroyuki Okazaki et al.   CANCER RESEARCH

Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

(2013) Hagit Schwimmer et al.   CHRONOBIOLOGY INTERNATIONAL

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(2013) Christos Savvidis et al.   MOLECULAR MEDICINE

Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling

(2013) Ruifeng Cao et al.   NEURON

Circadian Disruption, Sleep Loss, and Prostate Cancer Risk: A Systematic Review of Epidemiologic Studies

(2012) L. G. Sigurdardottir et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer

(2012) Pasquale F. Innominato et al.   INTERNATIONAL JOURNAL OF CANCER

Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review)

(2012) GIULIA COSTANZA LEONARDI et al.   ONCOLOGY REPORTS

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

(2012) Anders Knutsson et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Shift work and cancer risk: Potential mechanistic roles of circadian disruption, light at night, and sleep deprivation

(2012) Erhard L. Haus et al.   SLEEP MEDICINE REVIEWS

Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts

(2011) J. Wu et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Disruption of the circadian clock due to theClockmutation has discrete effects on aging and carcinogenesis

(2011) Marina P. Antoch et al.   CELL CYCLE

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

Control of skin cancer by the circadian rhythm

(2011) S. Gaddameedhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Molecular Mechanism for Circadian Clock Negative Feedback

(2011) H. A. Duong et al.   SCIENCE

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

Cancer Inhibition through Circadian Reprogramming of Tumor Transcriptome with Meal Timing

(2010) X. M. Li et al.   CANCER RESEARCH

Mammalian Target of Rapamycin Signaling Modulates Photic Entrainment of the Suprachiasmatic Circadian Clock

(2010) R. Cao et al.   JOURNAL OF NEUROSCIENCE

Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells

(2010) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer

(2009) Mohamed Bouchahda et al.   CANCER

Circadian Rhythm in Rest and Activity: A Biological Correlate of Quality of Life and a Predictor of Survival in Patients with Metastatic Colorectal Cancer

(2009) P. F. Innominato et al.   CANCER RESEARCH

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

(2009) Eric E. Zhang et al.   CELL

Circadian Disruption in Experimental Cancer Processes

(2009) Elisabeth Filipski et al.   INTEGRATIVE CANCER THERAPIES

Light-at-night, circadian disruption and breast cancer: assessment of existing evidence

(2009) R. G Stevens   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study

(2008) M Kakizaki et al.   BRITISH JOURNAL OF CANCER

A Randomized Multicenter Study of Optimal Circadian Time of Vinorelbine Combined with Chronomodulated 5‐Fluorouracil in Pretreated Metastatic Breast Cancer Patients: EORTC Trial 05971

(2008) Bruno Coudert et al.   CHRONOBIOLOGY INTERNATIONAL

Light at Night Co‐distributes with Incident Breast but not Lung Cancer in the Female Population of Israel

(2008) Itai Kloog et al.   CHRONOBIOLOGY INTERNATIONAL