Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

Circadian Oscillations Persist in Low Malignancy Breast Cancer Cells

(2019) Sujeewa S. Lellupitiyage Don et al.   CELL CYCLE

Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice

(2019) Kazunari Nohara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase

(2018) Taewon Yuk et al.   Evidence-based Complementary and Alternative Medicine

Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes

(2018) Somchaiya Surichan et al.   FOOD AND CHEMICAL TOXICOLOGY

Rational cell culture optimization enhances experimental reproducibility in cancer cells

(2018) Marina Wright Muelas et al.   Scientific Reports

The day/night difference in the circadian clock's response to acute lipopolysaccharide and the rhythmic Stat3 expression in the rat suprachiasmatic nucleus

(2018) Simona Moravcová et al.   PLoS One

Computational and experimental insights into the circadian effects of SIRT1

(2018) Panagiota T. Foteinou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entrainment of Breast Cell Lines Results in Rhythmic Fluctuations of MicroRNAs

(2017) Rafael Chacolla-Huaringa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nobiletin protects against murine l -arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT

(2016) Bing Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Identification of circadian-related gene expression profiles in entrained breast cancer cell lines

(2016) Miguel A. Gutiérrez-Monreal et al.   CHRONOBIOLOGY INTERNATIONAL

Molecular Targets for Small-Molecule Modulators of Circadian Clocks

(2016) Baokun He et al.   CURRENT DRUG METABOLISM

Inhibitory Effects of Metabolites of 5-Demethylnobiletin on Human Nonsmall Cell Lung Cancer Cells

(2016) Mingyue Song et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy

(2016) Ning Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathway

(2016) CHUNLI DA et al.   ONCOLOGY REPORTS

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression

(2016) Hsin-Lin Cheng et al.   Oncotarget

Interdependence of initial cell density, drug concentration and exposure time revealed by real-time impedance spectroscopic cytotoxicity assay

(2015) C. Caviglia et al.   ANALYST

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway

(2015) JIANCHU CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide

(2015) Simona Moravcová et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function

(2015) Yongjian Xiong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

(2015) Li-Ming Lien et al.   PHYTOTHERAPY RESEARCH

Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats

(2014) Nodoka Yasuda et al.   BRAIN RESEARCH

Strengths and Limitations of Period Estimation Methods for Circadian Data

(2014) Tomasz Zielinski et al.   PLoS One

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

(2014) Céline Feillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

(2014) Pei-Ching Hsiao et al.   TUMOR BIOLOGY

An introduction to the wound healing assay using live-cell microscopy

(2014) James E. N. Jonkman et al.   Cell Adhesion & Migration

Ras-Mediated Deregulation of the Circadian Clock in Cancer

(2014) Angela Relógio et al.   PLoS Genetics

Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells

(2014) Jianchu Chen et al.   BMC Pharmacology & Toxicology

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse

(2013) Akira Nakajima et al.   BEHAVIOURAL BRAIN RESEARCH

CYP1A1 Regulates Breast Cancer Proliferation and Survival

(2013) Mariangellys Rodriguez et al.   MOLECULAR CANCER RESEARCH

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

(2013) Y. Yabuki et al.   NEUROSCIENCE

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Entrainment of breast (cancer) epithelial cells detects distinct circadian oscillation patterns for clock and hormone receptor genes

(2012) Stefano Rossetti et al.   CELL CYCLE

Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells

(2012) Somchaiya Surichan et al.   FOOD AND CHEMICAL TOXICOLOGY

Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice

(2012) Young-Sil Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

(2012) Tsukasa Tominari et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Persistent Cell-Autonomous Circadian Oscillations in Fibroblasts Revealed by Six-Week Single-Cell Imaging of PER2::LUC Bioluminescence

(2012) Tanya L. Leise et al.   PLoS One

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

(2011) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing circadian expression data by harmonic regression based on autoregressive spectral estimation

(2010) R. Yang et al.   BIOINFORMATICS

Cancer Inhibition through Circadian Reprogramming of Tumor Transcriptome with Meal Timing

(2010) X. M. Li et al.   CANCER RESEARCH

Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells

(2010) Yi-Chieh Lee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin

(2010) Li-Tao Yi et al.   PHYSIOLOGY & BEHAVIOR

Network Features of the Mammalian Circadian Clock

(2009) Julie E Baggs et al.   PLOS BIOLOGY

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 

(2008) T. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA