The emerging link between cancer, metabolism, and circadian rhythms

Circadian nutritional behaviours and cancer risk: New insights from the NutriNet-santé prospective cohort study: Disclaimers

(2018) Bernard Srour et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular Cogs: Interplay between Circadian Clock and Cell Cycle

(2018) Jonathan Gaucher et al.   TRENDS IN CELL BIOLOGY

Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle

(2018) Shogo Sato et al.   Molecular Metabolism

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

(2018) Kenneth A. Dyar et al.   CELL

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

(2018) Gabriele Sulli et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Oxidative DNA damage during night shift work

(2017) Parveen Bhatti et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency

(2016) Jennifer J. Brady et al.   CANCER CELL

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

Hypothesis: solid tumours behave as systemic metabolic dictators

(2016) Yang-Ming Lee et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways

(2016) Yue Gao et al.   JOURNAL OF PINEAL RESEARCH

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles

(2016) Rona Aviram et al.   MOLECULAR CELL

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Effect of Melatonin in Epithelial Mesenchymal Transition Markers and Invasive Properties of Breast Cancer Stem Cells of Canine and Human Cell Lines

(2016) Naiane do Nascimento Gonçalves et al.   PLoS One

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

(2016) Robert Dallmann et al.   TRENDS IN MOLECULAR MEDICINE

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

(2016) Anton Shostak et al.   Nature Communications

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

(2015) Gad Asher et al.   CELL

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Circadian clocks, epigenetics, and cancer

(2015) Selma Masri et al.   CURRENT OPINION IN ONCOLOGY

Night shift work, chronotype and prostate cancer risk in the MCC-Spain case-control study

(2015) Kyriaki Papantoniou et al.   INTERNATIONAL JOURNAL OF CANCER

Comparative Circadian Metabolomics Reveal Differential Effects of Nutritional Challenge in the Serum and Liver

(2015) Serena Abbondante et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

(2015) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

(2015) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1

(2014) Saurabh Sahar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Physiology and pharmacology of melatonin in relation to biological rhythms

(2014) Jolanta B. Zawilska et al.   Pharmacological Reports

Tumor Macroenvironment and Metabolism

(2014) Wael Al-Zhoughbi et al.   SEMINARS IN ONCOLOGY

A Novel Serum Metabolomics-Based Diagnostic Approach to Pancreatic Cancer

(2013) T. Kobayashi et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A serum nuclear magnetic resonance-based metabolomic signature of advanced metastatic human breast cancer

(2013) Elodie Jobard et al.   CANCER LETTERS

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Effects of Melatonin on Appetite and Other Symptoms in Patients With Advanced Cancer and Cachexia: A Double-Blind Placebo-Controlled Trial

(2013) Egidio Del Fabbro et al.   JOURNAL OF CLINICAL ONCOLOGY

Histone methyltransferase MLL3 contributes to genome-scale circadian transcription

(2013) Utham K. Valekunja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Low-Carbohydrate, High-Protein Diet Affects Rhythmic Expression of Gluconeogenic Regulatory and Circadian Clock Genes in Mouse Peripheral Tissues

(2012) Katsutaka Oishi et al.   CHRONOBIOLOGY INTERNATIONAL

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells

(2012) Basant Kumar Thakur et al.   INTERNATIONAL JOURNAL OF CANCER

Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

(2012) Lulu Mao et al.   MOLECULAR ENDOCRINOLOGY

Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer

(2012) Siwei Wei et al.   Molecular Oncology

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

(2012) Selma Masri et al.   NATURE REVIEWS NEUROSCIENCE

A Novel Serum Metabolomics-Based Diagnostic Approach for Colorectal Cancer

(2012) Shin Nishiumi et al.   PLoS One

Coordination of the transcriptome and metabolome by the circadian clock

(2012) K. L. Eckel-Mahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human circadian metabolome

(2012) R. Dallmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

(2012) Anders Knutsson et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Epigenetic Impact of Long-Term Shiftwork: Pilot Evidence From Circadian Genes and Whole-Genome Methylation Analysis

(2011) Yong Zhu et al.   CHRONOBIOLOGY INTERNATIONAL

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

A Molecular Mechanism for Circadian Clock Negative Feedback

(2011) H. A. Duong et al.   SCIENCE

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

(2011) Guillaume Rey et al.   PLOS BIOLOGY

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

The Core Circadian Gene Cryptochrome 2 Influences Breast Cancer Risk, Possibly by Mediating Hormone Signaling

(2010) A. E. Hoffman et al.   Cancer Prevention Research

CLOCK in Breast Tumorigenesis: Genetic, Epigenetic, and Transcriptional Profiling Analyses

(2010) A. E. Hoffman et al.   CANCER RESEARCH

Plasticity and specificity of the circadian epigenome

(2010) Selma Masri et al.   NATURE NEUROSCIENCE

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

(2010) Sayako Katada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

(2009) A. Nahimana et al.   BLOOD

Epigenetic Inactivation of the Circadian Clock Gene BMAL1 in Hematologic Malignancies

(2009) H. Taniguchi et al.   CANCER RESEARCH

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

(2009) Christopher Vollmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription

(2009) Hiroshi Hosoda et al.   Molecular Brain

Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study

(2008) M Kakizaki et al.   BRITISH JOURNAL OF CANCER

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

(2008) Theresa Alenghat et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

(2008) Maksim V. Plikus et al.   NATURE