ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Understanding the Mechanisms of Androgen Deprivation Resistance in Prostate Cancer at the Molecular Level

(2015) Theodoros Karantanos et al.   EUROPEAN UROLOGY

Targeting the MLL complex in castration-resistant prostate cancer

(2015) Rohit Malik et al.   NATURE MEDICINE

Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study

(2015) H. Ross-Adams et al.   EBioMedicine

Immune Infiltration and Prostate Cancer

(2015) Amy Strasner et al.   Frontiers in Oncology

ROR nuclear receptors: structures, related diseases and drug discovery

(2014) Yan Zhang et al.   ACTA PHARMACOLOGICA SINICA

Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

(2014) Y. Wang et al.   CANCER RESEARCH

p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

(2014) Jian Zhong et al.   CANCER RESEARCH

Aberrant Presentation of HPA-Reactive Carbohydrates Implies Selectin-Independent Metastasis Formation in Human Prostate Cancer

(2014) T. Lange et al.   CLINICAL CANCER RESEARCH

Galeterone Prevents Androgen Receptor Binding to Chromatin and Enhances Degradation of Mutant Androgen Receptor

(2014) Z. Yu et al.   CLINICAL CANCER RESEARCH

Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer

(2014) C. Liu et al.   CLINICAL CANCER RESEARCH

Nuclear receptors rock around the clock

(2014) X. Zhao et al.   EMBO REPORTS

Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

(2014) Yan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

Androgen deprivation–induced NCoA2 promotes metastatic and castration-resistant prostate cancer

(2014) Jun Qin et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects

(2014) R Ferraldeschi et al.   ONCOGENE

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model

(2014) H G Nguyen et al.   ONCOGENE

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

(2014) Olivier René et al.   ACS Medicinal Chemistry Letters

Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity

(2014) Yukimasa Takeda et al.   PLoS Genetics

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors

(2013) Yonghui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Steroid Receptor Coactivator-3 Is Required for the Development of Castration-Resistant Prostate Cancer

(2013) Jean C-Y. Tien et al.   CANCER RESEARCH

Molecular Pathways: Targeting Resistance in the Androgen Receptor for Therapeutic Benefit

(2013) E. A. Mostaghel et al.   CLINICAL CANCER RESEARCH

An androgen receptor N-terminal domain antagonist for treating prostate cancer

(2013) Jae-Kyung Myung et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of androgen receptor and  -catenin activity in prostate cancer

(2013) E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

Identification of a Selective RORγ Ligand That Suppresses TH17 Cells and Stimulates T Regulatory Cells

(2012) Laura A. Solt et al.   ACS Chemical Biology

Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator

(2012) Naresh Kumar et al.   ACS Chemical Biology

New Therapeutic Approach to Suppress Castration-Resistant Prostate Cancer Using ASC-J9 via Targeting Androgen Receptor in Selective Prostate Cells

(2012) Kuo-Pao Lai et al.   AMERICAN JOURNAL OF PATHOLOGY

The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man

(2012) Naomi L. Sharma et al.   CANCER CELL

Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

(2012) R. Hu et al.   CANCER RESEARCH

Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

(2012) Q. Zhang et al.   CANCER RESEARCH

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Histone Methyltransferase NSD2/MMSET Mediates Constitutive NF- B Signaling for Cancer Cell Proliferation, Survival, and Tumor Growth via a Feed-Forward Loop

(2012) P. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Modeling Truncated AR Expression in a Natural Androgen Responsive Environment and Identification of RHOB as a Direct Transcriptional Target

(2012) Hui-Chi Tsai et al.   PLoS One

Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma

(2011) Bettina Meissburger et al.   EMBO Molecular Medicine

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

(2010) Naresh Kumar et al.   ACS Chemical Biology

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

(2010) Jindan Yu et al.   CANCER CELL

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

(2010) Daniel E. Frigo et al.   CANCER RESEARCH

ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2

(2010) E. V. Kalashnikova et al.   CANCER RESEARCH

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression

(2010) Ankur Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

NF-κB Regulates Androgen Receptor Expression and Prostate Cancer Growth

(2009) Liying Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

LEF1 in Androgen-Independent Prostate Cancer: Regulation of Androgen Receptor Expression, Prostate Cancer Growth, and Invasion

(2009) Y. Li et al.   CANCER RESEARCH

Androgen-Induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer

(2009) J. X. Zou et al.   CANCER RESEARCH

Genomic Strategy for Targeting Therapy in Castration-Resistant Prostate Cancer

(2009) Prateek Mendiratta et al.   JOURNAL OF CLINICAL ONCOLOGY

ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactions

(2009) Dominic Schmidt et al.   METHODS

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY