Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways

Adenosine and the Cardiovascular System: The Good and the Bad

(2020) Régis Guieu et al.   Journal of Clinical Medicine

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

(2020) Wiwin Is Effendi et al.   Cells

Purinergic Signaling in the Hallmarks of Cancer

(2020) Anaí del Rocío Campos-Contreras et al.   Cells

Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer

(2020) Jennifer R. Diamond et al.   BREAST CANCER RESEARCH AND TREATMENT

Recent Advances in the Role of the Adenosinergic System in Coronary Artery Disease

(2020) Franck Paganelli et al.   CARDIOVASCULAR RESEARCH

The Crosstalk between FAK and Wnt Signaling Pathways in Cancer and Its Therapeutic Implication

(2020) Janine Wörthmüller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

(2019) Kenneth A. Jacobson et al.   Frontiers in Cellular Neuroscience

Ability of CP-532,903 to protect mouse hearts from ischemia/reperfusion injury is dependent on expression of A3 adenosine receptors in cardiomyoyctes

(2019) Tina C. Wan et al.   BIOCHEMICAL PHARMACOLOGY

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

(2019) Antonella Fiordelisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adenosine Interaction with Adenosine Receptor A2a Promotes Gastric Cancer Metastasis by Enhancing PI3K–AKT–mTOR Signaling

(2019) Linsen Shi et al.   MOLECULAR BIOLOGY OF THE CELL

Macrophages as a Source and Recipient of Wnt Signals

(2019) Elizabeth S. Malsin et al.   Frontiers in Immunology

Safety and efficacy of the partial adenosine A1 receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced ejection fraction: a phase IIb, randomized, double‐blind, placebo‐controlled trial

(2019) Adriaan A. Voors et al.   EUROPEAN JOURNAL OF HEART FAILURE

Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers

(2019) Yves Lecarpentier et al.   Frontiers in Oncology

Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors

(2018) Wen-bin Fu et al.   ACTA PHARMACOLOGICA SINICA

On the G protein-coupling selectivity of the native A 2B adenosine receptor

(2018) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

P2Y12 receptor inhibitors: an evolution in drug design to prevent arterial thrombosis

(2018) Danny Kupka et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Adenosine Receptor-Mediated Cardioprotection—Current Limitations and Future Directions

(2018) Robert D. Lasley   Frontiers in Pharmacology

Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis

(2018) Edyta Działo et al.   ACTA BIOCHIMICA POLONICA

Expressions of adenosine A2A receptors in coronary arteries and peripheral blood mononuclear cells are correlated in coronary artery disease patients

(2017) Vlad Gariboldi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Hippo pathway deficiency reverses systolic heart failure after infarction

(2017) John P. Leach et al.   NATURE

Hypoxia induces heart regeneration in adult mice

(2017) Yuji Nakada et al.   NATURE

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist

(2017) Jesung Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

(2017) Jaqueline da Silva et al.   Drug Design Development and Therapy

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

(2017) Sarawuth Phosri et al.   Frontiers in Pharmacology

Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis

(2017) Elizabeth A. Vecchio et al.   Frontiers in Pharmacology

Myofibroblasts and inflammatory cells as players of cardiac fibrosis

(2016) Hitoshi Kurose et al.   ARCHIVES OF PHARMACAL RESEARCH

The role of Wnt regulation in heart development, cardiac repair and disease: A tissue engineering perspective

(2016) Aric Pahnke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

(2016) Elizabeth A. Vecchio et al.   BIOCHEMICAL PHARMACOLOGY

Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-cateninClinical Perspective

(2016) Da Wo et al.   CIRCULATION

VCP746, a novel A1adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model

(2016) Chung H Chuo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Wnt signaling pathway in cancer

(2016) Yann Duchartre et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial

(2016) Sheraz A. Nazir et al.   EUROPEAN HEART JOURNAL

Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis

(2016) Przemyslaw Blyszczuk et al.   EUROPEAN HEART JOURNAL

Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials

(2016) Heerajnarain Bulluck et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure

(2016) Adriaan Alexander Voors et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Ocular Purine Receptors as Drug Targets in the Eye

(2016) Kenneth A. Jacobson et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Depression and coronary heart disease

(2016) Robert M. Carney et al.   Nature Reviews Cardiology

Short- and long-term (trophic) purinergic signalling

(2016) Geoffrey Burnstock   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis

(2016) Gibran Shaikh et al.   Purinergic Signalling

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Loss of Secreted Frizzled-Related Protein-1 Leads to Deterioration of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy

(2015) P. Sklepkiewicz et al.   Circulation-Heart Failure

Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure

(2015) Stephen J. Greene et al.   HEART FAILURE REVIEWS

Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration

(2015) Tuncay Yetgin et al.   JACC-Cardiovascular Interventions

Noninvasive characterization of atrioventricular conduction in patients with atrial fibrillation

(2015) Valentina D.A. Corino et al.   JOURNAL OF ELECTROCARDIOLOGY

P2Y12receptors: structure and function

(2015) M. Cattaneo   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway

(2015) Yikui Tian et al.   Oxidative Medicine and Cellular Longevity

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Cardiac cAMP: production, hydrolysis, modulation and detection

(2015) Cédric Boularan et al.   Frontiers in Pharmacology

Aldehyde dehydrogenase-2 protects against myocardial infarction-related cardiac fibrosis through modulation of the Wnt/β-catenin signaling pathway

(2015) Yingchun Zhou et al.   Therapeutics and Clinical Risk Management

Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor

(2014) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Primary results of the PROMISE trial: myocardial protection with intracoronary adenosine given before reperfusion in patients with STEMI

(2014) D. Garcia-Dorado et al.   EUROPEAN HEART JOURNAL

Adenosine Receptors: Expression, Function and Regulation

(2014) Sandeep Sheth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology

(2013) Derek J. Hausenloy et al.   CARDIOVASCULAR RESEARCH

Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model

(2013) Hao Zhang et al.   HEART RHYTHM

Cardiovascular adenosine receptors: Expression, actions and interactions

(2013) John P. Headrick et al.   PHARMACOLOGY & THERAPEUTICS

Rap1 and Rap2 Antagonistically Control Endothelial Barrier Resistance

(2013) Willem-Jan Pannekoek et al.   PLoS One

Regulation of Neutrophil Function by Adenosine

(2012) Kathryn E. Barletta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Premature myocardial infarction is associated with low serum levels of Wnt-1

(2012) Georg Goliasch et al.   ATHEROSCLEROSIS

Adenosine A2A and A3 Receptors Are Involved in the Human Endothelial Progenitor Cells Migration

(2012) Paulina Fernandez et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

An Update on Cardioprotection

(2012) Paul Z. Gerczuk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myofibroblasts in the Infarct Area: Concepts and Challenges

(2012) Evangelos P. Daskalopoulos et al.   MICROSCOPY AND MICROANALYSIS

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Association of Coffee Drinking with Total and Cause-Specific Mortality

(2012) Neal D. Freedman et al.   NEW ENGLAND JOURNAL OF MEDICINE

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction

(2011) Hilde Laeremans et al.   CIRCULATION

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction

(2011) W. Desmet et al.   EUROPEAN HEART JOURNAL

Adenosine Receptor-Mediated Cardioprotection

(2011) Victoria J. McIntosh et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Partial adenosine A1 receptor agonists for cardiovascular therapies

(2011) Barbara E. Albrecht-Küpper et al.   Purinergic Signalling

The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators

(2010) Jia-Ling Teo et al.   ADVANCED DRUG DELIVERY REVIEWS

Active Wnt signaling in response to cardiac injury

(2010) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation

(2010) John P. Headrick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development

(2010) Susanne Gessert et al.   CIRCULATION RESEARCH

A Novel Highly Selective Adenosine A1 Receptor Agonist VCP28 Reduces Ischemia Injury in a Cardiac Cell Line and Ischemia–Reperfusion Injury in Isolated Rat Hearts at Concentrations That Do Not Affect Heart Rate

(2010) Vijay B Urmaliya et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors

(2010) Oscar Ö. Braun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Secreted Frizzled Related Protein 4 Reduces Fibrosis Scar Size and Ameliorates Cardiac Function After Ischemic Injury

(2010) Kentaro Matsushima et al.   TISSUE ENGINEERING PART A

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death

(2010) G Burnstock et al.   Cell Death & Disease

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

New Pharmacological Agents for Arrhythmias

(2009) Pamela K. Mason et al.   Circulation-Arrhythmia and Electrophysiology

Effect of High-Dose Intracoronary Adenosine Administration During Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction

(2009) Marieke L. Fokkema et al.   Circulation-Cardiovascular Interventions

Rolofylline: a selective adenosine 1 receptor antagonist for the treatment of heart failure

(2009) Mara T Slawsky et al.   EXPERT OPINION ON PHARMACOTHERAPY

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Functional interaction between native G protein-coupled purinergic receptors in Xenopus follicles

(2009) R. O. Arellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

(2008) Claudia Pereira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

(2008) Gennady G. Yegutkin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

(2008) Motohiro Nishida et al.   EMBO JOURNAL

A1adenosine receptor agonists and their potential therapeutic applications

(2008) Elfatih Elzein et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Macrophage roles following myocardial infarction

(2008) Jessica M. Lambert et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

(2008) Weidong Zhu et al.   NATURE

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

(2008) Koichi Kobayashi et al.   NATURE CELL BIOLOGY

Repetitive stimulation of adenosine A1 receptors in vivo: Changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia

(2007) Viktor Roman et al.   BRAIN RESEARCH