Article
Medicine, General & Internal
Chao Yin, Zhishuai Ye, Jian Wu, Chenxing Huang, Le Pan, Huaiyu Ding, Lei Zhong, Lei Guo, Yan Zou, Xiang Wang, Ying Wang, Pan Gao, Xuejuan Jin, Xiaoxiang Yan, Yunzeng Zou, Rongchong Huang, Hui Gong
Summary: The study found that elevated levels of Wnt2 and Wnt4 in the serum of AMI patients were associated with adverse outcomes. Wnt2 and Wnt4 promote cardiac fibrosis by activating the beta-catenin/NF-kappa B signaling pathway, potentially impacting the cardiac function of AMI patients.
Article
Medicine, Research & Experimental
Tianbao Ye, Zhiwen Yan, Cheng Chen, Di Wang, Aiting Wang, Taixi Li, Boshen Yang, Xianting Ding, Chengxing Shen
Summary: This study aimed to investigate the cardioprotective role of lactoferrin (Ltf) in myocardial infarction (MI) and its underlying mechanisms. Proteomic analysis revealed that Ltf was significantly upregulated in MI hearts but decreased in circulation, and its expression was positively correlated with cardiac function. Ltf administration attenuated cardiac fibrosis and remodeling, improved cardiac function, and reduced the incidence of heart failure post-MI.
Article
Pharmacology & Pharmacy
Jing Liu, Xuehui Zheng, Chen Zhang, Chunmei Zhang, Peili Bu
Summary: The study demonstrated that ARNI alleviated myocardial fibrosis by inhibiting the Wnt/beta-catenin signaling pathway and overexpressing sFRP-1, thereby improving cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xuehui Zheng, Lingxin Liu, Jing Liu, Chen Zhang, Jie Zhang, Yan Qi, Lin Xie, Chunmei Zhang, Guoqing Yao, Peili Bu
Summary: The study shows that adverse remodeling after myocardial infarction (MI) is associated with heart failure and sudden cardiac death. Fibulin7 (FBLN7) is a critical profibrotic regulator of post-MI cardiac remodeling. FBLN7 binds to the epidermal growth factor receptor (EGFR) and induces autophosphorylation of EGFR, leading to fibroblast-to-myofibroblast transdifferentiation and myocardial fibrosis.
Article
Immunology
Li-Ping Zhu, Wei-Lan Yin, Lei Peng, Xiao-Hong Zhou, Peng Zhou, Shu-Xia Xuan, Ying Luo, Chen Chen, Bin Cheng, Jin-Duan Lin, Yan-Mei Liu, Feng-Jun Tan, Wei-Guo Yin
Summary: The study revealed a correlation between the Glu504Lys polymorphism in the ALDH2 gene and myocardial infarction (MI), with the genotype GA/AA being an independent risk factor for MI. Alcohol consumption, high myoglobin levels, and low levels of high-density lipoprotein cholesterol were also significantly associated with a higher incidence of MI.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Medicinal
Ling Chen, Yu-Ting Wu, Xuan-Ye Gu, Ling-Peng Xie, Hui-Jie Fan, Zhang-Bin Tan, Wen-Tong Zhang, Hong-Mei Chen, Jun Li, Gui-qiong Huang, Bin Liu, Ying-Chun Zhou, Xiao-Min Sun
Summary: Mag inhibits cardiac fibroblast proliferation and collagen synthesis by enhancing ALDH2 activity, suggesting its potential as a natural ALDH2 agonist.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Yong Fu, Jun Shi, Hong Qian, Chaoyi Qin, Lulu Liu, Jiayu Shen, Hao Ma, Lang Ma, Bin Liao, Yingqiang Guo
Summary: This study investigated the therapeutic effect of peritoneal matrix-loaded pirfenidone nanodroplets (NDs) on myocardial infarction (MI) fibrosis. The results showed that the nanodroplets achieved a slow drug release and inhibited cardiac fibroblasts transformation and collagen synthesis. Combining the peritoneal matrix with pirfenidone nanodroplets showed excellent therapeutic effects on fibrosis in MI rats. This study confirmed the feasibility and synergistic effectiveness of the approach and highlighted the potential application of nanomedicine in other biomedical fields.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Guanghong Chen, Honglin Xu, Tong Xu, Wenjun Ding, Guoyong Zhang, Yue Hua, Yuting Wu, Xin Han, Lingpeng Xie, Bin Liu, Yingchun Zhou
Summary: Calycosin attenuates myocardial fibrosis and cardiac dysfunction following myocardial infarction by suppressing the TGFBR1 signaling pathway.
Review
Cell Biology
Evangelos P. Daskalopoulos, W. Matthijs Blankesteijn
Summary: The involvement of WNT signaling in post-myocardial infarction wound healing has been extensively studied, and inhibiting WNT signaling may play a valuable role in promoting cardiac injury repair and preventing the development of heart failure.
Article
Biochemistry & Molecular Biology
Lize Evens, Hanne Belien, Sarah D'Haese, Sibren Haesen, Maxim Verboven, Jean-Luc Rummens, Annelies Bronckaers, Marc Hendrikx, Dorien Deluyker, Virginie Bito
Summary: Myocardial infarction results in irreversible damage to cardiomyocytes, and current therapies are unable to prevent progression to heart failure. Research has shown that cardiac atrial appendage stem cells (CASCs) could potentially achieve effective cardiac regeneration, but transplantation into an environment with elevated levels of advanced glycation end products (AGEs) may hinder their regenerative potential. Despite pyridoxamine (PM) reducing the formation of AGEs, it did not further enhance the improved cardiac phenotype obtained with CASCs transplantation after ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Jia He, Da Wo, En Ma, Qing Wang, Jinxiao Chen, Qian Gao, Qiqin Zhao, Fang Shen, Jun Peng, Weidong Zhu, Dan-ni Ren
Summary: This study investigated the role of Huoxin pill (HXP) in protecting against myocardial ischemic injury and preventing MI-induced inflammatory response by inhibiting Wnt/beta-catenin signaling activation. The results showed that HXP administration significantly reduced cardiac ischemic injury, improved cardiac function, and decreased the expression of pro-inflammatory cytokines following MI.
Article
Cardiac & Cardiovascular Systems
Ryan M. Burke, Ronald A. Dirkx, Pearl Quijada, Janet K. Lighthouse, Amy Mohan, Meghann O'Brien, Wojciech Wojciechowski, Collynn F. Woeller, Richard P. Phipps, Jeffrey D. Alexis, John M. Ashton, Eric M. Small
Summary: Salinomycin as an antifibrotic agent demonstrates potent anti-fibrotic activity in cardiac fibroblasts, prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease, and inhibits cardiac fibroblast activation by targeting p38/MAPK and Rho signaling. Moreover, salinomycin promotes cardiomyocyte survival and improves coronary vessel density, showing promise for the treatment of heart failure patients.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shengyu Cui, Zhebo Liu, Bo Tao, Suzhen Fan, Yong Pu, Xiangping Meng, Dongqing Li, Hao Xia, Lin Xu
Summary: This study found that miR-145 can alleviate cardiac fibrosis and improve cardiac function in myocardial infarction by negatively regulating SOX9 and its downstream signaling pathways.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhuo Xu, Danni Lu, Jianmei Yuan, Liying Wang, Jiajun Wang, Ziqin Lei, Si Liu, Junjie Wu, Jian Wang, Lihua Huang
Summary: This study found that storax can improve cardiac function and reduce myocardial fibrosis by inhibiting the AT1R-Ankrd1-P53 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yu Feng, Yintu Bao, Jiaxing Ding, Huili Li, Wei Liu, Xuehua Wang, Hongquan Guan, Zhijian Chen
Summary: miR-130a plays an important role in modulating cardiac fibrosis post-myocardial infarction (MI) by directly targeting TGFBR1 to regulate the TGF-beta/Smad signaling pathway and inhibit the conversion of cardiac fibroblasts to myofibroblasts.
Article
Materials Science, Ceramics
Meng Zeng, Kuixin Lin, Zhukun Zhou, Hongmei Chen, Xiaoma Tao, Yifang Ouyang, Yong Du
Summary: A series of SiC/Al composites with different contents of 3-dimensional graphene networks (3DGN) were prepared using mechanical alloying and spark plasma sintering. The effects of 3DGN on the microstructure, mechanical properties, and corrosion behaviors of SiC-3DGN/Al composites were investigated. The results showed that 3DGN substantially enhanced the synergistic strength-toughness of SiC/Al composites by improving the interface cohesion and increasing hardness, density, ductility, and corrosion resistance in NaCl solution.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Hongmei Chen, Fengyi Chen, Hui Chen, Hongsheng Liu, Ling Chen, Long Yu
Summary: This study investigated the thermal degradation and combustion behaviors of popular synthetic biodegradable polymers in the market. The results showed that these polymers exhibit different decomposition and combustion characteristics under different conditions, providing important data for managing city waste.
WASTE MANAGEMENT & RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Lingzhi Wang, Hongmei Chen, Bo Peng, Tianrui Li, Tengyu Yin
Summary: This study proposes a robust MFS method, which addresses the issues in multi-label feature selection using graph regularization and matrix factorization. The effectiveness of the algorithm is demonstrated through experiments.
APPLIED INTELLIGENCE
(2023)
Article
Computer Science, Artificial Intelligence
Zhong Yuan, Baiyang Chen, Jia Liu, Hongmei Chen, Dezhong Peng, Peilin Li
Summary: This paper proposes an anomaly detection method based on fuzzy-rough density, which takes into account both the density and fuzziness of the samples. The method defines fuzzy-rough density, calculates attribute weights, and constructs an anomaly score. Experimental results show that the proposed method achieves better performance on three types of datasets.
APPLIED SOFT COMPUTING
(2023)
Article
Biochemistry & Molecular Biology
Zhihao Sun, Keke Liu, Chi Chen, Daibo Chen, Zequn Peng, Ran Zhou, Ling Liu, Dengmei He, Wenjing Duan, Hongmei Chen, Chenbo Huang, Zheyan Ruan, Yingxin Zhang, Liyong Cao, Xiaodeng Zhan, Shihua Cheng, Lianping Sun
Summary: In this study, the role of OsLDDT1 gene in rice pollen wall formation and pollen development was identified. It regulates lipid biosynthesis to affect pollen cell wall formation. The mutant oslddt1 showed abnormal development of pollen, leading to complete abortion. These findings have important implications for hybrid rice breeding.
Article
Oncology
Jianxiong Li, Huaguo Liang, Wentao Xiao, Peng Wei, Hongmei Chen, Zexin Chen, Ruihui Yang, Huan Jiang, Yongli Zhang
Summary: Through whole-exome sequencing, it was found that CCDC170 gene is closely associated with the survival and prognosis of ovarian cancer. High expression of CCDC170 can significantly prolong the overall survival of ovarian cancer patients, and its expression in ovarian cancer cells is significantly lower than that in normal cells.
Article
Medicine, Research & Experimental
Wenyun Huang, Wensi Niu, Hongmei Chen, Wujun Jiang, Yanbing Fu, Xiuxiu Li, Minglei Li, Jun Hua, Chunxia Hu
Summary: We aimed to develop a nomogram to predict the risk of severe influenza in previously healthy children. A total of 1135 children infected with influenza in a retrospective cohort study were included. Risk factors were identified through logistic regression analysis and a nomogram was established. The nomogram showed good predictive ability in both the training and validation cohorts.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qian Gao, Zhong-Yuan Zhou, Ya-Ning He, Ming-Hui Dong, Zhao-Ning Wang, Hong-Mei Chen
Summary: This study evaluated the toxicity of BDE-47 towards RAW264.7 mouse macrophage cells and found that it caused a decrease in cell viability, an increase in apoptosis, and inhibition of phagocytosis. The mechanisms involved mitochondrial pathway-induced cell apoptosis and oxidative damage. Treatment with an antioxidant reversed the effects, while treatment with a ROS-inducer exacerbated them. These findings highlight the critical role of oxidative damage in BDE-47-induced suppression of immune function.
Article
Immunology
Man Luo, Yuanyuan Chen, Xiangyang Pan, Hongmei Chen, Lang Fan, Yi Wen
Summary: In this study, the application and effect of the probiotic EcN on the gut microbiota-metabolism-IL-22-mitochondrial damage axis in PCOS were investigated. The results showed that EcN promoted the recovery of sex hormone levels and ovarian tissue morphology, inhibited mitochondrial autophagy in PCOS mice, and improved metabolic disorders by regulating specific metabolic pathways. Clinical trials further confirmed the beneficial effects of EcN in reducing IL-22 levels and mitochondrial damage in PCOS patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Lei Ma, Chuan Luo, Tianrui Li, Hongmei Chen, Dun Liu
Summary: With the accumulation of interesting data in various application fields, incremental datasets are becoming more common. However, selecting informative attributes from dynamically changing datasets poses challenges. Therefore, an incremental processing mechanism is desired to update the attribute reducts efficiently. In this paper, a novel dynamic graph-based fuzzy rough attribute reduction approach is proposed to handle the maintenance of fuzzy rough attribute reduction in dynamic data, which outperforms existing methods in terms of speed and quality preservation.
INTERNATIONAL JOURNAL OF MACHINE LEARNING AND CYBERNETICS
(2023)
Article
Computer Science, Artificial Intelligence
Weiyi Li, Hongmei Chen, Tianrui Li, Tengyu Yin, Chuan Luo
Summary: In this paper, a robust unsupervised feature selection method, DSLRAS, is proposed, which can capture the correlation between features and the correlation between samples through latent representation learning in both feature space and data space. Adaptive graph learning is used to maintain the local geometric structure of data more accurately, and a regularization term is added to guarantee row-sparsity and achieve better results.
INTERNATIONAL JOURNAL OF MACHINE LEARNING AND CYBERNETICS
(2023)
Article
Computer Science, Artificial Intelligence
Bo Xiong, Hongmei Chen, Tianrui Li, Xiaoling Yang
Summary: Multi-view graph clustering has attracted extensive research attention due to its ability to capture consistent and complementary information between views. However, multi-view data are mostly high-dimensional and may contain redundant and irrelevant features. In addition, the original data are often contaminated by noise and outliers, affecting the reliability of the learned affinity matrix. This study proposes a robust multi-view clustering model that combines low-dimensional and low-rank latent space learning, self-representation learning, and multi-view discrepancy induction fusion. Experimental results on benchmark datasets show that the proposed model outperforms state-of-the-art comparison models in terms of robustness and clustering performance.
APPLIED INTELLIGENCE
(2023)
Article
Infectious Diseases
Hongmei Chen, Mingze Tang, Lemeng Yao, Di Zhang, Yubin Zhang, Yingren Zhao, Han Xia, Tianyan Chen, Jie Zheng
Summary: mNGS is a novel nucleic acid method that can detect unknown and difficult pathogenic microorganisms. Its application in the etiological diagnosis of fever of unknown origin (FUO) is not well studied. This study aimed to comprehensively assess the value of mNGS in diagnosing FUO and investigate its impact on diagnosis time, hospitalization days, antibiotic consumption, and cost.
BMC INFECTIOUS DISEASES
(2023)
Article
Metallurgy & Metallurgical Engineering
Si-shu Wang, Qian-hao Zang, Hong-mei Chen, Yu-hang Guo, Feng-jian Shi, Di Feng
Summary: The Mg-1Gd-0.75Er-0.5Zn-0.18Zr (at.%) alloy with LPSO phase was prepared by metal mold casting and hot extrusion. The samples showed a bimodal microstructure, and the annealed samples had different fractions of equiaxed grains. The extrusion temperature affected the percentage of fine grains and the presence of LPSO phase, which influenced the tensile properties of the Mg alloys.
JOURNAL OF IRON AND STEEL RESEARCH INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yonghua Bi, Hongmei Chen, Wenguang Zhang, Xinwei Han, Jianzhuang Ren
Summary: We describe a case where the guidewire lasso technique was used to remove an embedded esophageal self-expanding metal stent (SEMS) after a failed attempt with the removal hook. The strut of the stent fractured during the removal procedure, making it impossible to retrieve using the hook. The retained stent was successfully removed using the lasso technique with a guidewire, and the patient remained free of dysphagia after 3 months of follow-up.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
