Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

(2016) Elizabeth A. Vecchio et al.   BIOCHEMICAL PHARMACOLOGY

VCP746, a novel A1adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model

(2016) Chung H Chuo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Purinergic signaling in scarring

(2016) Davide Ferrari et al.   FASEB JOURNAL

Extracellular nucleotide regulation and signaling in cardiac fibrosis

(2016) Tatiana Novitskaya et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

(2016) Samantha D. Francis Stuart et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic Abrogation of Adenosine A3Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension

(2016) Ting Yang et al.   Journal of the American Heart Association

Adenosine A1receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1-adrenoceptor stimulationin vivo

(2015) S-L Puhl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

(2014) Veena S. Roberts et al.   KIDNEY INTERNATIONAL

Adenosine Receptor Expression in the Development of Renal Fibrosis Following Ischemic Injury

(2014) V. Roberts et al.   TRANSPLANTATION PROCEEDINGS

Cellular Mechanisms of Tissue Fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis

(2013) David Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chronic Therapy With a Partial Adenosine A1-Receptor Agonist Improves Left Ventricular Function and Remodeling in Dogs With Advanced Heart Failure

(2013) Hani N. Sabbah et al.   Circulation-Heart Failure

Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3

(2013) Miguel Perez-Aso et al.   FASEB JOURNAL

Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model

(2013) Hao Zhang et al.   HEART RHYTHM

Adenosine signaling during acute and chronic disease states

(2013) Harry Karmouty-Quintana et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cardiovascular adenosine receptors: Expression, actions and interactions

(2013) John P. Headrick et al.   PHARMACOLOGY & THERAPEUTICS

Fibroblasts in post-infarction inflammation and cardiac repair

(2012) Wei Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fibrosis and heart failure

(2012) Ana Maria Segura et al.   HEART FAILURE REVIEWS

Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release

(2012) Almut Grenz et al.   JOURNAL OF IMMUNOLOGY

Adenosine Receptor-Mediated Cardioprotection

(2011) Victoria J. McIntosh et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

A2b adenosine receptors can change their spots

(2010) Michael V Cohen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct Roles for the A2B Adenosine Receptor in Acute and Chronic Stages of Bleomycin-Induced Lung Injury

(2010) Y. Zhou et al.   JOURNAL OF IMMUNOLOGY

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K

(2009) Francisco Villarreal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts

(2009) Sara A. Epperson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stimulation of adenosine A2B receptors induces interleukin-6 secretion in cardiac fibroblasts via the PKC-δ-P38 signalling pathway

(2009) Wei Feng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac Fibroblast

(2009) Colby A. Souders et al.   CIRCULATION RESEARCH

Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient Mice Lacking the A2B Adenosine Receptor

(2009) Y. Zhou et al.   JOURNAL OF IMMUNOLOGY

Adenosine in fibrosis

(2009) Edwin S. L. Chan et al.   Modern Rheumatology

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Adenosine signaling and the regulation of chronic lung disease

(2009) Yang Zhou et al.   PHARMACOLOGY & THERAPEUTICS

Adenosine A 3 Receptor Deficiency Exerts Unanticipated Protective Effects on the Pressure-Overloaded Left Ventricle

(2008) Zhongbing Lu et al.   CIRCULATION

Ecto-5′-Nucleotidase Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction

(2008) Xin Xu et al.   HYPERTENSION

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

The Adenosine A2b Receptor: Its Role in Inflammation

(2008) J. Ham et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure

(2007) P Kalk et al.   BRITISH JOURNAL OF PHARMACOLOGY