Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease

(2020) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease

(2020) Heather Buchanan et al.   MOLECULAR NEUROBIOLOGY

Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How

(2020) Cutler T. Lewandowski et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective Effect of Spice Oleoresins on Memory and Cognitive Impairment Associated with Scopolamine-Induced Alzheimer’s Disease in Rats

(2020) Kulal Rajashri et al.   ACS Omega

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

(2019) Masaya Tachibana et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

(2019) Kai Feng et al.   Oxidative Medicine and Cellular Longevity

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Neuron-Specific Apolipoprotein E4 (1-272) Fragment Induces Tau Hyperphosphorylation and Axonopathy via Triggering Endoplasmic Reticulum Stress

(2019) Tao Liang et al.   JOURNAL OF ALZHEIMERS DISEASE

Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease

(2019) Shijia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways

(2018) Xiaoguang Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models

(2018) Chiara Lanzillotta et al.   JOURNAL OF ALZHEIMERS DISEASE

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

(2018) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway

(2018) Juan Chen et al.   Food & Function

Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease Pathogenesis

(2018) Yuen-Shan Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPARγ/Nrf2/NF-κB signaling pathway

(2018) Qiaoling Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway

(2017) Lan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Omega-3 fatty acids increase the unfolded protein response and improve amyloid-β phagocytosis by macrophages of patients with mild cognitive impairment

(2017) Henry M. Olivera-Perez et al.   FASEB JOURNAL

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

(2017) Yannis Gerakis et al.   FEBS Journal

Mouse Models of Alzheimer’s Disease

(2017) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Multifunctional Curcumin Mediate Multitherapeutic Effects

(2017) Adeeb Shehzad et al.   JOURNAL OF FOOD SCIENCE

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular signal networks and regulating mechanisms of the unfolded protein response

(2017) Jing Gong et al.   Journal of Zhejiang University-SCIENCE B

Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease

(2017) Veena Theendakara et al.   MOLECULAR NEUROBIOLOGY

Synaptic Dysfunction in Alzheimer’s Disease: Aβ, Tau, and Epigenetic Alterations

(2017) Ke Li et al.   MOLECULAR NEUROBIOLOGY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer’s Disease

(2017) Weigang Cui et al.   NEUROCHEMICAL RESEARCH

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Mechanisms of tau and Aβ-induced excitotoxicity

(2016) Susanne P. Pallo et al.   BRAIN RESEARCH

Neuroinflammation pathways: a general review

(2016) Tara Shabab et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

DNA methylation and cerebellar development, the regulation of Notch and Shh pathway

(2016) M. Yan et al.   ITALIAN JOURNAL OF ZOOLOGY

Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells

(2015) Kun-mu Zheng et al.   ACTA PHARMACOLOGICA SINICA

Endoplasmic Reticulum Stress Aggravates Viral Myocarditis by Raising Inflammation Through the IRE1-Associated NF-κB Pathway

(2015) Xi Zha et al.   CANADIAN JOURNAL OF CARDIOLOGY

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation

(2013) Bhavana Chhunchha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

(2012) James G. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation

(2012) Lance A. Johnson et al.   JOURNAL OF LIPID RESEARCH

Neuronal Apoptosis in the Developing Cerebellum

(2010) X.-S. Cheng et al.   ANATOMIA HISTOLOGIA EMBRYOLOGIA

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY