Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer’s Disease

Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B-mediated tau phosphorylation in rats

(2017) Lei Tan et al.   NEUROPHARMACOLOGY

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

(2016) Shira Knafo et al.   NATURE NEUROSCIENCE

Neuregulin-1 attenuates cognitive function impairments in a transgenic mouse model of Alzheimer’s disease

(2016) J Ryu et al.   Cell Death & Disease

Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling

(2015) Yuta Yoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells

(2015) Xiaojuan Quan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?

(2015) Ana I. Placido et al.   CNS & Neurological Disorders-Drug Targets

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Di-O-demethylcurcumin protects SK-N-SH cells against mitochondrial and endoplasmic reticulum-mediated apoptotic cell death induced by Aβ25-35

(2015) Decha Pinkaew et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia

(2015) A.H. Martins et al.   NEUROSCIENCE

Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats

(2015) Yujie Chen et al.   NEUROSCIENCE LETTERS

Suppression effects of O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress in SK-N-SH cells

(2015) Adchara Janyou et al.   NEUROTOXICOLOGY

Melatonin Modulates Endoplasmic Reticulum Stress and Akt/GSK3-Beta Signaling Pathway in a Rat Model of Renal Warm Ischemia Reperfusion

(2015) Kaouther Hadj Ayed Tka et al.   Analytical Cellular Pathology

Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells

(2014) Bingqian Liu et al.   CELL STRESS & CHAPERONES

Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease

(2014) Tae-In Kam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chronic restraint stress promotes learning and memory impairment due to enhanced neuronal endoplasmic reticulum stress in the frontal cortex and hippocampus in male mice

(2014) RONG-RONG HUANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusionvia activation of PI3K/Akt/ERK1/2 pathway

(2014) Zhouguang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endoplasmic Reticulum Stress: Relevance and Therapeutics in Central Nervous System Diseases

(2014) Hong-Yu Zhang et al.   MOLECULAR NEUROBIOLOGY

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

(2014) Ana I. Plácido et al.   MOLECULAR NEUROBIOLOGY

Puerarin Protects Against β-Amyloid-Induced Microglia Apoptosis Via a PI3K-Dependent Signaling Pathway

(2014) Cui Wang et al.   NEUROCHEMICAL RESEARCH

Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer’s disease

(2014) Han-Chang Huang et al.   NEUROLOGICAL RESEARCH

Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons

(2014) Nirut Suwanna et al.   NEUROSCIENCE LETTERS

Neuroprotective and Anti-Inflammatory Roles of the Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy

(2014) Valentina Grande et al.   PLoS One

Overexpression of PTEN suppresses lipopolysaccharide-induced lung fibroblast proliferation, differentiation and collagen secretion through inhibition of the PI3-K-Akt-GSK3beta pathway

(2014) Zhengyu He et al.   Cell and Bioscience

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

(2013) W-T Chen et al.   ONCOGENE

Inhibition of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Decreases Rat Cortical Neuron Injury and Blood-Brain Barrier Permeability, and Improves Neurological Functional Recovery in Traumatic Brain Injury Model

(2013) Jun Ding et al.   PLoS One

Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury

(2013) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

(2012) Rui O. Costa et al.   AGING CELL

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production

(2012) Durvanei Augusto Maria et al.   INVESTIGATIONAL NEW DRUGS

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

(2012) L. Mao et al.   NEUROSCIENCE

Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury

(2011) Caterina Dal Ponte et al.   LIVER TRANSPLANTATION

Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress

(2011) Xiu-Yu Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

(2009) Bingqian Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Retinal ganglion cell death induced by endoplasmic reticulum stress in a chronic glaucoma model

(2009) Sang Hee Doh et al.   BRAIN RESEARCH