NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

p47phox-Nox2-dependent ROS Signaling Inhibits Early Bone Development in Mice but Protects against Skeletal Aging

(2015) Jin-Ran Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tipping the metabolic scales towards increased longevity in mammals

(2015) Celine E. Riera et al.   NATURE CELL BIOLOGY

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

(2014) Collin Y. Ewald et al.   NATURE

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Unraveling the Truth About Antioxidants: ROS and disease: finding the right balance

(2014) Hiroyuki Kawagishi et al.   NATURE MEDICINE

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

(2014) G. MacDonald et al.   Science Signaling

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans

(2014) Catalina Romero-Aristizabal et al.   Nature Communications

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling

(2014) Andrea Haag et al.   PLoS Genetics

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

(2013) Sebastian Schmeisser et al.   AGING CELL

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

NADPH Oxidase Complex-Derived Reactive Oxygen Species, the Actin Cytoskeleton, and Rho GTPases in Cell Migration

(2013) Alanna Stanley et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

A cytoprotective perspective on longevity regulation

(2013) David E. Shore et al.   TRENDS IN CELL BIOLOGY

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

(2013) Kira M. Glover-Cutter et al.   PLoS Genetics

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Identification and Functional Studies of a New Nrf2 Partner IQGAP1: A Critical Role in the Stability and Transactivation of Nrf2

(2012) Jung-Hwan Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

(2012) Thu H. Truong et al.   BIOCHEMISTRY

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury

(2012) S. Nlandu Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

MEMO1, a new IRS1-interacting protein, induces epithelial–mesenchymal transition in mammary epithelial cells

(2012) A V Sorokin et al.   ONCOGENE

ROS in AgingCaenorhabditis elegans: Damage or Signaling?

(2012) Patricia Back et al.   Oxidative Medicine and Cellular Longevity

MHO1, an Evolutionarily Conserved Gene, Is Synthetic Lethal with PLC1; Mho1p Has a Role in Invasive Growth

(2012) Ivan D. Schlatter et al.   PLoS One

Redox regulation of cell migration and adhesion

(2012) Thomas Ryan Hurd et al.   TRENDS IN CELL BIOLOGY

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

(2012) Hiroki Moribe et al.   PLoS Genetics

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo

(2011) Alison C. Brewer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

(2011) Patricia Back et al.   FREE RADICAL BIOLOGY AND MEDICINE

The RHO-1 RhoGTPase Modulates Fertility and Multiple Behaviors in Adult C. elegans

(2011) Rachel McMullan et al.   PLoS One

Extension of Lifespan in C. elegans by Naphthoquinones That Act through Stress Hormesis Mechanisms

(2011) Piper R. Hunt et al.   PLoS One

Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells

(2011) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans

(2011) Ransome van der Hoeven et al.   PLoS Pathogens

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans

(2010) W. Niu et al.   GENOME RESEARCH

The Longevity Effect of Tannic Acid in Caenorhabditis elegans: Disposable Soma Meets Hormesis

(2010) Nadine Saul et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice

(2010) Brahm H. Segal et al.   PLoS One

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Ce-Duox1/BLI-3 Generates Reactive Oxygen Species as a Protective Innate Immune Mechanism in Caenorhabditis elegans

(2009) V. Chavez et al.   INFECTION AND IMMUNITY

Memo is a cofilin-interacting protein that influences PLC 1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration

(2009) M. Meira et al.   JOURNAL OF CELL SCIENCE

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans

(2008) David Hoogewijs et al.   BMC MOLECULAR BIOLOGY

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memo–RhoA–mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells

(2008) Kossay Zaoui et al.   JOURNAL OF CELL BIOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology