Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

(2018) John L Robinson et al.   BRAIN

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

(2018) Caixia Li et al.   CELL BIOLOGY INTERNATIONAL

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

(2018) Iris Broce et al.   PLOS MEDICINE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?

(2018) Rita Guerreiro et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

(2018) Faten A. Sayed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial activation occurs late during preclinical Alzheimer's disease

(2018) Wolfgang J. Streit et al.   GLIA

TREM2 triggers microglial density and age‐related neuronal loss

(2018) Bettina Linnartz‐Gerlach et al.   GLIA

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

(2018) Honghua Zheng et al.   Frontiers in Aging Neuroscience

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

(2017) Lindsay M. De Biase et al.   NEURON

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

(2016) Elisabeth Sanchez-Mejias et al.   ACTA NEUROPATHOLOGICA

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

(2016) Thomas J. Montine et al.   Alzheimers & Dementia

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease

(2016) Jasmin Tischer et al.   GLIA

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

(2014) Isabelle Le Ber et al.   NEUROBIOLOGY OF AGING

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

(2013) Jon B. Toledo et al.   Alzheimers & Dementia

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Building an integrated neurodegenerative disease database at an academic health center

(2011) Sharon X. Xie et al.   Alzheimers & Dementia

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA