Podocyte Autophagy in Homeostasis and Disease

The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease

(2020) Soie Kwon et al.   DIABETES CARE

The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy

(2020) Yilin Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer

(2020) Rui Peng et al.   Gastric Cancer

Autophagy in kidney homeostasis and disease

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Lycopene attenuates high glucose‑mediated apoptosis in MPC5 podocytes by promoting autophagy via the PI3K/AKT signaling pathway

(2020) Qingfen Wang et al.   Experimental and Therapeutic Medicine

TGF-β1 and TNF-α synergistically induce epithelial to mesenchymal transition of breast cancer cells by enhancing TAK1 activation

(2019) Sheng-Jun Liao et al.   Journal of Cell Communication and Signaling

Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair

(2019) Guillaume Canaud et al.   Science Translational Medicine

Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease

(2019) Wei Jing Liu et al.   Cell Death & Disease

Podocytes maintain high basal levels of autophagy independent of mtor signaling

(2019) Tillmann Bork et al.   Autophagy

Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions

(2019) Chigure Suzuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in hepatic adaptation to stress

(2019) Younis Hazari et al.   JOURNAL OF HEPATOLOGY

Autophagy and innate immunity: Insights from invertebrate model organisms

(2018) Cheng-Ju Kuo et al.   Autophagy

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

(2018) Ricardo J. Antonia et al.   Science Signaling

Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy

(2018) Wei Liu et al.   Cell Death & Disease

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

(2018) Ricardo J. Antonia et al.   Science Signaling

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis

(2018) Yuan-yuan Qi et al.   ANNALS OF THE RHEUMATIC DISEASES

TAK1 mediates convergence of cellular signals for death and survival

(2018) Sabreena Aashaq et al.   APOPTOSIS

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A switch from canonical to noncanonical autophagy shapes B cell responses

(2017) Nuria Martinez-Martin et al.   SCIENCE

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators

(2016) Lori L. O'Brien et al.   DEVELOPMENT

Lipopolysaccharide-induced podocyte injury is mediated by suppression of autophagy

(2016) XIAOFAN TAN et al.   Molecular Medicine Reports

Podocyte–actin dynamics in health and disease

(2016) Luca Perico et al.   Nature Reviews Nephrology

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation

(2015) Chi G Weindel et al.   Autophagy

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism

(2015) David J. Kast et al.   CURRENT BIOLOGY

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Actin nucleation by WH2 domains at the autophagosome

(2015) Amanda S. Coutts et al.   Nature Communications

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Podocyte autophagic activity plays a protective role in renal injury and delays the progression of podocytopathies

(2014) Caihong Zeng et al.   JOURNAL OF PATHOLOGY

Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS

(2014) T. Kawakami et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Na+/H+ exchanger-1 reduces podocyte injury caused by endoplasmic reticulum stress via autophagy activation

(2014) Zhe Feng et al.   LABORATORY INVESTIGATION

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice

(2014) Tangli Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

(2013) Nan Chen et al.   Autophagy

The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes

(2013) Yu-Lin Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Up-to-date membrane biogenesis in the autophagosome formation

(2013) Maho Hamasaki et al.   CURRENT OPINION IN CELL BIOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway

(2012) Mireia Niso-Santano et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy can repair endoplasmic reticulum stress damage of the passive Heymann nephritis model as revealed by proteomics analysis

(2012) Liyuan Wang et al.   Journal of Proteomics

Spatio-temporal association between mTOR and autophagy during cellular senescence

(2011) Andrew R.J. Young et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Inhibition of autophagy by TAB2 and TAB3

(2011) Alfredo Criollo et al.   EMBO JOURNAL

Prorenin Receptor Is Essential for Podocyte Autophagy and Survival

(2011) F. Riediger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Heat shock protein 90–mediated inactivation of nuclear factor-κB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells

(2011) Qian Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The podocyte cytoskeleton—key to a functioning glomerulus in health and disease

(2011) Gavin I. Welsh et al.   Nature Reviews Nephrology

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

p53-cofactor JMY is a multifunctional actin nucleation factor

(2009) J. Bradley Zuchero et al.   NATURE CELL BIOLOGY

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL