Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

(2015) Jenny Wegert et al.   CANCER CELL

Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation

(2015) Jinshu Xu et al.   DEVELOPMENTAL DYNAMICS

Evaluation of CITED1, SIX1, and CD56 Protein Expression for Identification of Blastemal Elements in Wilms Tumor

(2014) Daniel Sehic et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Integrin Alpha 8 Recessive Mutations Are Responsible for Bilateral Renal Agenesis in Humans

(2014) Camille Humbert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis

(2014) J. Xu et al.   DEVELOPMENT

Global Quantification of Tissue Dynamics in the Developing Mouse Kidney

(2014) Kieran M. Short et al.   DEVELOPMENTAL CELL

Sall1 Maintains Nephron Progenitors and Nascent Nephrons by Acting as Both an Activator and a Repressor

(2014) S. Kanda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Principles of regulatory information conservation between mouse and human

(2014) Yong Cheng et al.   NATURE

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors

(2014) Fariba Jian Motamedi et al.   Nature Communications

Direct Transcriptional Reprogramming of Adult Cells to Embryonic Nephron Progenitors

(2013) C. E. Hendry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods

(2012) Shigeru Sato et al.   DEVELOPMENTAL BIOLOGY

FGF9 and FGF20 Maintain the Stemness of Nephron Progenitors in Mice and Man

(2012) Hila Barak et al.   DEVELOPMENTAL CELL

Six2 and Wnt Regulate Self-Renewal and Commitment of Nephron Progenitors through Shared Gene Regulatory Networks

(2012) Joo-Seop Park et al.   DEVELOPMENTAL CELL

The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration

(2012) Upeka Senanayake et al.   HUMAN PATHOLOGY

SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor

(2012) Andrew J. Murphy et al.   JOURNAL OF PEDIATRIC SURGERY

Discovery, optimization and validation of an optimal DNA-binding sequence for the Six1 homeodomain transcription factor

(2012) Yubing Liu et al.   NUCLEIC ACIDS RESEARCH

A Comprehensive View of Nuclear Receptor Cancer Cistromes

(2011) Q. Tang et al.   CANCER RESEARCH

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

(2011) Courtney M. Karner et al.   DEVELOPMENT

Nephron formation adopts a novel spatial topology at cessation of nephrogenesis

(2011) Bree A. Rumballe et al.   DEVELOPMENTAL BIOLOGY

SIX1 protein expression selectively identifies blastemal elements in Wilms tumor

(2011) Daniel Sehic et al.   PEDIATRIC BLOOD & CANCER

Human nephron number: implications for health and disease

(2011) John F. Bertram et al.   PEDIATRIC NEPHROLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Transposable elements have rewired the core regulatory network of human embryonic stem cells

(2010) Galih Kunarso et al.   NATURE GENETICS

Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding

(2010) D. Schmidt et al.   SCIENCE

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population

(2009) Joshua W. Mugford et al.   DEVELOPMENTAL BIOLOGY

The UCSC Genome Browser database: update 2010

(2009) B. Rhead et al.   NUCLEIC ACIDS RESEARCH

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development

(2008) Akio Kobayashi et al.   Cell Stem Cell

The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease

(2008) J. P. Kumar   CELLULAR AND MOLECULAR LIFE SCIENCES

Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo

(2008) Joshua W. Mugford et al.   DEVELOPMENTAL BIOLOGY

Bone morphogenetic protein signaling in the developing kidney: present and future

(2008) Jason E. Cain et al.   DIFFERENTIATION

SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development

(2008) S. Weber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data

(2008) Anton Valouev et al.   NATURE METHODS

Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia

(2007) Scott Boyle et al.   DEVELOPMENTAL BIOLOGY