Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers

Subcellular Performance of Nanoparticles in Cancer Therapy

(2020) Chen-Guang Liu et al.   International Journal of Nanomedicine

Caveolin and lipid domains–close companions in managing cellular pathways

(2020) Jody V. Vykoukal et al.   CANCER AND METASTASIS REVIEWS

Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

(2020) Nicha Puangmalai et al.   Cell Death & Disease

Macropinocytosis: Insights from immunology and cancer

(2020) Jennifer L. Stow et al.   CURRENT OPINION IN CELL BIOLOGY

Caveolae: Formation, dynamics, and function

(2020) Robert G. Parton et al.   CURRENT OPINION IN CELL BIOLOGY

pH gradient reversal fuels cancer progression

(2020) Tianyu Zheng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Self-assembled nanostructures from amphiphilic block copolymers prepared via ring-opening metathesis polymerization (ROMP)

(2020) Spyridon Varlas et al.   PROGRESS IN POLYMER SCIENCE

Low‐crystallinity to highly amorphous copolyesters with high glass transition temperatures based on rigid carbohydrate‐derived building blocks

(2020) Jingying Chen et al.   POLYMER INTERNATIONAL

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

(2020) Emanuele Papini et al.   Frontiers in Immunology

Caveolae as Potential Hijackable Gates in Cell Communication

(2020) Maria Dudãu et al.   Frontiers in Cell and Developmental Biology

An amphiphilic aggregate-induced emission polyurethane probe for in situ actin observation in living cells

(2020) Yuqing Niu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: A computational study

(2019) Reid C. Van Lehn et al.   PLoS One

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

(2019) Nathan D. Donahue et al.   ADVANCED DRUG DELIVERY REVIEWS

Doxorubicin derivative loaded acetal-PEG-PCCL micelles for overcoming multidrug resistance in MCF-7/ADR cells

(2019) Xin-Cheng Zhong et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells

(2019) Lipeng Qiu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effect of Cell Age on Uptake and Toxicity of Nanoparticles: The Overlooked Factor at the Nanobio Interface

(2019) Parisa Foroozandeh et al.   ACS Applied Materials & Interfaces

In vitro investigation of hyaluronan-based polymeric micelles for drug delivery into the skin: The internalization pathway

(2019) Jana Starigazdová et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Cell Sex on Uptake of Nanoparticles: The Overlooked Factor at the Nanobio Interface

(2018) Vahid Serpooshan et al.   ACS Nano

Walking the line: The fate of nanomaterials at biological barriers

(2018) Huan Meng et al.   BIOMATERIALS

Promoting Inter-/Intra- Cellular Process of Nanomedicine through its Physicochemical Properties Optimization

(2018) Di Chen et al.   CURRENT DRUG METABOLISM

Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes

(2018) Xiaoyou Qu et al.   DRUG DELIVERY

Cell shape affects nanoparticle uptake and toxicity: An overlooked factor at the nanobio interfaces

(2018) Fakhrossadat Farvadi et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mannose receptor (MR) and Toll-like receptor 2 (TLR2) influence phagosome maturation during Leishmania infection

(2018) R. E. Polando et al.   PARASITE IMMUNOLOGY

Entry of nanoparticles into cells: the importance of nanoparticle properties

(2018) Jiacheng Zhao et al.   Polymer Chemistry

Interaction of PCL based self-assembled nano-polymeric micelles with model lipid bilayers using coarse-grained molecular dynamics simulations

(2018) Abhinav S. Raman et al.   CHEMICAL PHYSICS LETTERS

Nano based drug delivery systems: recent developments and future prospects

(2018) Jayanta Kumar Patra et al.   JOURNAL OF NANOBIOTECHNOLOGY

Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

(2018) Nemany Hanafy et al.   Cancers

Membrane Wrapping Efficiency of Elastic Nanoparticles during Endocytosis: Size and Shape Matter

(2018) Zhiqiang Shen et al.   ACS Nano

Secondary Self-Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells

(2018) Johannes C. Brendel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-assembly of Amphiphilic Alternating Copolymers

(2018) Qingsong Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

(2018) Houliang Tang et al.   MOLECULES

Designed Polymer Micelle for Clearing Amyloid Protein Aggregates via Up-Regulated Autophagy

(2018) Koushik Debnath et al.   ACS Biomaterials-Science & Engineering

In vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells

(2017) Xiao Hu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Particle morphology: an important factor affecting drug delivery by nanocarriers into solid tumors

(2017) Zhen Wang et al.   Expert Opinion on Drug Delivery

Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia

(2017) Daniel Gündel et al.   International Journal of Nanomedicine

Polymeric micelles: Basic research to clinical practice

(2017) Anand S. Deshmukh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanodrug delivery systems for targeting the endogenous tumor microenvironment and simultaneously overcoming multidrug resistance properties

(2017) Rui Li et al.   JOURNAL OF CONTROLLED RELEASE

Kinetics of receptor-mediated endocytosis of elastic nanoparticles

(2017) Xin Yi et al.   Nanoscale

Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells

(2017) Kem A. Sochacki et al.   NATURE CELL BIOLOGY

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

Receptor-Mediated Endocytosis of Two-Dimensional Nanomaterials Undergoes Flat Vesiculation and Occurs by Revolution and Self-Rotation

(2016) Jian Mao et al.   ACS Nano

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles

(2016) Malou Henriksen-Lacey et al.   BIOCONJUGATE CHEMISTRY

The life cycle of phagosomes: formation, maturation, and resolution

(2016) Roni Levin et al.   IMMUNOLOGICAL REVIEWS

Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state

(2016) Alexandra Arranja et al.   JOURNAL OF CONTROLLED RELEASE

Self-Assembly and Critical Aggregation Concentration Measurements of ABA Triblock Copolymers with Varying B Block Types: Model Development, Prediction, and Validation

(2016) Fikret Aydin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Distinct CPT-induced deaths in lung cancer cells caused by clathrin-mediated internalization of CP micelles

(2016) Yu-Sheng Liu et al.   Nanoscale

Shape-dependent internalization kinetics of nanoparticles by membranes

(2016) Liping Chen et al.   Soft Matter

In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines

(2016) Martin Roursgaard et al.   TOXICOLOGY IN VITRO

Caveolin-1 Function in Liver Physiology and Disease

(2016) Manuel A. Fernandez-Rojo et al.   TRENDS IN MOLECULAR MEDICINE

Different oligoarginine modifications alter endocytic pathways and subcellular trafficking of polymeric nanoparticles

(2016) Junli Zhou et al.   Biomaterials Science

Macropinocytosis Exploitation by Cancers and Cancer Therapeutics

(2016) Kevin D. Ha et al.   Frontiers in Physiology

Critical Particle Sizes for the Engulfment of Nanoparticles by Membranes and Vesicles with Bilayer Asymmetry

(2015) Jaime Agudo-Canalejo et al.   ACS Nano

A Bio-Inspired Rod-Shaped Nanoplatform for Strongly Infecting Tumor Cells and Enhancing the Delivery Efficiency of Anticancer Drugs

(2015) Dan Li et al.   ADVANCED FUNCTIONAL MATERIALS

Clathrin to Lipid Raft-Endocytosis via Controlled Surface Chemistry and Efficient Perinuclear Targeting of Nanoparticle

(2015) Atanu Chakraborty et al.   Journal of Physical Chemistry Letters

Bacillus-Shape Design of Polymer Based Drug Delivery Systems with Janus-Faced Function for Synergistic Targeted Drug Delivery and More Effective Cancer Therapy

(2015) Fei Cui et al.   MOLECULAR PHARMACEUTICS

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

In vivo toxicity of cationic micelles and liposomes

(2015) Kristina Bram Knudsen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Pathway for insertion of amphiphilic nanoparticles into defect-free lipid bilayers from atomistic molecular dynamics simulations

(2015) Reid C. Van Lehn et al.   Soft Matter

Cooperative Transmembrane Penetration of Nanoparticles

(2015) Haizhen Zhang et al.   Scientific Reports

Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells

(2015) Zhenzhen Liu et al.   Frontiers in Physiology

Endocytic Mechanisms of Graphene Oxide Nanosheets in Osteoblasts, Hepatocytes and Macrophages

(2014) Javier Linares et al.   ACS Applied Materials & Interfaces

Endocytosis of PEGylated nanoparticles accompanied by structural and free energy changes of the grafted polyethylene glycol

(2014) Ying Li et al.   BIOMATERIALS

Cellular internalization of doxorubicin loaded star-shaped micelles with hydrophilic zwitterionic sulfobetaine segments

(2014) Jun Cao et al.   BIOMATERIALS

Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles

(2014) Zhou Zhou et al.   BIOMATERIALS

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: An additional barrier to non viral gene delivery

(2014) Katrien Remaut et al.   JOURNAL OF CONTROLLED RELEASE

Insight into nanoparticle cellular uptake and intracellular targeting

(2014) Basit Yameen et al.   JOURNAL OF CONTROLLED RELEASE

PEG-Stabilized Bilayer Nanodisks As Carriers for Doxorubicin Delivery

(2014) Wenping Zhang et al.   MOLECULAR PHARMACEUTICS

A multilayered cell culture model for transport study in solid tumors: Evaluation of tissue penetration of polyethyleneimine based cationic micelles

(2014) Seiji Miura et al.   Nano Today

Membrane Partitioning of Anionic, Ligand-Coated Nanoparticles Is Accompanied by Ligand Snorkeling, Local Disordering, and Cholesterol Depletion

(2014) Paraskevi Gkeka et al.   PLoS Computational Biology

Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles

(2014) Cindy Gunawan et al.   Journal of Materials Chemistry B

Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms

(2013) Ling-Gang Wu et al.   Annual Review of Physiology

Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

(2013) Xinyi Jiang et al.   BIOMATERIALS

Intracellular trafficking and cellular uptake mechanism of mPEG-PLGA-PLL and mPEG-PLGA-PLL-Gal nanoparticles for targeted delivery to hepatomas

(2013) Peifeng Liu et al.   BIOMATERIALS

Nano-sized and micro-sized polystyrene particles affect phagocyte function

(2013) B. Prietl et al.   CELL BIOLOGY AND TOXICOLOGY

Facile access to cytocompatible multicompartment micelles with adjustable Janus-cores from A-block-B-graft-C terpolymers prepared by combination of ROP and ATRP

(2013) Weiwei Wang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Amphiphilic glycopolymer nanoparticles as vehicles for nasal delivery of peptides and proteins

(2013) Chao Zheng et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Size-dependent internalisation of folate-decorated nanoparticles via the pathways of clathrin and caveolae-mediated endocytosis in ARPE-19 cells

(2013) Wai-Leung Langston Suen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking, and Drug Delivery

(2013) Xianglong Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

(2013) Zhao Zhang et al.   MACROMOLECULAR BIOSCIENCE

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

(2013) Charlotte M Smith et al.   Molecular Cancer

FRET Imaging Reveals Different Cellular Entry Routes of Self-Assembled and Disulfide Bonded Polymeric Micelles

(2013) Seung-Young Lee et al.   MOLECULAR PHARMACEUTICS

Role of Nanoparticle Geometry in Endocytosis: Laying Down to Stand Up

(2013) Changjin Huang et al.   NANO LETTERS

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

(2013) Reid C. Van Lehn et al.   NANO LETTERS

PEGylation of cationic, shell-crosslinked-knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung

(2013) Aida Ibricevic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response

(2013) Hisao Haniu et al.   TOXICOLOGY IN VITRO

Controlling Cellular Uptake of Nanoparticles with pH-Sensitive Polymers

(2013) Hong-ming Ding et al.   Scientific Reports

The endocytosis and intracellular fate of nanomedicines: Implication for rational design

(2013) Longfa Kou et al.   Asian Journal of Pharmaceutical Sciences

Molecular modeling of the relationship between nanoparticle shape anisotropy and endocytosis kinetics

(2012) Ye Li et al.   BIOMATERIALS

Penetratin-functionalized PEG–PLA nanoparticles for brain drug delivery

(2012) Huimin Xia et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics

(2012) Sourav Bhattacharjee et al.   Particle and Fibre Toxicology

Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

(2012) Xiaopin Duan et al.   Small

Effect of shell-crosslinking of micelles on endocytosis and exocytosis: acceleration of exocytosis by crosslinking

(2012) Yoseop Kim et al.   Biomaterials Science

Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma

(2011) Hongliang Xin et al.   BIOMATERIALS

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

(2011) Kai Xiao et al.   BIOMATERIALS

The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM

(2011) Sharon E. Miller et al.   CELL

Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems

(2011) Priya Prakash Karmali et al.   Expert Opinion on Drug Delivery

Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

(2011) Robert Vácha et al.   NANO LETTERS

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles

(2011) Sourav Bhattacharjee et al.   Nanotoxicology

More Effective Nanomedicines through Particle Design

(2011) Jin Wang et al.   Small

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

pH-dependent self-assembly of amphiphilic poly(l-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers

(2010) Yanan Yang et al.   POLYMER

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents

(2009) Gaurav Sahay et al.   BIOMATERIALS

Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles

(2009) Hae Yun Nam et al.   JOURNAL OF CONTROLLED RELEASE

Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes

(2008) Eik Leupold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Different Internalization Pathways of Polymeric Micelles and Unimers and Their Effects on Vesicular Transport

(2008) Gaurav Sahay et al.   BIOCONJUGATE CHEMISTRY

Surface Charge of Nanoparticles Determines Their Endocytic and Transcytotic Pathway in Polarized MDCK Cells

(2008) Oshrat Harush-Frenkel et al.   BIOMACROMOLECULES

Pemphigus Vulgaris IgG-induced Desmoglein-3 Endocytosis and Desmosomal Disassembly Are Mediated by a Clathrin- and Dynamin-independent Mechanism

(2008) Emmanuella Delva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles

(2008) Shilpa Sant et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

(2008) Ayush Verma et al.   NATURE MATERIALS

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA