Article
Chemistry, Multidisciplinary
Ni Dong, Zhenyun Liu, Haisheng He, Yi Lu, Jianping Qi, Wei Wu
Summary: In this study, different shapes of red blood cell membrane-coated mesoporous silica nanoparticles were synthesized to verify the concept of multivalent interactions. The experiments demonstrated strengthened binding and internalization of disk-shaped particles with cells, further confirming the significance of multivalent interactions in enhancing active targeting efficiency.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Applied
Jaya R. Lakkakula, Pratik Gujarathi, Prachi Pansare, Swastika Tripathi
Summary: Combining alginate with other materials as a drug delivery system can effectively enhance the targeted therapeutic effects of doxorubicin on cancer, showing great potential for widespread applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Ning Wang, Jingyi Li, Jie Wang, Di Nie, Xiaohe Jiang, Yan Zhuo, Miaorong Yu
Summary: The shape of nanoparticles plays a crucial role in their transport through biological barriers. In this study, artificial erythrocyte-like nanoparticles were developed, mimicking the shape and drug release pattern of natural erythrocytes. These nanoparticles displayed on-demand drug release and improved tumor permeability, leading to enhanced chemotherapy efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Wei Liu, Xiaoge Wang, Xiangze Fan, Danyang Zhou, Weiping Hu, Xiuhua Liu, Jinhua Zhu
Summary: A Dioscorea opposita Thunb polysaccharide (DOP)-modified ZIF8 material was developed as a smart glucose-responsive carrier for controlled drug release. The surface of ZIF8 nanoparticles was modified with 3-aminophenylboronic acid (APBA) functionalized carboxylated long-chain polymer poly(ethylene glycol) (PEG) segments through a hydrogen bond, and then chemically cross-linked with DOP through a borate ester bond. The released trans-N-p-coumaroyltyramine (NCT) and DOP showed synergistic effects in improving insulin resistance and promoting glucose consumption in insulin-resistant HepG2 cells.
Article
Agriculture, Multidisciplinary
Xin Lu, Qing Han, Jiachen Chen, Tingyu Wu, Yirui Cheng, Fan Li, Weiliang Xia
Summary: Extracellular vesicles (EVs) released from cells have shown robust efficacy in drug delivery compared with traditional synthetic carriers. However, the clinical application of EVs as drug carriers is limited due to high production cost and complex purification process. Plant-derived nanovesicles with exosome-like morphology and similar delivery effects could be a new option for drug delivery. Celery exosome-like nanovesicles (CELNs), as a drug carrier, have higher cellular uptake efficiency and better tolerance as biotherapeutic roles verified in mice models. Encapsulating doxorubicin (DOX) into CELNs to construct engineered CELNs (CELNs-DOX) has proved to be more efficient in treating tumors than conventional synthetic carriers like liposome both in vitro and in vivo. This study proposes the emerging role of CELNs as a new-generation drug delivery carrier with distinct advantages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Puja Ghosh, Himja Tiwari, Jaya Lakkakula, Arpita Roy, Talha Bin Emran, Summya Rashid, Saad Alghamdi, Bodour S. Rajab, Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Ahad Amer Alsaiari, Rohit Sharma, Ahmad O. Babalghith
Summary: Despite advancements in the biomedical field, clinically approved cancer therapeutics are mostly limited to chemotherapy, surgery, and radiotherapy. There is a growing demand for targeted drug delivery using nanomaterials to mitigate the cardiotoxicity and side effects associated with current treatment strategies. In this review, the use of modified liposomes encapsulating the commonly used drug doxorubicin (DOX) is explored for the treatment of various types of cancer, showing potential for enhanced efficiency and site-specific drug delivery.
MATERIALS TODAY ADVANCES
(2022)
Article
Pharmacology & Pharmacy
Lourdes Valdivia, Lorena Garcia-Hevia, Manuel Banobre-Lopez, Juan Gallo, Rafael Valiente, Monica Lopez Fanarraga
Summary: Solid lipid particles (SLPs) can effectively encapsulate and release therapeutic agents over long periods, reducing the number of metastatic foci in the lung. In vitro kinetic studies show two distinctive drug release profiles, providing the possibility for further clinical applications.
Article
Biochemistry & Molecular Biology
Sonja Dragojevic, Lindsay Turner, Drazen Raucher
Summary: In this study, a macromolecular drug delivery system was examined for its ability to specifically deliver doxorubicin to cancer cells. The cytotoxicity and mechanism of action of two doxorubicin derivatives were compared in dox-responsive and dox-resistant cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ceren Kimna, Theresa Monika Lutz, Hongji Yan, Jian Song, Thomas Crouzier, Oliver Lieleg
Summary: A nanoparticle-based drug delivery system has been designed to release therapeutic agents into disease cells based on specific DNA sequences, showing potential for targeted treatments of specific diseases.
Article
Chemistry, Multidisciplinary
D. Sahoo, T. Mitra, K. Chakraborty, P. Sarkar
Summary: This study developed a new electric field responsive graphene oxide nanoparticle system for on-demand drug delivery, showcasing remote control of dual drugs (aspirin and doxorubicin) release and observing their synergistic antitumor activity in breast cancer cells in vitro.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Made Budiarta, Sathi Roy, Tobias Katenkamp, Neus Feliu, Tobias Beck
Summary: Due to its pharmacological properties, ferritin (Ftn) is used as a drug delivery vehicle to reduce the cardiotoxicity of doxorubicin (DOX) in chemotherapy. However, DOX encapsulation in Ftn faces challenges such as precipitation and low protein recovery yield. A new strategy using cysteine-maleimide conjugation for DOX encapsulation in Ftn is proposed and shown to be more efficient. The surface charges of Ftn variants affect the cytotoxicity, DOX loading, and cellular uptake mechanism.
Article
Chemistry, Multidisciplinary
Suainibhe Kelly, Maria H. Byrne, Susan J. Quinn, Jeremy C. Simpson
Summary: The pre-clinical evaluation of nanomaterials as therapeutic delivery vehicles requires careful assessment of cellular toxicity, often necessitating advanced in vitro cell models. An automated high-content screening microscopy approach allows for quantifying nanoparticle-induced toxicity in a three-dimensional multicellular tumor spheroid cell model, revealing individual cell responses within the spheroid structure. Subcellular resolution using fluorescent reporters can provide detailed information on nanoparticle-induced toxicity at the cellular level.
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Jong-Soo Choi, Jae-Won Park, Young-Bae Seu, Kyung-Oh Doh
Summary: FLLD, a folate-incorporated liposomal formulation of cholesteryl Dox, demonstrated enhanced cytotoxicity in FR-positive KB cells, promising as an anticancer drug with improved targeting effect compared to LLD.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jianqin Yan, Chan Shan, Caili Liang, Jinting Han, Bin He, Yong Sun, Kui Luo, Jing Chang, Xianwen Wang, Yan Liang
Summary: This study presents a smart multistage Trojan Horse-inspired BSA-coated liposome for enhancing tumor penetration and antitumor efficacy. The results show that the liposome effectively penetrates into tumor cells and exhibits the strongest tumor penetration and cytotoxicity.
Article
Pharmacology & Pharmacy
Wenhui Tao, Dongyang Zhao, Guanting Li, Lingxiao Li, Songhao Li, Hao Ye, Chutong Tian, Yutong Lu, Shuying Li, Yinghua Sun, Zhonggui He, Jin Sun
Summary: This study explores the use of platelet membrane-fusogenic liposomes, known as platesomes, to load hypoxia-activated prodrugs and photosensitizers for enhanced tumor drug delivery. The combination with vascular disrupting agents leads to tumor vascular collapse and occlusion, resulting in improved therapeutic efficacy and selective activation of tumor hypoxia.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Shenwu Zhang, Jing Wang, Zhiqiang Kong, Xinxin Sun, Zhonggui He, Bingjun Sun, Cong Luo, Jin Sun
Summary: Immunotherapy is a promising cancer treatment, but its efficacy for immune-cold tumors is not satisfactory. Photodynamic therapy can effectively induce immunogenic cell death, and the use of nanotechnology enhances the effectiveness of cancer immunotherapy. This article reviews recent advances in photodynamic therapy, nanotechnology, and immunogenic cell death, and discusses the prospects and challenges in this field.
Review
Engineering, Environmental
Yao Chen, Tongyao Zhao, Meiyu Bai, Tianrui Gu, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: Cancer is not a single disease, but a complex adaptive system involving inflammation, metabolism, and immunization. Combining multiple antineoplastic drugs offers advantages over monotherapy, but precise co-delivery into tumors remains challenging. Carrier-free nanoassemblies, engineered by small molecules, have emerged as a promising platform for co-delivery of anticancer drugs. This article provides an overview of the latest developments in this field, summarizing trends in nanomedicines, analyzing assembly mechanisms and drug release characteristics, and highlighting the prospects and challenges in clinical translation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Mengchi Sun, Weiyue Ban, Hao Ling, Xiang Yu, Zhonggui He, Qikun Jiang, Jin Sun
Summary: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and recurrent disease of the gastrointestinal tract. Current approaches lack precision in drug delivery to the inflammatory site, leading to long-term medication and significant side effects. Recent advancements in nanotechnology-based nanomedicines (NMs) and prodrug strategies have shown promise in improving IBD treatment efficacy and reducing side effects. This article outlines the latest advances in the intersection of IBD treatment, nanotherapeutics, and prodrug therapy.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Mengchi Sun, Shihua Yang, Hanwei Huang, Peng Gao, Siwei Pan, Zhenguo Cheng, Zhonggui He, Zhenning Wang, Jin Sun, Funan Liu
Summary: This study proposes a bacteria-assisted targeting system for oncolytic viruses (OVs) to enhance their concentration within tumors. By conjugating liposome-cloaked oncolytic adenoviruses (OAs) onto tumor-homing Escherichia coli, the enrichment of OAs within tumors is significantly increased. In addition, this system also augments antitumor immune responses through bacterial-viral interactions.
Article
Chemistry, Multidisciplinary
Qi Lu, Hao Ye, Kaiyuan Wang, Jian Zhao, Helin Wang, Jiaxuan Song, Xiaoyuan Fan, Yutong Lu, Liping Cao, Bin Wan, Haotian Zhang, Zhonggui He, Jin Sun
Summary: In this study, researchers proposed a method to reduce tumor relapse and metastasis by utilizing the targeting capability of platelets towards tumor cells. Bioengineered platelets showed promising results in reducing postoperative tumor recurrence and metastasis, thus prolonging the survival time of patients.
Article
Chemistry, Physical
Yanxian Hou, Yafei Kuang, Qikun Jiang, Shuang Zhou, Jiang Yu, Zhonggui He, Jin Sun
Summary: This study demonstrates the design of an arginine-peptide complex that co-assembles with THPP into NPs, enabling rapid release of photosensitizers and efficient generation of NO to enhance PDT efficacy.
Article
Engineering, Biomedical
Yixin Sun, Simeng Wang, Yaqi Li, Danping Wang, Yu Zhang, Haotian Zhang, Hongrui Lei, Xiaohong Liu, Jin Sun, Bingjun Sun, Zhonggui He
Summary: Prodrug-based nanoassemblies, combining prodrug technology and nanocarriers, show great promise in cancer treatment. The chemical structure of prodrugs is closely related to their antitumor efficacy and safety, and the relationship between them needs further exploration.
ACTA BIOMATERIALIA
(2023)
Article
Medicine, Research & Experimental
Chutong Tian, Jin Sun, Mingyang Zhang, Chunlin Guo, Yifan Miao, Zhonggui He
Summary: In this study, a lipophilic disulfide-bridged linoleic prodrug (PTX-S-S-LA) was synthesized and efficiently incorporated into a self-microemulsifying drug delivery system (SMEDDS) to facilitate the oral absorption of paclitaxel (PTX). The prodrug SMEDDS showed higher drug loading efficiency and stability compared to parent PTX, and significantly increased drug partition in the intestinal micellar aqueous phase. Moreover, SMEDDS enhanced gastrointestinal biological adhesion and lymphatic transport, resulting in improved antitumor efficiency without significant gastrointestinal toxicity. Overall, the combination of PTX-S-S-LA and SMEDDS provides a promising approach for effective oral delivery of PTX.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Xiaoyuan Fan, Kaiyuan Wang, Qi Lu, Yutong Lu, Jin Sun
Summary: Immunotherapy aims to activate the immune system to treat cancer, but its effectiveness in clinical applications is still limited. Cell-based drug delivery systems have the potential to enhance the efficacy of cancer immunotherapy and play important roles.
Article
Medicine, Research & Experimental
Ximing Zhang, Fangxue Zhao, Jing Feng, Cong Chen, Zhonggui He, Mengchi Sun, Jin Sun
Summary: In this study, an ionizable PTX prodrug (PTXP) was designed to achieve remote loading of liposomal formulations. Compared to marketable PTX liposomes, PTXP liposomes showed higher loading efficiency and encapsulation efficiency, as well as demonstrated stability, prolonged circulation time, high tumor site accumulation, potent anti-tumor effects, and safety in vitro and in vivo.
MOLECULAR PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Yi-fan Miao, Qing Ye, Ming-yang Zhang, Lin Gao, Xi-yan Wang, Wen-xin Zhong, Zi-xuan Wang, Zhong-gui He, Chu-tong Tian, Jin Sun
Summary: Due to the serious side effects of intravenous Taxol, the development of an oral chemotherapeutic strategy for paclitaxel (PTX) delivery is highly anticipated. This study explores a series of triglyceride-mimetic prodrugs of PTX with different fatty acid structures to enhance oral antitumor effect and guide the design of similar prodrugs. The results show that the length of fatty acids plays a significant role in in vitro intestinal digestion behavior, lymph transport efficiency, and plasma pharmacokinetics, while the degree of unsaturation has a negligible impact. These findings provide a theoretical basis for the rational design of TG-like PTX prodrugs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xiaofeng Chen, Kaiyuan Wang, Fangming Liang, Ruiqi Jiang, Jin Sun
Summary: Exosomes, as potential drug delivery systems, show promising prospects in cancer treatment. Researchers are exploring different modification strategies to improve the targeting ability of exosomes and enhance their therapeutic effect while reducing toxicity to normal cells.
PROGRESS IN CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Chang Li, Yubo Liu, Dan Li, Qiu Wang, Shuang Zhou, Haotian Zhang, Yongjun Wang, Zhonggui He, Hongzhuo Liu, Jin Sun
Summary: This study introduced a novel injectable hydrogel scaffold, PQ/PB-Gel, for local delivery of small-molecule inhibitor PQ912 to inhibit local tumor recurrence. The hydrogel system effectively prevented the generation of "don't eat me" signals, activated systemic immune response, and induced the formation of memory T lymphocytes.
Article
Pharmacology & Pharmacy
Mengchi Sun, Hailun Jiang, Tian Liu, Xiao Tan, Qikun Jiang, Bingjun Sun, Yulong Zheng, Gang Wang, Yang Wang, Maosheng Cheng, Zhonggui He, Jin Sun
Summary: A novel chemo-photodynamic both-in-one nano-drug delivery system was reported for the effective treatment of breast tumor and prevention of lung metastasis, showing promising potential for the treatment of breast cancer patients.
ACTA PHARMACEUTICA SINICA B
(2022)