Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 5, Issue 1, Pages 390-401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b01196
Keywords
nanoparticle; amyloid; polyglutamine; autophagy; neurodegenerative disease
Categories
Funding
- DST Nano Mission [SR/NM/NB/1009/2016]
- CSIR Government of India [02(0249)15/EMR-II]
- IACS
Ask authors/readers for more resources
Inhibiting protein aggregation under intra-/extracellular space and clearing protein aggregates from the brain are two critical issues for the treatment of various neurodegenerative diseases. Although a variety of anti-amyloidogenic chemicals/biochemicals have been identified for inhibiting such protein aggregation, clearing protein aggregates is a challenging issue. Here we report a designed biopolymer micelle of 15-30 nm hydrodynamic size that can clear protein aggregates from cells via an up-regulated autophagy process. The polymer has a polyaspartic acid backbone and is functionalized with fatty amine, arginine, and primary amine for inducing self-assembly, enhancing cell uptake, and up-regulating autophagy processes, respectively. The polymer micelle (PM) enters into the cell via lipid raft endocytosis, is transported to the perinuclear region where the protein oligomer/aggregate predominantly localizes, clears aggregated protein from the cell, and enhances the cell's survival against toxic protein aggregates. The designed PM may be used as a drug delivery carrier for anti-amyloidogenic drugs for enhanced efficacy in the treatment of neurodegenerative diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available