Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice

(2019) Yang Yang et al.   Biomed Research International

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

(2019) Daniel Moreno-Blas et al.   Aging-US

High mobility group box‐1‐toll‐like receptor 4‐phosphatidylinositol 3‐kinase/protein kinase B‐mediated generation of matrix metalloproteinase‐9 in the dorsal root ganglion promotes chemotherapy‐induced peripheral neuropathy

(2019) Haibo Gu et al.   INTERNATIONAL JOURNAL OF CANCER

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

(2019) Shoma Ishikawa et al.   AGING CELL

DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain

(2019) Laura Brandolini et al.   Scientific Reports

Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells

(2018) Irina O. Vassilieva et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two-Step Senescence-Focused Cancer Therapies

(2018) Cynthia J. Sieben et al.   TRENDS IN CELL BIOLOGY

Cellular Senescence: The Sought or the Unwanted?

(2018) Yu Sun et al.   TRENDS IN MOLECULAR MEDICINE

Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice

(2018) Raquel Tonello et al.   JOURNAL OF PAIN

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain

(2017) Temugin Berta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

(2017) Karen Krukowski et al.   PAIN

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

CXCR1/2 pathways in paclitaxel-induced neuropathic pain

(2017) Brandolini Laura et al.   Oncotarget

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons

(2017) Yu Tang et al.   Frontiers in Molecular Neuroscience

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Interleukin-6: an emerging regulator of pathological pain

(2016) Ya-Qun Zhou et al.   Journal of Neuroinflammation

The Dorsal Root Ganglion in the Pathogenesis of Chronic Neuropathic Pain

(2016) Daipayan Guha et al.   NEUROSURGERY

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Behavioral signs of pain and functional impairment in a mouse model of osteogenesis imperfecta

(2015) Dareen M. Abdelaziz et al.   BONE

Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain

(2015) Nurul Atiqah Zulazmi et al.   FITOTERAPIA

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ

(2015) Karen Krukowski et al.   PAIN

Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model

(2014) Karim Raafat et al.   ARCHIVES OF PHARMACAL RESEARCH

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice

(2014) Wolfgang Boehmerle et al.   Scientific Reports

DNA damage response in peripheral nervous system: Coping with cancer therapy-induced DNA lesions

(2013) Ella W. Englander   DNA REPAIR

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve

(2013) Petr Dubový et al.   Journal of Neuroinflammation

Atypical Protein Kinase C and Par3 Are Required for Proteoglycan-Induced Axon Growth Inhibition

(2013) S.-i. Lee et al.   JOURNAL OF NEUROSCIENCE

A Novel and Selective Poly (ADP-Ribose) Polymerase Inhibitor Ameliorates Chemotherapy-Induced Painful Neuropathy

(2013) Lauren E. Ta et al.   PLoS One

Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)

(2013) Yaqin Han et al.   Frontiers in Pharmacology

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice

(2012) Ahmet Ulugol et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy

(2010) N. Uceyler et al.   NEUROLOGY

p38 MAPK and JNK Antagonistically Control Senescence and Cytoplasmic p16INK4A Expression in Doxorubicin-Treated Endothelial Progenitor Cells

(2010) Paolo Spallarossa et al.   PLoS One

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Mice with Cisplatin and Oxaliplatin-Induced Painful Neuropathy Develop Distinct Early Responses to Thermal Stimuli

(2009) Lauren E Ta et al.   Molecular Pain

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY