Long-term Neuroglial Cocultures as a Brain Aging Model: Hallmarks of Senescence, MicroRNA Expression Profiles, and Comparison With In Vivo Models

Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice

(2016) Amit Khanna et al.   Aging-US

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

(2016) H. Dorota Halicka et al.   Aging-US

Phosphorylation of Histone H2AX in the Mouse Brain from Development to Senescence

(2014) Serena Barral et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging

(2013) Weiguo Dong et al.   MEDICAL SCIENCE MONITOR

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Genome-wide miRNA signatures of human longevity

(2012) Abdou ElSharawy et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Changes in advanced oxidation protein products, advanced glycation end products, and s-nitrosylated proteins, in patients affected by polycythemia vera and essential thrombocythemia

(2012) Caterina Musolino et al.   CLINICAL BIOCHEMISTRY

Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum

(2012) T. Genade et al.   EXPERIMENTAL GERONTOLOGY

Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts

(2012) V. Pitozzi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Long-Term Dietary Extra-Virgin Olive Oil Rich in Polyphenols Reverses Age-Related Dysfunctions in Motor Coordination and Contextual Memory in Mice: Role of Oxidative Stress

(2012) Vanessa Pitozzi et al.   REJUVENATION RESEARCH

After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders

(2011) Kilian Huber et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Endogenous amyloidogenesis in long-term rat hippocampal cell cultures

(2011) Sarah J Bertrand et al.   BMC NEUROSCIENCE

Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease

(2011) Anton Rahmadi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

microRNA-34c is a novel target to treat dementias

(2011) Athanasios Zovoilis et al.   EMBO JOURNAL

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology

(2011) Giordano Lippi et al.   JOURNAL OF CELL BIOLOGY

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

(2010) Matthias Hackl et al.   AGING CELL

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

(2010) David O Kennedy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

(2010) M. Somel et al.   GENOME RESEARCH

Protective Effects of Resveratrol Against Senescence-Associated Changes in Cultured Human Fibroblasts

(2010) Lisa Giovannelli et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age

(2010) Nicole Noren Hooten et al.   PLoS One

Cultured cerebellar granule neurons as an in vitro aging model: Topoisomerase IIβ as an additional biomarker in DNA repair and aging

(2010) M. Uday Bhanu et al.   TOXICOLOGY IN VITRO

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

(2009) O. O. Ogunshola et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic Control of MicroRNA Expression and Aging

(2009) Ruqiang Liang et al.   CURRENT GENOMICS

Alterations in microRNA expression in stress-induced cellular senescence

(2009) Guorong Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain

(2009) Na Li et al.   NEUROBIOLOGY OF AGING

Resveratrol preserves cerebrovascular density and cognitive function in aging mice

(2009) Charlotte Oomen   Frontiers in Aging Neuroscience

Reactive oxidant species and oxidation of protein and heamoglobin as biomarkers of susceptibility to stress caused by chloramphenicol

(2008) Viviana Correa-Salde et al.   BIOMEDICINE & PHARMACOTHERAPY

p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation

(2008) Ran Brosh et al.   Molecular Systems Biology

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA