EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload

(2019) Daniela Miranda-Silva et al.   Scientific Reports

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease

(2018) Trond Aasen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microtubular remodeling and decreased expression of Nav1.5 with enhanced EHD4 in cells from the infarcted heart

(2018) Wen Dun et al.   LIFE SCIENCES

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

(2015) Tania Martins-Marques et al.   BIOCHEMICAL JOURNAL

To beat or not to beat: degradation of Cx43 imposes the heart rhythm: Figure 1

(2015) Tânia Martins-Marques et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

(2015) Tânia Martins-Marques et al.   BIOCHIMIE

Synergistic role of ADP and Ca2+in diastolic myocardial stiffness

(2015) Vasco Sequeira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

(2015) Tania Martins-Marques et al.   MOLECULAR & CELLULAR PROTEOMICS

Endosome-based protein trafficking and Ca2+ homeostasis in the heart

(2015) Jerry Curran et al.   Frontiers in Physiology

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

(2014) Teresa M. Ribeiro-Rodrigues et al.   FASEB JOURNAL

EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368

(2014) John T. Fong et al.   FEBS LETTERS

Protein Kinase Cδ-mediated Phosphorylation of Connexin43 Gap Junction Channels Causes Movement within Gap Junctions followed by Vesicle Internalization and Protein Degradation

(2014) Angela C. Cone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications of Coronary Artery Disease in Heart Failure With Preserved Ejection Fraction

(2014) Seok-Jae Hwang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line

(2014) Priyanthi Dias et al.   PLoS One

A 14-3-3 Mode-1 Binding Motif Initiates Gap Junction Internalization During Acute Cardiac Ischemia

(2014) James W. Smyth et al.   TRAFFIC

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking

(2014) Sathya D. Unudurthi et al.   Frontiers in Physiology

Antiadrenergic effect of adenosine involves connexin 43 turn-over in H9c2 cells

(2013) Ada Popolo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

(2013) C. A. Dunn et al.   JOURNAL OF CELL SCIENCE

Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis

(2013) John T. Fong et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

(2011) Steve Catarino et al.   BIOCHEMICAL JOURNAL

Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes

(2011) Diego Rodríguez-Penas et al.   BIOCHEMICAL PHARMACOLOGY

Functional consequences of abnormal Cx43 expression in the heart

(2011) Magda S.C. Fontes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions

(2011) Sarah Mollerup et al.   CELL COMMUNICATION AND ADHESION

EH Domain Proteins Regulate Cardiac Membrane Protein Targeting

(2010) Hjalti Gudmundsson et al.   CIRCULATION RESEARCH

Alterations of EHD1/EHD4 Protein Levels Interfere with L1/NgCAM Endocytosis in Neurons and Disrupt Axonal Targeting

(2010) C. C. C. Yap et al.   JOURNAL OF NEUROSCIENCE

EHD proteins: key conductors of endocytic transport

(2010) Naava Naslavsky et al.   TRENDS IN CELL BIOLOGY

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

(2009) Henrique Girão et al.   EXPERIMENTAL CELL RESEARCH

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101

(2009) E. Leithe et al.   JOURNAL OF CELL SCIENCE

Inhibitors of clathrin-dependent endocytosis enhance TGF  signaling and responses

(2009) C.-L. Chen et al.   JOURNAL OF CELL SCIENCE

EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology

(2009) N. Naslavsky et al.   JOURNAL OF CELL SCIENCE

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis

(2008) Solveig Sirnes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery

(2008) Anna M. Gumpert et al.   FEBS LETTERS