Fueling Cell Invasion through Extracellular Matrix

Oxidative phosphorylation promotes primary melanoma invasion

(2020) Amel Salhi et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

(2020) Robinson Arce-Molina et al.   eLife

Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

(2020) R. Commander et al.   Nature Communications

Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites

(2020) Audrey C. Brown et al.   Scientific Reports

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

(2020) Elizabeth Foxall et al.   Cell Reports

The chemokine CCL7 regulates invadopodia maturation and MMP-9 mediated collagen degradation in liver-metastatic carcinoma cells

(2020) Shu Qi et al.   CANCER LETTERS

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

(2020) Nina Marie Pedersen et al.   JOURNAL OF CELL BIOLOGY

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

(2020) Ahmad A. Cluntun et al.   Cell Metabolism

Neuronal ICAM-5 Plays a Neuroprotective Role in Progressive Neurodegeneration

(2019) Katharina Birkner et al.   Frontiers in Neurology

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

(2019) Mark A. Lobas et al.   Nature Communications

Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells

(2019) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

Green fluorescent protein-based glucose indicators report glucose dynamics in living cells

(2019) Marie Mita et al.   ANALYTICAL CHEMISTRY

Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor

(2019) Carlos Manlio Díaz‐García et al.   JOURNAL OF NEUROSCIENCE RESEARCH

On the energy efficiency of cell migration in diverse physical environments

(2019) Yizeng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

(2019) Matthew R. Zanotelli et al.   Nature Communications

Modular actin nano-architecture enables podosome protrusion and mechanosensing

(2019) Koen van den Dries et al.   Nature Communications

The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis

(2019) Bahar Yetkin-Arik et al.   Scientific Reports

Comparison of Mitochondrial Superoxide Detection Ex Vivo/In Vivo by mitoSOX HPLC Method with Classical Assays in Three Different Animal Models of Oxidative Stress

(2019) Sanela Kalinovic et al.   Antioxidants

Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia

(2019) Rebecca McLennan et al.   DEVELOPMENT

A developmental gene regulatory network for C. elegans anchor cell invasion

(2019) Taylor N. Medwig-Kinney et al.   DEVELOPMENT

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

(2019) B. Pajak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation

(2019) L. Gándara et al.   Scientific Reports

Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression

(2018) Dejuan Yang et al.   Cell Communication and Signaling

Intravital microscopy of collective invasion plasticity in breast cancer

(2018) Olga Ilina et al.   Disease Models & Mechanisms

Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury

(2018) Jesica Frik et al.   EMBO REPORTS

Invading, Leading and Navigating Cells inCaenorhabditis elegans: Insights into Cell Movementin Vivo

(2018) David R. Sherwood et al.   GENETICS

Regulation of ATP utilization during metastatic cell migration by collagen architecture

(2018) Matthew R. Zanotelli et al.   MOLECULAR BIOLOGY OF THE CELL

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

(2018) Elvira Infante et al.   Nature Communications

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

(2018) Maomao Zhang et al.   Cancer Discovery

Glucose monitoring in living cells with single fluorescent protein-based sensors

(2018) Hanyang Hu et al.   RSC Advances

Ca 2+ -Induced Mitochondrial ROS Regulate the Early Embryonic Cell Cycle

(2018) Yue Han et al.   Cell Reports

Invading, Leading and Navigating Cells inCaenorhabditis elegans: Insights into Cell Movementin Vivo

(2018) David R. Sherwood et al.   GENETICS

Triple Fluorescence staining to Evaluate Mechanism-based Apoptosis following Chemotherapeutic and Targeted Anti-cancer Drugs in Live Tumor Cells

(2018) Pradip De et al.   Scientific Reports

The enigmatic ATP supply of the endoplasmic reticulum

(2018) Maria R. Depaoli et al.   BIOLOGICAL REVIEWS

Mitochondrial dynamics and metastasis

(2018) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

Forces drive basement membrane invasion inCaenorhabditis elegans

(2018) Rodrigo Cáceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

(2017) Pavlo Gritsenko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration

(2017) Max-Hinderk Schuler et al.   MOLECULAR BIOLOGY OF THE CELL

Nutrient acquisition strategies of mammalian cells

(2017) Wilhelm Palm et al.   NATURE

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming

(2017) Shujuan Sun et al.   Cell Death & Disease

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

(2017) Mohammed Khurshed et al.   Oncotarget

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

(2016) Brian Cunniff et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function

(2016) SoRi Jang et al.   NEURON

Biosensor reveals multiple sources for mitochondrial NAD+

(2016) X. A. Cambronne et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation

(2016) Lauren L. Lohmer et al.   PLoS Genetics

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane

(2016) Meghan A. Morrissey et al.   PLoS Genetics

Dendritic mitochondria reach stable positions during circuit development

(2016) Michelle C Faits et al.   eLife

BTeam, a Novel BRET-based Biosensor for the Accurate Quantification of ATP Concentration within Living Cells

(2016) Tomoki Yoshida et al.   Scientific Reports

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Extracellular Metabolic Energetics Can Promote Cancer Progression

(2015) Jia Min Loo et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

(2014) Stephanie M Stanford et al.   ANNALS OF THE RHEUMATIC DISEASES

Three αSNAP and 10 ATP Molecules Are Used in SNARE Complex Disassembly byN-ethylmaleimide-sensitive Factor (NSF)

(2014) Niket Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY