A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation

One hundred years of Drosophila cancer research: no longer in solitude

(2019) Santiago Nahuel Villegas   Disease Models & Mechanisms

Cell-Autonomous Metabolic Reprogramming in Hypoxia

(2018) Luana Schito et al.   TRENDS IN CELL BIOLOGY

Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer

(2018) Teresa Eichenlaub et al.   CURRENT BIOLOGY

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

Zonda is a novel early component of the autophagy pathway in Drosophila

(2017) Mariana Melani et al.   MOLECULAR BIOLOGY OF THE CELL

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle

(2016) Vera Slaninova et al.   Open Biology

In vivo genetic dissection of tumor growth and the Warburg effect

(2016) Cheng-Wei Wang et al.   eLife

Developmental changes in hypoxic exposure and responses to anoxia in Drosophila melanogaster

(2015) V. Callier et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

(2015) Shruti Desai et al.   Oncotarget

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

(2014) John C. Schell et al.   MOLECULAR CELL

Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate

(2014) Alejandro San Martín et al.   PLoS One

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

(2014) GuemHee Baek et al.   Cell Reports

Quantitative monitoring of 2-oxoglutarate in Escherichia coli cells by a fluorescence resonance energy transfer-based biosensor

(2013) Chang Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy

(2013) Ping Miao et al.   IUBMB LIFE

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism

(2012) Jessica P Monserrate et al.   BMC BIOLOGY

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Stable expression of FRET biosensors: A new light in cancer research

(2011) Kazuhiro Aoki et al.   CANCER SCIENCE

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Triggering and amplification of insulin secretion by dimethyl α-ketoglutarate, a membrane permeable α-ketoglutarate analogue

(2009) Michael Willenborg et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE