A decade of progress in tissue engineering

Reverse Engineering Human Pathophysiology with Organs-on-Chips

(2016) Donald E. Ingber   CELL

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

(2016) Hyun-Wook Kang et al.   NATURE BIOTECHNOLOGY

Biomimetic 4D printing

(2016) A. Sydney Gladman et al.   NATURE MATERIALS

Optogenetic skeletal muscle-powered adaptive biological machines

(2016) Ritu Raman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designer protein delivery: From natural to engineered affinity-controlled release systems

(2016) M. M. Pakulska et al.   SCIENCE

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Aligned Carbon Nanotube-Based Flexible Gel Substrates for Engineering Biohybrid Tissue Actuators

(2015) Su Ryon Shin et al.   ADVANCED FUNCTIONAL MATERIALS

Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

(2015) Cristina Colosi et al.   ADVANCED MATERIALS

Direct 3D Printing of Shear-Thinning Hydrogels into Self-Healing Hydrogels

(2015) Christopher B. Highley et al.   ADVANCED MATERIALS

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Freeform inkjet printing of cellular structures with bifurcations

(2015) Kyle Christensen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Seeking the right context for evaluating nanomedicine: from tissue models in petri dishes to microfluidic organs-on-a-chip

(2015) Yu Shrike Zhang et al.   Nanomedicine

New life for pig-to-human transplants

(2015) Sara Reardon   NATURE

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

Programmed synthesis of three-dimensional tissues

(2015) Michael E Todhunter et al.   NATURE METHODS

Supercooling preservation and transplantation of the rat liver

(2015) Bote G Bruinsma et al.   Nature Protocols

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Active mixing of complex fluids at the microscale

(2015) Thomas J. Ober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Writing in the granular gel medium

(2015) T. Bhattacharjee et al.   Science Advances

Bioreactor technologies to support liver function in vitro

(2014) Mohammad R. Ebrahimkhani et al.   ADVANCED DRUG DELIVERY REVIEWS

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Creating perfused functional vascular channels using 3D bio-printing technology

(2014) Vivian K. Lee et al.   BIOMATERIALS

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

(2014) Luiz E. Bertassoni et al.   LAB ON A CHIP

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

25th Anniversary Article: Engineering Hydrogels for Biofabrication

(2013) Jos Malda et al.   ADVANCED MATERIALS

A Perspective on Immunomodulation and Tissue Repair

(2013) Nassir Mokarram et al.   ANNALS OF BIOMEDICAL ENGINEERING

Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering

(2013) Saik-Kia Goh et al.   BIOMATERIALS

Decellularization for whole organ bioengineering

(2013) J E Arenas-Herrera et al.   Biomedical Materials

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

(2013) O. Levy et al.   BLOOD

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Regeneration and experimental orthotopic transplantation of a bioengineered kidney

(2013) Jeremy J Song et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model

(2013) J. M. Fishman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

(2013) M. M. Martino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

DNA-directed self-assembly of shape-controlled hydrogels

(2013) Hao Qi et al.   Nature Communications

Decellularization methods of porcine kidneys for whole organ engineering using a high-throughput system

(2012) David C. Sullivan et al.   BIOMATERIALS

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

(2012) Bryan N. Brown et al.   BIOMATERIALS

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

Bioprinting of a mechanically enhanced three-dimensional dual cell-laden construct for osteochondral tissue engineering using a multi-head tissue/organ building system

(2012) Jin-Hyung Shim et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Complex shapes self-assembled from single-stranded DNA tiles

(2012) Bryan Wei et al.   NATURE

A tissue-engineered jellyfish with biomimetic propulsion

(2012) Janna C Nawroth et al.   NATURE BIOTECHNOLOGY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Three-Dimensional Structures Self-Assembled from DNA Bricks

(2012) Y. Ke et al.   SCIENCE

Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds

(2012) Malar A. Azagarsamy et al.   ACS Macro Letters

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

Whole-Organ Tissue Engineering: Decellularization and Recellularization of Three-Dimensional Matrix Scaffolds

(2011) Stephen F. Badylak et al.   Annual Review of Biomedical Engineering

Engineered cell homing

(2011) D. Sarkar et al.   BLOOD

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Organ engineering based on decellularized matrix scaffolds

(2011) Jeremy J. Song et al.   TRENDS IN MOLECULAR MEDICINE

Metabolic preconditioning of cells with AICAR-riboside: Improved cryopreservation and cell-type specific impacts on energetics and proliferation

(2010) Michael A. Menze et al.   CRYOBIOLOGY

The use of whole organ decellularization for the generation of a vascularized liver organoid

(2010) Pedro M. Baptista et al.   HEPATOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

(2010) Basak E Uygun et al.   NATURE MEDICINE

Regeneration and orthotopic transplantation of a bioartificial lung

(2010) Harald C Ott et al.   NATURE MEDICINE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

Surface-directed assembly of cell-laden microgels

(2009) Yanan Du et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mesenchymal Stem Cell Homing: The Devil Is in the Details

(2009) Jeffrey M. Karp et al.   Cell Stem Cell

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Progress in Tissue Engineering

(2009) Ali Khademhosseini et al.   SCIENTIFIC AMERICAN

On the mechanisms of biocompatibility

(2008) David F. Williams   BIOMATERIALS

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE

Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs

(2008) Y. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY