Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation

Antibody-Drug Conjugate-Based Therapeutics: State of the Science

(2019) Michael J Birrer et al.   JNCI-Journal of the National Cancer Institute

Randomized Phase III Study of Alisertib or Investigator’s Choice (Selected Single Agent) in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma

(2019) Owen A. O’Connor et al.   JOURNAL OF CLINICAL ONCOLOGY

Bioprocess development of antibody-drug conjugate production for cancer treatment

(2018) Jianfa Ou et al.   PLoS One

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

(2018) Gabriella Andriolo et al.   Frontiers in Physiology

Intracellular transport is accelerated in early apoptotic cells

(2018) Bo Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Exosomes for Cancer Therapy

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy

(2016) Guojun Chen et al.   BIOMATERIALS

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Interaction of poly(ethylene glycol)-conjugated phospholipids with supported lipid membranes and their influence on protein adsorption

(2016) Toshihiro Yamamoto et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

A novel affinity-based method for the isolation of highly purified extracellular vesicles

(2016) Wataru Nakai et al.   Scientific Reports

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome

(2015) Tian-yun Wang et al.   Scientific Reports

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

(2014) Kasper Bendix Johnsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

(2011) R. B. Rountree et al.   CANCER RESEARCH

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Increasing vaccine potency through exosome antigen targeting

(2011) Zachary C. Hartman et al.   VACCINE

The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21

(2010) Deok-Soo Son et al.   CANCER BIOLOGY & THERAPY

Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide

(2010) Hideki Mizutani et al.   CANCER SCIENCE

Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells

(2010) Jyoti Panicker et al.   CELL CYCLE

Signaling Mechanisms in Neuroendocrine Tumors as Targets for Therapy

(2010) Barbara Zarebczan et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Downregulation of EGFR by a novel multivalent nanobody-liposome platform

(2010) Sabrina Oliveira et al.   JOURNAL OF CONTROLLED RELEASE

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY