Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: So near and yet so far

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Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

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Antitumor-specific T-cell responses induced by oncolytic adenovirus ONCOS-102 (AdV5/3-D24-GM-CSF) in peritoneal mesothelioma mouse model

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Oncolytic Virus Combination Therapy: Killing One Bird with Two Stones

(2018) Nikolas Tim Martin et al.   MOLECULAR THERAPY

New Optical Imaging Reporter-labeled Anaplastic Thyroid Cancer-Derived Extracellular Vesicles as a Platform for In Vivo Tumor Targeting in a Mouse Model

(2018) Prakash Gangadaran et al.   Scientific Reports

Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection

(2017) Rocio Garcia-Carbonero et al.   Journal for ImmunoTherapy of Cancer

Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102 – Support for clinical studies on advanced cancer treatment

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Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

(2016) Stefano Fais et al.   ACS Nano

Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy

(2016) Li Ran et al.   BIOMATERIALS

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

(2016) Stephan Stremersch et al.   JOURNAL OF CONTROLLED RELEASE

Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity

(2016) Mari Hirvinen et al.   Molecular Therapy-Oncolytics

Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

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Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

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Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Encapsulation of adenovirus serotype 5 in anionic lecithin liposomes using a bead-based immunoprecipitation technique enhances transfection efficiency

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Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

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Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8+T-cell response, prominent infiltration of CD8+lymphocytes and Th1 type polarization

(2014) Tuuli Ranki et al.   OncoImmunology

Combinatorial treatment with oncolytic adenovirus and helper-dependent adenovirus augments adenoviral cancer gene therapy

(2014) Lisa Farzad et al.   Molecular Therapy-Oncolytics

Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer

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Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF-Coding Oncolytic Adenovirus

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Extracellular Vesicles – Biomarkers and Effectors of the Cellular Interactome in Cancer

(2013) Janusz Rak   Frontiers in Pharmacology

Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus

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The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection

(2010) Noriyuki Yamada et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer

(2010) C. Comins et al.   CLINICAL CANCER RESEARCH

An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood

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Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

(2010) Anniina Koski et al.   MOLECULAR THERAPY

Efficacy of Systemically Administered Oncolytic Vaccinia Virotherapy for Malignant Gliomas Is Enhanced by Combination Therapy with Rapamycin or Cyclophosphamide

(2009) X. Q. Lun et al.   CLINICAL CANCER RESEARCH

Current Issues and Future Directions of Oncolytic Adenoviruses

(2009) Masato Yamamoto et al.   MOLECULAR THERAPY

Predominant infiltration of macrophages and CD8+T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

(2008) Osamu Kawai et al.   CANCER