Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

(2016) Taral R. Lunavat et al.   BIOMATERIALS

DNA in serum extracellular vesicles is stable under different storage conditions

(2016) Yang Jin et al.   BMC CANCER

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

(2016) Xuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

(2016) Kasper Bendix Johnsen et al.   CYTOTECHNOLOGY

Exosome-associated AAV vector as a robust and convenient neuroscience tool

(2016) E Hudry et al.   GENE THERAPY

A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism

(2016) Xi Lan et al.   HEPATOLOGY

Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats

(2016) Xin Qi et al.   International Journal of Biological Sciences

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

(2016) Stephan Stremersch et al.   JOURNAL OF CONTROLLED RELEASE

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

(2016) Dominique Ingato et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic and diagnostic applications of extracellular vesicles

(2016) Stephan Stremersch et al.   JOURNAL OF CONTROLLED RELEASE

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Toxicity and inflammatory response in Swiss albino mice after intraperitoneal and oral administration of polyurethane nanoparticles

(2016) Adny H. Silva et al.   TOXICOLOGY LETTERS

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

(2016) Lingling Jiang et al.   Nature Communications

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

(2016) Mei-Ju Su et al.   Scientific Reports

Identification and Characterization of 293T Cell-Derived Exosomes by Profiling the Protein, mRNA and MicroRNA Components

(2016) Jing Li et al.   PLoS One

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Gram-negative and Gram-positive bacterial extracellular vesicles

(2015) Ji Hyun Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

(2015) Yuchen Liu et al.   Scientific Reports

Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice

(2015) Guo-wen Hu et al.   Stem Cell Research & Therapy

Cell or Cell Membrane-Based Drug Delivery Systems

(2015) Songwei Tan et al.   Theranostics

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

(2015) Kirsten Ridder et al.   OncoImmunology

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

(2014) Keisuke Shimbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

(2014) Zoltán Giricz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Could bioengineered exosome-mimetic nanovesicles be an efficient strategy for the delivery of chemotherapeutics?

(2014) Su Chul Jang et al.   Nanomedicine

Inhibition of porcine reproductive and respiratory syndrome virus infection by recombinant adenovirus- and/or exosome-delivered the artificial microRNAs targeting sialoadhesin and CD163 receptors

(2014) Li Zhu et al.   Virology Journal

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Immunization with Escherichia coli Outer Membrane Vesicles Protects Bacteria-Induced Lethality via Th1 and Th17 Cell Responses

(2013) O. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

(2013) Songwen Ju et al.   MOLECULAR THERAPY

Solid lipid nanoparticles induced hematological changes and inflammatory response in mice

(2013) Adny Henrique Silva et al.   Nanotoxicology

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

(2013) Jin Cai et al.   Journal of Molecular Cell Biology

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

(2012) Casey A Maguire et al.   MOLECULAR THERAPY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

(2012) J. Bennett et al.   Science Translational Medicine

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

(2012) Mehmet Fatih Bolukbasi et al.   Molecular Therapy-Nucleic Acids

Microvesicles: Messengers and mediators of tumor progression

(2011) Khalid Al-Nedawi et al.   CELL CYCLE

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Role of anti-oncomirs miR-143 and -145 in human colorectal tumors

(2010) Y Akao et al.   CANCER GENE THERAPY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages

(2010) Yukihiro Akao et al.   MOLECULAR THERAPY

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

(2009) Céline Beauvillain et al.   VACCINE

Integration Site Selection by Retroviral Vectors: Molecular Mechanism and Clinical Consequences

(2008) René Daniel et al.   HUMAN GENE THERAPY

Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool

(2008) J. García-Castro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

(2008) Melissa Piper Hunter et al.   PLoS One

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE