The Jak/STAT pathway: A focus on pain in rheumatoid arthritis

Granulocyte-macrophage colony stimulating factor as an indirect mediator of nociceptor activation and pain

(2020) Damini Tewari et al.   JOURNAL OF NEUROSCIENCE

Interleukin-6 contributes to initiation of neuronal regeneration program in the remote dorsal root ganglia neurons after sciatic nerve injury

(2019) Petr Dubový et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF induced pain

(2019) Fan Zhang et al.   JOURNAL OF NEUROSCIENCE

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

Achieving Pain Control in Rheumatoid Arthritis with Baricitinib or Adalimumab Plus Methotrexate: Results from the RA-BEAM Trial

(2019) Peter C. Taylor et al.   Journal of Clinical Medicine

VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis

(2018) Nicholas Beazley-Long et al.   BRAIN BEHAVIOR AND IMMUNITY

Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial

(2018) Mark C Genovese et al.   LANCET

Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Gerd R Burmester et al.   LANCET

Residual symptoms and disease burden among patients with rheumatoid arthritis in remission or low disease activity: a systematic literature review

(2018) Masato Ishida et al.   Modern Rheumatology

Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain

(2018) Louise S.C. Nicol et al.   PAIN

Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway

(2018) Fausto Salaffi et al.   Pain Research & Management

General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation

(2018) Mun Yam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms for Joint Pain in Rheumatoid Arthritis (RA): from Cytokines to Central Sensitization

(2018) Angela Zhang et al.   Current Osteoporosis Reports

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

(2017) Peter C. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Individual differences in pain

(2017) Roger B. Fillingim   PAIN

Divergent roles of immune cells and their mediators in pain

(2017) Ramin Raoof et al.   RHEUMATOLOGY

Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis

(2017) Ernest H S Choy et al.   RHEUMATOLOGY

IL-17 induces reactive astrocytes and up-regulation of vascular endothelial growth factor (VEGF) through JAK/STAT signaling

(2017) Tao You et al.   Scientific Reports

Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study

(2016) Maxime Dougados et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain

(2016) Katarzyna Popiolek-Barczyk et al.   CURRENT MEDICINAL CHEMISTRY

Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation

(2016) Adrian Achuthan et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-6: an emerging regulator of pathological pain

(2016) Ya-Qun Zhou et al.   Journal of Neuroinflammation

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia–neuron interaction

(2016) Mayumi Sonekatsu et al.   Molecular Pain

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Non-inflammatory Causes of Pain in Patients with Rheumatoid Arthritis

(2016) Sean D. Boyden et al.   Current Rheumatology Reports

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Patient Expectations and Perceptions of Goal-setting Strategies for Disease Management in Rheumatoid Arthritis

(2015) V. Strand et al.   JOURNAL OF RHEUMATOLOGY

Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

(2015) Larissa G. Pinto et al.   ARTHRITIS RESEARCH & THERAPY

The molecular regulation of Janus kinase (JAK) activation

(2014) Jeffrey J. Babon et al.   BIOCHEMICAL JOURNAL

Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling

(2014) Anna Dellarole et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors

(2014) S. C. Meyer et al.   CLINICAL CANCER RESEARCH

Mechanisms, impact and management of pain in rheumatoid arthritis

(2014) David A. Walsh et al.   Nature Reviews Rheumatology

Nociceptive neurons detect cytokines in arthritis

(2014) Hans-Georg Schaible   ARTHRITIS RESEARCH & THERAPY

Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis

(2013) Joel Kremer et al.   ANNALS OF INTERNAL MEDICINE

Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis

(2013) Jian-Min Sun et al.   DISEASE MARKERS

Chemokine and cytokine levels in osteoarthritis and rheumatoid arthritis synovial fluid

(2013) Ulrike Hampel et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Patient Perceptions concerning Pain Management in the Treatment of Rheumatoid Arthritis

(2013) P Taylor et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

(2013) Gerd R Burmester et al.   LANCET

Back to the future: oral targeted therapy for RA and other autoimmune diseases

(2013) John J. O'Shea et al.   Nature Reviews Rheumatology

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain

(2012) Andrew D Cook et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors

(2012) Anna Yarilina et al.   ARTHRITIS AND RHEUMATISM

Biology and significance of the JAK/STAT signalling pathways

(2012) Hiu Kiu et al.   GROWTH FACTORS

Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia

(2012) Gisela Segond von Banchet et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

JAK-STAT1/3-Induced Expression of Signal Sequence-Encoding Proopiomelanocortin mRNA in Lymphocytes Reduces Inflammatory Pain in Rats

(2012) Melanie Busch-Dienstfertig et al.   Molecular Pain

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

(2012) Ronald F. van Vollenhoven et al.   NEW ENGLAND JOURNAL OF MEDICINE

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

(2011) Sanna Rosengren et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of TNF-alpha during central sensitization in preclinical studies

(2011) Pablo Andrade et al.   NEUROLOGICAL SCIENCES

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-4 Deficiency Is Associated with Mechanical Hypersensitivity in Mice

(2011) Nurcan Üçeyler et al.   PLoS One

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

(2011) Andreas Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines

(2011) Hans-Georg Schaible et al.   ARTHRITIS RESEARCH & THERAPY

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

(2011) Yvonne C Lee et al.   ARTHRITIS RESEARCH & THERAPY

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

Individual Differences in the Subjective Experience of Pain: New Insights Into Mechanisms and Models

(2010) Robert C. Coghill   HEADACHE

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-17 Contributes to Neuroinflammation and Neuropathic Pain Following Peripheral Nerve Injury in Mice

(2010) Cristina Fabiola Kim et al.   JOURNAL OF PAIN

TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: Distinct role of TNF receptor subtypes 1 and 2

(2010) Ling Zhang et al.   PAIN

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Biology of interleukin-22

(2010) Kerstin Wolk et al.   Seminars in Immunopathology

A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain

(2009) M. Andratsch et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

(2009) Matthias Schweizerhof et al.   NATURE MEDICINE

IL-17 mediates articular hypernociception in antigen-induced arthritis in mice

(2009) Larissa G. Pinto et al.   PAIN

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration

(2008) D. Gómez-Nicola et al.   JOURNAL OF NEUROCHEMISTRY

The effects of TNF deficiency on age-related cognitive performance

(2008) J. McAfoose et al.   PSYCHONEUROENDOCRINOLOGY

Association between genetic variants of IL-1β, IL-6 and TNF-α cytokines and cognitive performance in the elderly general population of the MEMO-study

(2007) Bernhard T. Baune et al.   PSYCHONEUROENDOCRINOLOGY