Biology and significance of the JAK/STAT signalling pathways

Dual Role of the Jak1 FERM and Kinase Domains in Cytokine Receptor Binding and in Stimulation-Dependent Jak Activation

(2014) S. Haan et al.   JOURNAL OF IMMUNOLOGY

STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production

(2014) T. Owaki et al.   JOURNAL OF IMMUNOLOGY

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN 

(2011) A. Begitt et al.   BLOOD

Confocal imaging studies cast doubt on nuclear localization of JAK2V617F

(2011) F. Girodon et al.   BLOOD

JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation

(2011) Fan Liu et al.   CANCER CELL

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

Nuclear pore complex—a coat specifically tailored for the nuclear envelope

(2011) Evgeny Onischenko et al.   CURRENT OPINION IN CELL BIOLOGY

Cytokine-induced Paracrystals Prolong the Activity of Signal Transducers and Activators of Transcription (STAT) and Provide a Model for the Regulation of Protein Solubility by Small Ubiquitin-like Modifier (SUMO)

(2011) Mathias Droescher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis

(2011) Animesh Pardanani et al.   JOURNAL OF CLINICAL ONCOLOGY

STAT1 Signaling Is Not Regulated by a Phosphorylation-Acetylation Switch

(2011) F. Antunes et al.   MOLECULAR AND CELLULAR BIOLOGY

Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond

(2011) Alfonso Quintás-Cardama et al.   NATURE REVIEWS DRUG DISCOVERY

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

(2011) Daniela Ungureanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation

(2011) Arturo Sanz et al.   PLoS One

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

(2011) Stuart T. Perry et al.   PLoS Pathogens

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Live Cell Imaging Reveals Continuous STAT6 Nuclear Trafficking

(2010) H.-C. Chen et al.   JOURNAL OF IMMUNOLOGY

The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins

(2010) HyeonJoo Cheon et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer

(2010) Tracy Putoczki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

(2010) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

(2010) Dean S. Griffiths et al.   NATURE CELL BIOLOGY

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

(2010) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement

(2009) Z. Wang et al.   BLOOD

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F Mutant

(2009) Megumi Funakoshi-Tago et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Regulates Transcription Factors STAT-1 and NF- B to Promote Inducible Nitric Oxide Synthase and Inflammatory Responses

(2009) R. Dai et al.   JOURNAL OF IMMUNOLOGY

The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression

(2009) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY

A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors

(2009) T. Kawashima et al.   MOLECULAR AND CELLULAR BIOLOGY

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

Stat1 Nuclear Translocation by Nucleolin upon Monocyte Differentiation

(2009) Uwe Jerke et al.   PLoS One

Unphosphorylated STATs go nuclear

(2008) Stephen Brown et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Role of the proteasome in modulating native G-CSFR expression

(2008) Tamila L. Kindwall-Keller et al.   CYTOKINE