Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway

Patient-reported outcomes from a randomised phase III study of baricitinib in patients with rheumatoid arthritis and an inadequate response to biological agents (RA-BEACON)

(2016) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study

(2016) Maxime Dougados et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of psychological factors in inflammatory rheumatic diseases: From burden to tailored treatment

(2016) Henriët van Middendorp et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The 12-item Psoriatic Arthritis Impact of Disease Questionnaire: Construct Validity, Reliability, and Interpretability in a Clinical Setting

(2016) Marco Di Carlo et al.   JOURNAL OF RHEUMATOLOGY

How to measure chronic pain: New concepts

(2015) Fausto Salaffi et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics

(2015) Jenny Molet et al.   JOURNAL OF NEUROCHEMISTRY

Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca 2+ /CaMKII signaling pathways in the small intestine

(2015) Yan Yang et al.   PHARMACOLOGICAL RESEARCH

The association between chronic pain and obesity

(2015) Akiko Okifuji et al.   Journal of Pain Research

Tofacitinib

(2014) Deepti Vyas et al.   ANNALS OF PHARMACOTHERAPY

Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis

(2014) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Tofacitinib for acute rheumatoid arthritis patients who have had an inadequate response to disease-modifying antirheumatic drug (DMARD): a systematic review and meta-analysis

(2014) Xingming Zhang et al.   CLINICAL RHEUMATOLOGY

Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression

(2014) Yousef Tizabi et al.   MOLECULES

Mechanisms, impact and management of pain in rheumatoid arthritis

(2014) David A. Walsh et al.   Nature Reviews Rheumatology

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disease Activity in Psoriatic Arthritis: Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World

(2014) Fausto Salaffi et al.   Biomed Research International

Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials

(2014) Gwan Gyu Song et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysis

(2013) Eva Salgado et al.   ANNALS OF THE RHEUMATIC DISEASES

Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study

(2013) Désirée van der Heijde et al.   ARTHRITIS AND RHEUMATISM

Chemokine (C–X–C motif) ligand (CXCL)10 in autoimmune diseases

(2013) Alessandro Antonelli et al.   AUTOIMMUNITY REVIEWS

Efficacy, safety and tolerability of tofacitinib in patients with an inadequate response to disease modifying anti-rheumatic drugs: a meta-analysis of randomized double-blind controlled studies

(2013) Asres Berhan   BMC MUSCULOSKELETAL DISORDERS

Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis

(2013) Ying He et al.   BMC MUSCULOSKELETAL DISORDERS

The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis

(2013) Paweł Kawalec et al.   CLINICAL RHEUMATOLOGY

Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model

(2013) Yue Li et al.   International Journal of Medical Sciences

Mu opioid receptor agonist-selective regulation of interleukin-4 in T lymphocytes

(2013) Christine Börner et al.   JOURNAL OF NEUROIMMUNOLOGY

Cytokines and Pain

(2013) Caio Marcio Barros de Oliveira et al.   Revista Brasileira de Anestesiologia

Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis?

(2012) Klaus W Frommer et al.   ANNALS OF THE RHEUMATIC DISEASES

Discrepancies between patients and physicians in their perceptions of rheumatoid arthritis disease activity

(2012) Paul Studenic et al.   ARTHRITIS AND RHEUMATISM

Review: Central pain mechanisms in the rheumatic diseases: Future directions

(2012) Kristine Phillips et al.   ARTHRITIS AND RHEUMATISM

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS

(2012) Martin Giera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pain in Rheumatoid Arthritis

(2012) David A. Walsh et al.   Current Pain and Headache Reports

Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1β-induced thermal hyperalgesic rats

(2012) Chun-Sung Sung et al.   GLIA

Biology and significance of the JAK/STAT signalling pathways

(2012) Hiu Kiu et al.   GROWTH FACTORS

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

(2012) Adrian L Lopresti et al.   JOURNAL OF PSYCHOPHARMACOLOGY

JAK-STAT1/3-Induced Expression of Signal Sequence-Encoding Proopiomelanocortin mRNA in Lymphocytes Reduces Inflammatory Pain in Rats

(2012) Melanie Busch-Dienstfertig et al.   Molecular Pain

Spinal Interleukin-10 Therapy to Treat Peripheral Neuropathic Pain

(2012) Erin D. Milligan et al.   NEUROMODULATION

Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative

(2012) S. L. Whittle et al.   RHEUMATOLOGY

A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone

(2011) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs

(2011) Roy Fleischmann et al.   ARTHRITIS AND RHEUMATISM

Chronic widespread pain in the spectrum of rheumatological diseases

(2011) Fabiola Atzeni et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Clinimetric evaluations of patients with chronic widespread pain

(2011) Fausto Salaffi et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

Efficacy of Antidepressants as Analgesics: A Review

(2011) Pinky Dharmshaktu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pain Thresholds in Rheumatoid Arthritis: The Effect of Tender Point Counts and Disease Duration

(2011) L. C. POLLARD et al.   JOURNAL OF RHEUMATOLOGY

Look Beyond the Disease Activity Score of 28 Joints (DAS28): Tender Points Influence the DAS28 in Patients with Rheumatoid Arthritis

(2011) E. TON et al.   JOURNAL OF RHEUMATOLOGY

Fibromyalgia Criteria and Severity Scales for Clinical and Epidemiological Studies: A Modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia

(2011) F. WOLFE et al.   JOURNAL OF RHEUMATOLOGY

Pain, catastrophizing and depression in the rheumatic diseases

(2011) Robert R. Edwards et al.   Nature Reviews Rheumatology

IL-4 Deficiency Is Associated with Mechanical Hypersensitivity in Mice

(2011) Nurcan Üçeyler et al.   PLoS One

In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration

(2011) F. M. Bareyre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy

(2011) H. L. Wright et al.   RHEUMATOLOGY

Population-Based Normative Values for the Western Ontario and McMaster (WOMAC) Osteoarthritis Index: Part I

(2011) Nicholas Bellamy et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Central Sensitization in Patients with Rheumatoid Arthritis: A Systematic Literature Review

(2011) Mira Meeus et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate

(2011) Yoshiya Tanaka et al.   ARTHRITIS CARE & RESEARCH

Determinants of discordance in patients' and physicians' rating of rheumatoid arthritis disease activity

(2011) Nasim A. Khan et al.   ARTHRITIS CARE & RESEARCH

Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study

(2011) Yvonne C Lee et al.   ARTHRITIS RESEARCH & THERAPY

Synovial fluid β-endorphin level in avascular necrosis, rheumatoid arthritis, and osteoarthritis of the femoral head and knee. A controlled pilot study

(2010) Kálmán Toth et al.   CLINICAL RHEUMATOLOGY

SOCS3-Mediated Blockade of JAK/STAT3 Signaling Pathway Reveals Its Major Contribution to Spinal Cord Neuroinflammation and Mechanical Allodynia after Peripheral Nerve Injury

(2010) E. Dominguez et al.   JOURNAL OF NEUROSCIENCE

Relationship Between Fibromyalgia and Obesity in Pain, Function, Mood, and Sleep

(2010) Akiko Okifuji et al.   JOURNAL OF PAIN

Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial

(2010) Francis KL Chan et al.   LANCET

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Adverse effects of chronic opioid therapy for chronic musculoskeletal pain

(2010) Leslie J. Crofford   Nature Reviews Rheumatology

Fibromyalgic rheumatoid arthritis and disease assessment

(2010) L. C. Pollard et al.   RHEUMATOLOGY

Report of the American College of Rheumatology Pain Management Task Force

(2010)   ARTHRITIS CARE & RESEARCH

The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain

(2010) Ricardo Vallejo et al.   Pain Practice

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

(2009) J H Coombs et al.   ANNALS OF THE RHEUMATIC DISEASES

Obesity and osteoarthritis: Is leptin the link?

(2009) Linda J. Sandell   ARTHRITIS AND RHEUMATISM

Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis

(2009) Aline Ranzolin et al.   ARTHRITIS AND RHEUMATISM

Predicting depression in rheumatoid arthritis: The signal importance of pain extent and fatigue, and comorbidity

(2009) Frederick Wolfe et al.   ARTHRITIS AND RHEUMATISM

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

(2009) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Fibromyalgianess

(2009) Frederick Wolfe   ARTHRITIS AND RHEUMATISM

The Interface of Pain and Mood Disturbances in the Rheumatic Diseases

(2009) Don L. Goldenberg   SEMINARS IN ARTHRITIS AND RHEUMATISM

The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties

(2009) Robert M Bennett et al.   ARTHRITIS RESEARCH & THERAPY

Lower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac

(2008) Loren Laine et al.   GASTROENTEROLOGY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Chronic Pain and Obesity in Elderly People: Results from the Einstein Aging Study

(2008) Lucas H. McCarthy et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Investigation into the neural correlates of emotional augmentation of clinical pain

(2008) Petra Schweinhardt et al.   NEUROIMAGE

The other side of the medal: How chemokines promote analgesia

(2008) H.L. Rittner et al.   NEUROSCIENCE LETTERS

Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): A 6-month, double-blind, placebo-controlled trial with pregabalin

(2008) Leslie J. Crofford et al.   PAIN

Resistin in serum is associated with higher levels of IL-1Ra in post-menopausal women with rheumatoid arthritis

(2008) H. Forsblad d'Elia et al.   RHEUMATOLOGY

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

(2008) M. Wills-Karp et al.   Science Signaling

Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study

(2008) Natacha Courvoisier et al.   ARTHRITIS RESEARCH & THERAPY

IL-1β signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

(2007) Wendy Kleibeuker et al.   BRAIN BEHAVIOR AND IMMUNITY

Patient-centered Applications: Use of Information Technology to Promote Disease Management and Wellness. A White Paper by the AMIA Knowledge in Motion Working Group

(2007) G. Demiris et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION