New approaches to advance the use of genetic toxicology analyses for human health risk assessment

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup

(2015) B. Bhaskar Gollapudi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)

(2015) James T. MacGregor et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk

(2015) James T. MacGregor et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment

(2014) G.E. Johnson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice

(2014) Xuefei Cao et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. III: Sensitivity of human cell types to known genotoxic agents

(2014) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Shape and steepness of toxicological dose–response relationships of continuous endpoints

(2013) Wout Slob et al.   CRITICAL REVIEWS IN TOXICOLOGY

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens

(2013) Lya G. Hernández et al.   PLoS One

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea

(2012) Vasily N. Dobrovolsky et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

(2012) B.B. Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Abstracts of the 35th Annual Meeting of the United Kingdom Environmental Mutagen Society, 16th-18th July 2012 at Swansea University, UK

(2012)   MUTAGENESIS

Can carcinogenic potency be predicted from in vivo genotoxicity data? a meta-analysis of historical data

(2011) Lya G. Hernández et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

In vivo assessment of Pig-a gene mutation-recent developments and assay validation

(2011) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Monitoring humans for somatic mutation in the endogenous pig-a gene using red blood cells

(2011) Vasily N. Dobrovolsky et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Report on stage III Pig-a mutation assays using benzo[a]pyrene

(2011) Javed A. Bhalli et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes

(2011) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

International Pig-a gene mutation assay trial: Evaluation of transferability across 14 laboratories

(2011) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Abstracts of the 34th Annual Meeting of the United Kingdom Environmental Mutagen Society, 29th June - 1st July 2011. Held jointly with the Association for Radiation Research at the University of Nottingham, UK

(2011)   MUTAGENESIS

When pigs fly: Immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis

(2011) Stephen D. Dertinger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Follow-up actions from positive results of in vitro genetic toxicity testing

(2010) Kerry L. Dearfield et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

New and emerging technologies for genetic toxicity testing

(2010) Anthony M. Lynch et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment

(2010) Vasily N. Dobrovolsky et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Abstracts of the 33rd Annual Meeting of the United Kingdom Environmental Mutagen society, 12th-14th July 2010 at the University of Derby, UK

(2010)   MUTAGENESIS

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships

(2010) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Integration of Mutation and Chromosomal Damage Endpoints into 28-Day Repeat Dose Toxicology Studies

(2010) Stephen D. Dertinger et al.   TOXICOLOGICAL SCIENCES

In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU

(2009) Elmar Gocke et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Considerations regarding a permitted daily exposure calculation for ethyl methanesulfonate

(2009) Lutz Müller et al.   TOXICOLOGY LETTERS

In vivo genotoxicity of EMS: Statistical assessment of the dose response curves

(2009) Elmar Gocke et al.   TOXICOLOGY LETTERS

MNT and Muta™Mouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU

(2009) Elmar Gocke et al.   TOXICOLOGY LETTERS

Ethyl methanesulfonate toxicity in Viracept—A comprehensive human risk assessment based on threshold data for genotoxicity

(2009) Lutz Müller et al.   TOXICOLOGY LETTERS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS