Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment

Molecular Dosimetry of Endogenous and Exogenous O6-Methyl-dG and N7-Methyl-G Adducts Following Low Dose [D3]-Methylnitrosourea Exposures in Cultured Human Cells

(2014) Vyom Sharma et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Does increase in DNA repair allow “Tolerance-to-Insult” in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice

(2013) Klaus Becker et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens

(2013) Lya G. Hernández et al.   PLoS One

Influence of DNA Repair on Nonlinear Dose-Responses for Mutation

(2013) Adam D. Thomas et al.   TOXICOLOGICAL SCIENCES

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

(2012) B.B. Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Reproductive toxicants have a threshold of adversity

(2011) Aldert H. Piersma et al.   CRITICAL REVIEWS IN TOXICOLOGY

Use of threshold and mode of action in risk assessment

(2011) Kenny S. Crump   CRITICAL REVIEWS IN TOXICOLOGY

Can carcinogenic potency be predicted from in vivo genotoxicity data? a meta-analysis of historical data

(2011) Lya G. Hernández et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Strategies for the follow-up of positive results in the in vitro genotoxicity assays-An international collaborative initiative

(2010) B. Bhaskar Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Fast stable restricted maximum likelihood and marginal likelihood estimation of semiparametric generalized linear models

(2010) Simon N. Wood   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Potential thresholds for genotoxic effects by micronucleus scoring

(2010) A. Elhajouji et al.   MUTAGENESIS

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships

(2010) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate–Induced Chromosome Damage

(2010) Zoulikha M. Zaïr et al.   TOXICOLOGICAL SCIENCES

Dose–response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU

(2009) Lynn H. Pottenger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Non-linear dose–response of DNA-reactive genotoxins: Recommendations for data analysis

(2009) George E. Johnson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A case for a new paradigm in genetic toxicology testing

(2009) Lynn H. Pottenger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

(2009) Lya G. Hernández et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Genotoxic thresholds, DNA repair, and susceptibility in human populations

(2009) Gareth J.S. Jenkins et al.   TOXICOLOGY

In vivo genotoxicity of EMS: Statistical assessment of the dose response curves

(2009) Elmar Gocke et al.   TOXICOLOGY LETTERS

Mechanistic investigations of low dose exposures to the genotoxic compounds bisphenol-A and rotenone

(2007) George E. Johnson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS