The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

Courage for simplification and imperfection in the 21st century assessment of “Endocrine disruption”

(2016) Daniel Dietrich   ALTEX-Alternatives to Animal Experimentation

In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme

(2014) Richard Judson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

(2014) M. E. Bette Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Dose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop

(2013) Melvin E. Andersen et al.   CRITICAL REVIEWS IN TOXICOLOGY

Shape and steepness of toxicological dose–response relationships of continuous endpoints

(2013) Wout Slob et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

(2013) R. A. Budinsky et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

(2013) Clifford R. Elcombe et al.   CRITICAL REVIEWS IN TOXICOLOGY

A chronic oral reference dose for hexavalent chromium-induced intestinal cancer

(2013) Chad M. Thompson et al.   JOURNAL OF APPLIED TOXICOLOGY

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Urinary Free Bisphenol A and Bisphenol A-Glucuronide Concentrations in Newborns

(2013) Rebecca M. Nachman et al.   JOURNAL OF PEDIATRICS

11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action

(2013) Karen Chapman et al.   PHYSIOLOGICAL REVIEWS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use and validation of HT/HC assays to support 21st century toxicity evaluations

(2013) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

FutureTox: Building the Road for 21st Century Toxicology and Risk Assessment Practices

(2013) J. Craig Rowlands et al.   TOXICOLOGICAL SCIENCES

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium

(2012) C.R. Kirman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ontogeny of Hepatic Glucuronidation; Methods and Results

(2012) Elke H.J. Krekels et al.   CURRENT DRUG METABOLISM

Relationship of Creatinine and Nutrition with Arsenic Metabolism

(2012) Mary V. Gamble et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Concentrations of Bisphenol A and Seven Other Phenols in Pooled Sera from 3–11 Year Old Children: 2001–2002 National Health and Nutrition Examination Survey

(2012) Xiaoyun Ye et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Critical review of dose–response options for F344 rat mammary tumors for acrylamide – Additional insights based on mode of action

(2012) Andrew Maier et al.   FOOD AND CHEMICAL TOXICOLOGY

A review of dietary and non-dietary exposure to bisphenol-A

(2012) Tinne Geens et al.   FOOD AND CHEMICAL TOXICOLOGY

Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project

(2012) Katharine Briggs et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Location and Kinetically Defined Mechanism of Cofactors and Reporter Genes in the Cascade of Steroid-regulated Transactivation

(2012) John A. Blackford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PA1 Protein, a New Competitive Decelerator Acting at More than One Step to Impede Glucocorticoid Receptor-mediated Transactivation

(2012) Zhenhuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mode of Action: Moving toward a More Relevant and Efficient Assessment Paradigm

(2012) Vicki Dellarco et al.   JOURNAL OF NUTRITION

Deducing the Temporal Order of Cofactor Function in Ligand-Regulated Gene Transcription: Theory and Experimental Verification

(2012) Edward J. Dougherty et al.   PLoS One

Acetylcholinesterase inhibition dose–response modeling for chlorpyrifos and chlorpyrifos-oxon

(2012) Richard Reiss et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Preliminary evaluation of the human relevance of respiratory tumors observed in rodents exposed to naphthalene

(2012) Vincent J. Piccirillo et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Regulatory Forum Opinion Piece

(2012) Gio Batta Gori   TOXICOLOGIC PATHOLOGY

A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Paused RNA Polymerase II as a Developmental Checkpoint

(2011) Michael Levine   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A

(2011) J. G. Hengstler et al.   CRITICAL REVIEWS IN TOXICOLOGY

Historical perspective on the use of animal bioassays to predict carcinogenicity: Evolution in design and recognition of utility

(2011) L. A. Beyer et al.   CRITICAL REVIEWS IN TOXICOLOGY

In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma

(2011) J. N. Smith et al.   DRUG METABOLISM AND DISPOSITION

The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver

(2011) S. J. Miyagi et al.   DRUG METABOLISM AND DISPOSITION

UGT1A6 and UGT2B15 Polymorphisms and Acetaminophen Conjugation in Response to a Randomized, Controlled Diet of Select Fruits and Vegetables

(2011) S. L. Navarro et al.   DRUG METABOLISM AND DISPOSITION

The road less traveled: New views of steroid receptor action from the path of dose–response curves

(2011) S. Stoney Simons et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

(2011) Sam John et al.   NATURE GENETICS

Application of a source-to-outcome model for the assessment of health impacts from dietary exposures to insecticide residues

(2011) Paul S. Price et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Development of a source-to-outcome model for dietary exposures to insecticide residues: An example using chlorpyrifos

(2011) Paul M. Hinderliter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The human relevant potency threshold: Reducing uncertainty by human calibration of cumulative risk assessments

(2011) C.J. Borgert et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference

(2011) Hans-Olov Adami et al.   TOXICOLOGICAL SCIENCES

Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans

(2011) Jeffrey W. Fisher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: The hunt goes on

(2010) Lucio G. Costa et al.   BIOCHEMICAL PHARMACOLOGY

Hypothesis-based weight of evidence: A tool for evaluating and communicating uncertainties and inconsistencies in the large body of evidence in proposing a carcinogenic mode of action—naphthalene as an example

(2010) Lorenz R. Rhomberg et al.   CRITICAL REVIEWS IN TOXICOLOGY

Glucocorticoid receptor cofactors as therapeutic targets

(2010) S Stoney Simons Jr   CURRENT OPINION IN PHARMACOLOGY

Differences between Human and Rat Intestinal and Hepatic Bisphenol A Glucuronidation and the Influence of Alamethicin on In Vitro Kinetic Measurements

(2010) C. S. Mazur et al.   DRUG METABOLISM AND DISPOSITION

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Mechanisms of Progesterone Receptor Inhibition of Inflammatory Responses in Cellular Models of Breast Cancer

(2010) Sakiko Kobayashi et al.   MOLECULAR ENDOCRINOLOGY

A theoretical framework for gene induction and experimental comparisons

(2010) K. M. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uterine epithelial estrogen receptor   is dispensable for proliferation but essential for complete biological and biochemical responses

(2010) W. Winuthayanon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of read-across and tiered exposure assessment in risk assessment under REACH – A case study on a phase-in substance

(2010) S.R. Vink et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran

(2010) Robert A. Budinsky et al.   TOXICOLOGICAL SCIENCES

Chemical Carcinogenesis

(2010) S. M. Cohen et al.   TOXICOLOGICAL SCIENCES

Longitudinal changes in PON1 enzymatic activities in Mexican–American mothers and children with different genotypes and haplotypes

(2010) Karen Huen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Relationship between estrogen receptor α location and gene induction reveals the importance of downstream sites and cofactors

(2009) Fabio Parisi et al.   BMC GENOMICS

Cruciferous Vegetable Feeding Alters UGT1A1 Activity: Diet- and Genotype-Dependent Changes in Serum Bilirubin in a Controlled Feeding Trial

(2009) S. L. Navarro et al.   Cancer Prevention Research

Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens

(2009) Alan R. Boobis et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Application of a Key Events Dose-Response Analysis to Nutrients: A Case Study with Vitamin A (Retinol)

(2009) A. Catharine Ross et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Key Events Dose-Response Framework: A Foundation for Examining Variability in Elicitation Thresholds for Food Allergens

(2009) Steve L. Taylor et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Key Events Dose-Response Framework: Its Potential for Application to Foodborne Pathogenic Microorganisms

(2009) Robert L. Buchanan † et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds

(2009) Elizabeth Julien* et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

UGT genomic diversity: beyond gene duplication

(2009) Chantal Guillemette et al.   DRUG METABOLISM REVIEWS

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

(2009) Michael H. Court   DRUG METABOLISM REVIEWS

Paraoxonase status and plasma butyrylcholinesterase activity in chlorpyrifos manufacturing workers

(2009) James W Albers et al.   Journal of Exposure Science and Environmental Epidemiology

Citrus Fruit Intake Is Associated with Lower Serum Bilirubin Concentration among Women with the UGT1A1*28 Polymorphism

(2009) Misty R. Saracino et al.   JOURNAL OF NUTRITION

Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose–response relationships, exemplified for mutagenicity data

(2009) Werner K. Lutz et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Importance of steroid receptor coactivators in the modulation of steroid action on brain and behavior

(2009) Thierry D. Charlier   PSYCHONEUROENDOCRINOLOGY

In Vivo Glucuronidation Activity of Drugs in Neonates: Extensive Interindividual Variability Despite Their Young Age

(2009) Karel Allegaert et al.   THERAPEUTIC DRUG MONITORING

Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects

(2009) Kim Boekelheide et al.   TOXICOLOGICAL SCIENCES

Estimates of Cancer Potency of 2,3,7,8-Tetrachlorodibenzo(p)dioxin Using Linear and Nonlinear Dose-Response Modeling and Toxicokinetics

(2009) Ted Simon et al.   TOXICOLOGICAL SCIENCES

Bisphenol A levels in blood depend on age and exposure

(2009) Hans Mielke et al.   TOXICOLOGY LETTERS

What goes on behind closed doors: physiological versus pharmacological steroid hormone actions

(2008) S. Stoney Simons   BIOESSAYS

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

(2008) M.E. Bette Meek   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Exposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants

(2008) Antonia M. Calafat et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Predicting Plasma Concentrations of Bisphenol A in Children Younger Than 2 Years of Age after Typical Feeding Schedules, using a Physiologically Based Toxicokinetic Model

(2008) Andrea N. Edginton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Hill equation: a review of its capabilities in pharmacological modelling

(2008) Sylvain Goutelle et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Consumption of Wonderful Variety Pomegranate Juice and Extract by Diabetic Patients Increases Paraoxonase 1 Association with High-Density Lipoprotein and Stimulates Its Catalytic Activities

(2008) Wasseem Rock et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cholinesterase inhibition in chlorpyrifos workers: Characterization of biomarkers of exposure and response in relation to urinary TCPy

(2008) David H Garabrant et al.   Journal of Exposure Science and Environmental Epidemiology

Derivation of a Bisphenol a Oral Reference Dose (RfD) and Drinking-Water Equivalent Concentration∗

(2008) Calvin C. Willhite et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Modulation of transcription parameters in glucocorticoid receptor-mediated repression

(2008) Yunguang Sun et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Physiologically based Pharmacokinetic Model for Intravenous and Ingested Dimethylarsinic Acid in Mice

(2008) Marina V. Evans et al.   TOXICOLOGICAL SCIENCES

Thermodynamic basis for expressing dose logarithmically

(2008) W WADDELL   TOXICOLOGY AND APPLIED PHARMACOLOGY

Paraoxonase 1 (PON1) status and substrate hydrolysis

(2008) Rebecca J. Richter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY