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Title
Rescuing the Last-Line Polymyxins: Achievements and Challenges
Authors
Keywords
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Journal
PHARMACOLOGICAL REVIEWS
Volume 73, Issue 2, Pages 679-728
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2021-02-24
DOI
10.1124/pharmrev.120.000020
References
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- Potent Synergy and Sustained Bactericidal Activity of a Vancomycin-Colistin Combination versus Multidrug-Resistant Strains of Acinetobacter baumannii
- (2010) N. C. Gordon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Adaptive Resistance to the "Last Hope" Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory System ParR-ParS
- (2010) L. Fernandez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model
- (2010) J. B. Bulitta et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetic/Pharmacodynamic Investigation of Colistin against Pseudomonas aeruginosa Using an In Vitro Model
- (2010) P. J. Bergen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production
- (2010) J. H. Moffatt et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii
- (2010) Glenn A. Pankuch et al. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas
- (2010) Marylise Duperthuy et al. ENVIRONMENTAL MICROBIOLOGY
- Successful treatment of three children with post-neurosurgical multidrug-resistant Acinetobacter baumannii meningitis
- (2010) H. Özdemir et al. INFECTION
- Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients
- (2010) Robin F. Benus et al. INTENSIVE CARE MEDICINE
- Could nephrotoxicity due to colistin be ameliorated with the use of N-acetylcysteine?
- (2010) Ezgi Ozyilmaz et al. INTENSIVE CARE MEDICINE
- Susceptibility of Klebsiella pneumoniae clinical isolates from 2007 to 2009 to colistin and comparator antibiotics
- (2010) Stephen P. Hawser INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Variability of polymyxin B major components in commercial formulations
- (2010) Jie He et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Susceptibility of Klebsiella spp. to colistin and polymyxin B: results from the SENTRY Antimicrobial Surveillance Program (2006–2009)
- (2010) Helio S. Sader et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Hypersensitivity pneumonitis due to high-dose colistin aerosol therapy
- (2010) K.W. Leong et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Evaluation of susceptibility testing methods for polymyxin
- (2010) Bijayini Behera et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice
- (2010) C. Vingsbo Lundberg et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin
- (2010) M. Vaara et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria
- (2010) P. Rattanaumpawan et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The impact of polymyxin B dosage on in-hospital mortality of patients treated with this antibiotic
- (2010) L. S. Elias et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Colistin susceptibility testing: evaluation of reliability for cystic fibrosis isolates of Pseudomonas aeruginosa and Stenotrophomonas maltophilia
- (2010) Samuel M. Moskowitz et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Polymyxin B versus other antimicrobials for the treatment of Pseudomonas aeruginosa bacteraemia
- (2010) C. H. Kvitko et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- In Vitro Evaluation of Antibiotic Synergy for Polymyxin B-Resistant Carbapenemase-Producing Klebsiella pneumoniae
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- Aerosolized Colistin for the Treatment of Multidrug-resistant Acinetobacter baumannii Pneumonia: Experience in a Tertiary Care Hospital in Northern Taiwan
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- Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides
- (2010) Carmen M. Herrera et al. MOLECULAR MICROBIOLOGY
- Structure–activity studies on novel polymyxin derivatives that carry only three positive charges
- (2010) Martti Vaara et al. PEPTIDES
- A novel combination regimen for the treatment of refractory bacteremia due to multidrug-resistant Pseudomonas aeruginosa in a liver transplant recipient
- (2010) H.-Y. Sun et al. Transplant Infectious Disease
- Successful treatment of multidrug-resistantAcinetobacter baumaniiventriculitis with intravenous and intraventricular colistin
- (2009) N. Dalgic et al. ANNALS OF TROPICAL PAEDIATRICS
- Renal Disposition of Colistin in the Isolated Perfused Rat Kidney
- (2009) Z. Ma et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Brain Penetration of Colistin in Mice Assessed by a Novel High-Performance Liquid Chromatographic Technique
- (2009) L. Jin et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Nonclonal Emergence of Colistin-Resistant Klebsiella pneumoniae Isolates from Blood Samples in South Korea
- (2009) J.-Y. Suh et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Activity of Colistin (Polymyxin E) against 3,480 Isolates of Gram-Negative Bacilli Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007-2008
- (2009) A. Walkty et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Does the Activity of the Combination of Imipenem and Colistin In Vitro Exceed the Problem of Resistance in Metallo- -Lactamase-Producing Klebsiella pneumoniae Isolates?
- (2009) M. Souli et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria
- (2009) D. Plachouras et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity
- (2009) Naoko Katsuma et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Nephrotoxicity Associated with Intravenous Colistin (Colistimethate Sodium) Treatment at a Tertiary Care Medical Center
- (2009) Joshua D. Hartzell et al. CLINICAL INFECTIOUS DISEASES
- Intrathecal colistin for drug-resistant Acinetobacter baumannii central nervous system infection: a case series and systematic review
- (2009) T. Khawcharoenporn et al. CLINICAL MICROBIOLOGY AND INFECTION
- Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a prospective evaluation
- (2009) A. Michalopoulos et al. CLINICAL MICROBIOLOGY AND INFECTION
- Decontamination of the digestive tract and oropharynx: hospital acquired infections after discharge from the intensive care unit
- (2009) Anne Marie G. A. de Smet et al. INTENSIVE CARE MEDICINE
- Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock
- (2009) Dinna N. Cruz et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- In vitro activity of various combinations of antimicrobials against carbapenem-resistant Acinetobacter species in Singapore
- (2009) Tze-Peng Lim et al. JOURNAL OF ANTIBIOTICS
- Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration
- (2009) F. E. A. Ali et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa
- (2009) N. Aoki et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Polymyxin B Identified as an Inhibitor of Alternative NADH Dehydrogenase and Malate: Quinone Oxidoreductase from the Gram-positive Bacterium Mycobacterium smegmatis
- (2009) T. Mogi et al. JOURNAL OF BIOCHEMISTRY
- Structure−Activity Relationships of Polymyxin Antibiotics
- (2009) Tony Velkov et al. JOURNAL OF MEDICINAL CHEMISTRY
- Decontamination of the Digestive Tract and Oropharynx in ICU Patients
- (2009) A.M.G.A. de Smet et al. NEW ENGLAND JOURNAL OF MEDICINE
- An ABC transport system that maintains lipid asymmetry in the Gram-negative outer membrane
- (2009) J. C. Malinverni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Infectious Diseases: Parenteral Polymyxin B Use in Patients with Multidrug-Resistant Gram-Negative Bacteremia and Urinary Tract Infections: A Retrospective Case Series
- (2008) Andrew A Pastewski et al. ANNALS OF PHARMACOTHERAPY
- In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy
- (2008) E. S. Moland et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents
- (2008) M. Vaara et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- An Inner Membrane Dioxygenase that Generates the 2-Hydroxymyristate Moiety ofSalmonellaLipid A†
- (2008) Henry S. Gibbons et al. BIOCHEMISTRY
- Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients
- (2008) Alexandre P. Zavascki et al. CLINICAL INFECTIOUS DISEASES
- Colistin serum concentrations after intravenous administration in critically ill patients with serious multidrug-resistant, gram-negative bacilli infections: A prospective, open-label, uncontrolled study
- (2008) Nikolaos Markou et al. CLINICAL THERAPEUTICS
- Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa
- (2008) Margaret Drehobl et al. CURRENT MEDICAL RESEARCH AND OPINION
- Pandrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii infections: Characteristics and outcome in a series of 28 patients
- (2008) Matthew E. Falagas et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae
- (2008) A. Poudyal et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters: assessment of different treatments
- (2008) A. Rodriguez Guardado et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model
- (2008) P. J. Bergen et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients
- (2008) Helle Krogh Johansen et al. Journal of Cystic Fibrosis
- Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia
- (2008) Alex P. Betrosian et al. JOURNAL OF INFECTION
- Comparison of the Structure and Dynamics of the Antibiotic Peptide Polymyxin B and the Inactive Nonapeptide in Aqueous Trifluoroethanol by NMR Spectroscopy
- (2008) Jeffrey J. Meredith et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Capsule polysaccharide is a bacterial decoy for antimicrobial peptides
- (2008) E. Llobet et al. MICROBIOLOGY-SGM
- Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes
- (2008) Sünje Johanna Pamp et al. MOLECULAR MICROBIOLOGY
- Shifting patterns of inhaled antibiotic use in cystic fibrosis
- (2008) Samuel M. Moskowitz et al. PEDIATRIC PULMONOLOGY
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