Novel derivatives of polymyxins

In VitroActivity of Telavancin in Combination with Colistin versus Gram-Negative Bacterial Pathogens

(2012) Michael Hornsey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improving known classes of antibiotics: an optimistic approach for the future

(2012) Karen Bush   CURRENT OPINION IN PHARMACOLOGY

Fourteen years in resistance

(2012) David M. Livermore   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

(2012) Martti Vaara et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies

(2012) Y. Cai et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens

(2012) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells

(2012) Marie-Paule Mingeot-Leclercq et al.   PEPTIDES

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients

(2011) S. M. Garonzik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Des-Fatty Acyl-Polymyxin B Derivatives with Pseudomonas aeruginosa-Specific Antimicrobial Activity

(2011) Yuki Sato et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Colistin-Resistant, Klebsiella pneumoniae Carbapenemase (KPC)-Producing Klebsiella pneumoniae Belonging to the International Epidemic Clone ST258

(2011) T. Bogdanovich et al.   CLINICAL INFECTIOUS DISEASES

Update on antibacterial and antifungal drugs – can we master the resistance crisis?

(2011) Ursula Theuretzbacher et al.   CURRENT OPINION IN PHARMACOLOGY

Dosing of colistin—back to basic PK/PD

(2011) Phillip J Bergen et al.   CURRENT OPINION IN PHARMACOLOGY

Impact of healthcare-associated acquisition on community-onset Gram-negative bloodstream infection: a population-based study

(2011) M. N. Al-Hasan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Acinetobacter baumannii Resistant to Colistin With Impaired Virulence: A Case Report From France

(2011) J.-M. Rolain et al.   JOURNAL OF INFECTIOUS DISEASES

Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii

(2011) Rafael López-Rojas et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxins and their novel derivatives

(2010) Martti Vaara   CURRENT OPINION IN MICROBIOLOGY

Susceptibility of Klebsiella spp. to colistin and polymyxin B: results from the SENTRY Antimicrobial Surveillance Program (2006–2009)

(2010) Helio S. Sader et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice

(2010) C. Vingsbo Lundberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin

(2010) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Susceptibility Profiles, Molecular Epidemiology, and Detection of KPC-ProducingEscherichia coliIsolates from the New York City Vicinity

(2010) David Landman et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Epidemiology, microbiology and outcomes of healthcare-associated and community-acquired bacteremia: A multicenter cohort study

(2010) Marin H. Kollef et al.   JOURNAL OF INFECTION

Structure–activity studies on novel polymyxin derivatives that carry only three positive charges

(2010) Martti Vaara et al.   PEPTIDES

Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity

(2009) Naoko Katsuma et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Nephrotoxicity of Colistin: New Insight into an Old Antibiotic

(2009) Matthew E. Falagas et al.   CLINICAL INFECTIOUS DISEASES

New approaches in peptide antibiotics

(2009) Martti Vaara   CURRENT OPINION IN PHARMACOLOGY

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

(2009) F. E. A. Ali et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY