Polymyxins: a new hope in combating Gram-negative superbugs?

Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

(2016) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissemination of the mcr-1 colistin resistance gene

(2016) Hattie E Webb et al.   LANCET INFECTIOUS DISEASES

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

(2015) Kade D. Roberts et al.   ACS Infectious Diseases

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

(2014) Tony Velkov et al.   ACS Chemical Biology

Cell- and biomarker-based assays for predicting nephrotoxicity

(2014) Johnny X Huang et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Novel derivatives of polymyxins

(2013) M. Vaara   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

(2013) Thomas V. Magee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overcoming the challenges to developing new antibiotics

(2012) David M Shlaes et al.   CURRENT OPINION IN PHARMACOLOGY

The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

(2012) Martti Vaara et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens

(2012) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phosphoethanolamine Modification of Lipid A in Colistin-Resistant Variants of Acinetobacter baumannii Mediated by the pmrAB Two-Component Regulatory System

(2011) Alejandro Beceiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Adaptive Resistance to the "Last Hope" Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory System ParR-ParS

(2010) L. Fernandez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice

(2010) C. Vingsbo Lundberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin

(2010) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System

(2009) M. D. Adams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nosocomial Outbreak of Infection With Pan–Drug-Resistant Acinetobacter baumannii in a Tertiary Care University Hospital

(2009) Raquel Valencia et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

(2009) F. E. A. Ali et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of a Polymyxin Synthetase Gene Cluster of Paenibacillus polymyxa and Heterologous Expression of the Gene in Bacillus subtilis

(2009) S.-K. Choi et al.   JOURNAL OF BACTERIOLOGY

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxins Revisited

(2008) D. Landman et al.   CLINICAL MICROBIOLOGY REVIEWS

Pandrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii infections: Characteristics and outcome in a series of 28 patients

(2008) Matthew E. Falagas et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS