Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics

Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics

(2019) Martti Vaara   MOLECULES

Antimicrobial Susceptibility of Acinetobacter calcoaceticus–Acinetobacter baumannii Complex and Stenotrophomonas maltophilia Clinical Isolates: Results From the SENTRY Antimicrobial Surveillance Program (1997–2016)

(2019) Ana C Gales et al.   Open Forum Infectious Diseases

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP)

(2019) Brian T. Tsuji et al.   PHARMACOTHERAPY

Needed: Antimicrobial Development

(2019) Edward Cox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Mechanisms of Colistin-Induced Nephrotoxicity

(2019) Zhibo Gai et al.   MOLECULES

Structure-Function Studies of Polymyxin B Lipononapeptides

(2019) Alejandra Gallardo-Godoy et al.   MOLECULES

Urinary bactericidal activity of colistin and azidothymidine combinations against mcr-1 positive colistin-resistant Escherichia coli

(2019) Maria LOOSE et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin

(2018) Martti Vaara   MEDICINAL RESEARCH REVIEWS

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

(2018) Craig R. MacNair et al.   Nature Communications

Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae

(2018) Thea Brennan-Krohn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Developing a new antibiotic for extensively drug-resistant pathogens: the case of plazomicin

(2018) U. Theuretzbacher et al.   CLINICAL MICROBIOLOGY AND INFECTION

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

(2018) Alessandro Cassini et al.   LANCET INFECTIOUS DISEASES

The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii

(2018) Jonathan M. Tyrrell et al.   PEPTIDES

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections

(2017) Pamela Brown et al.   JOURNAL OF ANTIBIOTICS

Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis

(2017) Martti Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Recent advances and perspectives in the design and development of polymyxins

(2017) Francesc Rabanal et al.   NATURAL PRODUCT REPORTS

Structure–activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity

(2017) Martti Vaara et al.   PEPTIDES

Global Prevalence of Colistin- and Carbapenem-Resistant Gram-Negative Organisms: SMART 2015–2016

(2017) Sibylle Lob et al.   Open Forum Infectious Diseases

Emergence and clonal spread of colistin resistance due to multiple mutational mechanisms in carbapenemase-producing Klebsiella pneumoniae in London

(2017) Jonathan A. Otter et al.   Scientific Reports

Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne bla KPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections

(2016) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide

(2015) Helio S. Sader et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

(2015) Xiaoxi Lu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Glycopeptide Antibiotic To Overcome the Intrinsic Resistance of Gram-Negative Bacteria

(2015) Venkateswarlu Yarlagadda et al.   ACS Infectious Diseases

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

(2014) Tony Velkov et al.   ACS Chemical Biology

Uptake of Polymyxin B into Renal Cells

(2014) Kamilia Abdelraouf et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin

(2013) Takahiro Suzuki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Activity of Colistin plus Rifampin against Colistin-Resistant KPC-Producing Klebsiella pneumoniae

(2013) Carlo Tascini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

(2013) Zakuan Z Deris et al.   JOURNAL OF ANTIBIOTICS

Speculative strategies for new antibacterials: all roads should not lead to Rome

(2013) Stuart Shapiro   JOURNAL OF ANTIBIOTICS

Novel derivatives of polymyxins

(2013) M. Vaara   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

(2013) Thomas V. Magee et al.   JOURNAL OF MEDICINAL CHEMISTRY

The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium

(2013) James A. Imlay   NATURE REVIEWS MICROBIOLOGY

Rapid Killing of Acinetobacter baumannii by Polymyxins Is Mediated by a Hydroxyl Radical Death Pathway

(2012) Timothy R. Sampson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09)

(2011) A. C. Gales et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY