Whether short peptides are good candidates for future neuroprotective therapeutics?

PACAP and NAP: Effect of Two Functionally Related Peptides in Diabetic Retinopathy

(2021) Agata Grazia D’Amico et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage

(2021) Haichen Wang et al.   Neurocritical Care

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine

(2020) Alexandre Iarkov et al.   Frontiers in Aging Neuroscience

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

(2020) Bruno P. Meloni et al.   Frontiers in Neurology

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

(2020) Adam Armada-Moreira et al.   Frontiers in Cellular Neuroscience

Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety

(2020) Adam B. Edwards et al.   DRUG SAFETY

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

(2020) Zelin Lai et al.   Cell and Bioscience

Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

(2020) Anna Jakubczyk et al.   Foods

Structural and functional properties of food protein-derived antioxidant peptides

(2019) Ifeanyi D. Nwachukwu et al.   JOURNAL OF FOOD BIOCHEMISTRY

Bioactive food derived peptides: a review on correlation between structure of bioactive peptides and their functional properties

(2019) Zohreh Karami et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

(2019) Jialin Duan et al.   Journal of Neuroinflammation

The Antimicrobial Peptide CopA3 Inhibits Clostridium difficile Toxin A-Induced Viability Loss and Apoptosis in Neural Cells

(2019) I Na Yoon et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Nanoparticles: Oral Delivery for Protein and Peptide Drugs

(2019) Shu-jun Cao et al.   AAPS PHARMSCITECH

Mechanisms of Neuroprotective Effects of Peptides Derived from Natural Materials and Their Production and Assessment

(2019) Seung Yun Lee et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s disease

(2019) Irina Matlahov et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons

(2019) Sandra Cristina Zárate et al.   Frontiers in Aging Neuroscience

Protective effects of distinct proline-rich oligopeptides from B. jararaca snake venom against oxidative stress-induced neurotoxicity

(2019) Samyr Machado Querobino et al.   TOXICON

Natural Products and Neuroprotection

(2019) Cristina Angeloni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Potential of Pituitary Adenylate Cyclase Activating Polypeptide in Retinal Degenerations of Metabolic Origin

(2019) Robert Gábriel et al.   Frontiers in Neuroscience

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

(2019) Antonella Amato et al.   Antioxidants

Poly-Arginine Peptide-18 (R18) Reduces Brain Injury and Improves Functional Outcomes in a Nonhuman Primate Stroke Model

(2019) Bruno P. Meloni et al.   Neurotherapeutics

Neuroprotection Against Hypoxic/Ischemic Injury: δ-Opioid Receptors and BDNF-TrkB Pathway

(2018) Shiying Sheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Huntington's disease: From basic science to therapeutics

(2018) Carlos Cepeda et al.   CNS Neuroscience & Therapeutics

The neuroprotective role of the brain opioid system in stroke injury

(2018) Bhuvaneshwar Vaidya et al.   DRUG DISCOVERY TODAY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

The Role of Immunosenescence in Neurodegenerative Diseases

(2018) Erica Costantini et al.   MEDIATORS OF INFLAMMATION

Bradykinin-potentiating PEPTIDE-10C, an argininosuccinate synthetase activator, protects against H 2 O 2 -induced oxidative stress in SH-SY5Y neuroblastoma cells

(2018) Samyr Machado Querobino et al.   PEPTIDES

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies

(2018) Diego Milani et al.   PLoS One

Cytoprotective effect and purification of novel antioxidant peptides from hazelnut ( C. heterophylla Fisch) protein hydrolysates

(2018) Chunlei Liu et al.   Journal of Functional Foods

Stability of Antiradical Activity of Protein Extracts and Hydrolysates from Dry-Cured Pork Loins with Probiotic Strains of LAB

(2018) Paulina Kęska et al.   Nutrients

Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

(2018) Adam B. Edwards et al.   Molecular Brain

The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson’s Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy

(2018) Bing Wang et al.   Frontiers in Molecular Neuroscience

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Assessment of therapeutic window for poly-arginine-18D (R18D) in a P7 rat model of perinatal hypoxic-ischaemic encephalopathy

(2018) Adam B. Edwards et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury

(2018) Yihao Zhu et al.   Oxidative Medicine and Cellular Longevity

Bioactive peptides as natural antioxidants in food products – A review

(2018) Jose M. Lorenzo et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Neuroprotective agents in Acute Ischemic Stroke—A Reality Check

(2018) Luxitaa Goenka et al.   BIOMEDICINE & PHARMACOTHERAPY

Current drugs and potential future neuroprotective compounds for Parkinson`s disease

(2018) Ivan Carrera et al.   Current Neuropharmacology

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics

(2018) Gabriella MacDougall et al.   NEUROBIOLOGY OF DISEASE

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

(2017) Taiwo Olayemi Elufioye et al.   Evidence-based Complementary and Alternative Medicine

Neuroprotective Effects of Acetylcholinesterase Inhibitory Peptides from Anchovy (Coilia mystus) against Glutamate-Induced Toxicity in PC12 Cells

(2017) Tiantian Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

(2017) Hilmar Bading   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroprotective effects of a novel peptide, FK18, under oxygen-glucose deprivation in SH-SY5Y cells and retinal ischemia in rats via the Akt pathway

(2017) Shuyu Xiong et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

(2017) Diego Milani et al.   NEUROSCIENCE RESEARCH

Neuroprotective property of low molecular weight fraction from B. jararaca snake venom in H 2 O 2 -induced cytotoxicity in cultured hippocampal cells

(2017) Samyr Machado Querobino et al.   TOXICON

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke

(2017) Tian Ming Tu et al.   Annals of Clinical and Translational Neurology

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model

(2017) Daniel T. Laskowitz et al.   Scientific Reports

Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model

(2016) Diego Milani et al.   BMC NEUROSCIENCE

Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review

(2016) Arrigo F G Cicero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects

(2016) Jeffrey T. Guptill et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model

(2016) Ying-Zheng Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Dose-dependent neuroprotection of delta-opioid peptide [D-Ala 2 , D-Leu 5 ] enkephalin on spinal cord ischemia-reperfusion injury by regional perfusion into the abdominal aorta in rabbits

(2016) Haitong Liu et al.   JOURNAL OF VASCULAR SURGERY

The Structure-Activity Relationship of the Antioxidant Peptides from Natural Proteins

(2016) Tang-Bin Zou et al.   MOLECULES

Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation

(2016) Yunjun Zou et al.   NEUROCHEMICAL RESEARCH

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

(2016) Su-Jeong Kim et al.   Oncotarget

Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage

(2016) Beilei Lei et al.   Scientific Reports

In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment

(2015) Li Yang et al.   BRAIN RESEARCH

Therapeutic potential of PACAP for neurodegenerative diseases

(2015) Rongqiang Yang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Novel cell-penetrating peptide targeting mitochondria

(2015) Carmine Pasquale Cerrato et al.   FASEB JOURNAL

Biologically active peptides: Processes for their generation, purification and identification and applications as natural additives in the food and pharmaceutical industries

(2015) Ruann Janser Soares de Castro et al.   FOOD RESEARCH INTERNATIONAL

Inhibition ofN-Methyl-d-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

(2015) John Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models

(2015) Bruno P Meloni et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation

(2015) Qing Xin et al.   PEPTIDES

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

(2015) Bruno P. Meloni et al.   PHARMACOLOGY & THERAPEUTICS

Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains

(2014) Jing Chen et al.   HIPPOCAMPUS

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bioavailability of Endomorphins and the Blood-brain Barrier- A Review

(2014) Renata Perlikowska et al.   Medicinal Chemistry

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

(2014) ZHIYOU CAI   Molecular Medicine Reports

Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity

(2014) Pengcheng Han et al.   NEUROBIOLOGY OF AGING

Humanin Rescues Cultured Rat Cortical Neurons from NMDA-Induced Toxicity Not by NMDA Receptor

(2014) Ai-Ling Cui et al.   TheScientificWorldJOURNAL

Insect peptide CopA3-induced protein degradation of p27Kip1 stimulates proliferation and protects neuronal cells from apoptosis

(2013) Seung Taek Nam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures

(2013) Bruno P. Meloni et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection

(2013) Meaghan Staples et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PACAP Protects Against Salsolinol-Induced Toxicity in Dopaminergic SH-SY5Y Cells: Implication for Parkinson’s Disease

(2013) Dwayne Brown et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

PACAP promotes neuron survival in early experimental diabetic retinopathy

(2013) Krisztina Szabadfi et al.   NEUROCHEMISTRY INTERNATIONAL

Morphine Protects SH-SY5Y Human Neuroblastoma Cells Against 6-Hydroxydopamine–Induced Cell Damage: Involvement of Anti-Oxidant, Calcium Blocking, and Anti-Apoptotic Properties

(2013) Leila Elyasi et al.   REJUVENATION RESEARCH

Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides

(2012) O. Power et al.   AMINO ACIDS

Neuroprotection of apelin and its signaling pathway

(2012) Baohua Cheng et al.   PEPTIDES

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease

(2012) Zhiyin Xun et al.   Cell Reports

Opioid receptor agonists reduce brain edema in stroke

(2011) Li Yang et al.   BRAIN RESEARCH

Neuroprotective Effects of a Novel Peptide Purified from Venison Protein

(2011) Eun-Kyung Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Morphine Protects against Intracellular Amyloid Toxicity by Inducing Estradiol Release and Upregulation of Hsp70

(2011) J. Cui et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Potential of Biphalin, Multireceptor Opioid Peptide, Against Excitotoxic Injury in Hippocampal Organotypic Culture

(2011) Maria Kawalec et al.   NEUROCHEMICAL RESEARCH

Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain

(2011) Narendra K. Sharma et al.   PEPTIDES

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

(2011) Takako Niikura et al.   PLoS One

Apelin Deficiency Accelerates the Progression of Amyotrophic Lateral Sclerosis

(2011) Atsushi Kasai et al.   PLoS One

Development of Opioid Peptide Analogs for Pain Relief

(2010) A. Janecka et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons

(2010) Xiang Jun Zeng et al.   EXPERIMENTAL CELL RESEARCH

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Antioxidative peptides from food proteins: A review

(2010) Bahareh H. Sarmadi et al.   PEPTIDES

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

(2009) Lichuan Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

δ-Opioid receptor activation attenuates oxidative injury in the ischemic rat brain

(2009) Yilin Yang et al.   BMC BIOLOGY

Characteristics of compounds that cross the blood-brain barrier

(2009) William A Banks   BMC Neurology

Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen–glucose deprivation caused neuronal injury through the MAPK pathway

(2009) Sun Ke et al.   BRAIN RESEARCH

Addressing Alzheimers Disease Tangles: From NAP to AL-108

(2009) Illana Gozes et al.   Current Alzheimer Research

Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130

(2009) Yuichi Hashimoto et al.   MOLECULAR BIOLOGY OF THE CELL

NAP prevents hippocampal oxidative damage in neonatal rats subjected to hypoxia-induced seizures

(2009) Samuel Greggio et al.   NEUROBIOLOGY OF DISEASE

Unconjugated TAT Carrier Peptide Protects Against Excitotoxicity

(2009) Anne Vaslin et al.   NEUROTOXICITY RESEARCH

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Protein Misfolding and Neurodegeneration

(2008) Claudio Soto et al.   ARCHIVES OF NEUROLOGY

Delivery of peptides to the brain: Emphasis on therapeutic development

(2008) William A. Banks   BIOPOLYMERS

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endomorphins and morphine limit anoxia–reoxygenation-induced brain mitochondrial dysfunction in the mouse

(2008) Yun Feng et al.   LIFE SCIENCES

Neuroprotective effects of PACAP27 in mice model of Parkinson’s disease involved in the modulation of KATP subunits and D2 receptors in the striatum

(2008) Gang Wang et al.   NEUROPEPTIDES

Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeiana Shaw

(2007) Zhong-Ji Qian et al.   BIORESOURCE TECHNOLOGY

Neuroprotection and functional recovery conferred by administration of kappa- and delta1-opioid agonists in a rat model of global ischemia

(2007) Charlaine Charron et al.   PHYSIOLOGY & BEHAVIOR

Complete Sequence of a Novel Protein Containing a Femtomolar-Activity-Dependent Neuroprotective Peptide

(2003) Merav Bassan et al.   JOURNAL OF NEUROCHEMISTRY