Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety

Nerinetide before reperfusion in acute ischaemic stroke: déjà vu or new insights?

(2020) Graeme J Hankey   LANCET

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

(2020) Michael D Hill et al.   LANCET

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

(2020) Bruno P. Meloni et al.   Frontiers in Neurology

Do We Need Anti-Prion Compounds to Treat Alzheimer’s Disease?

(2019) Dieter Willbold et al.   MOLECULES

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

(2019) Anne Elfgen et al.   Scientific Reports

Toward the Mode of Action of the Clinical Stage All-d-Enantiomeric Peptide RD2 on Aβ42 Aggregation

(2019) Tao Zhang et al.   ACS Chemical Neuroscience

Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat

(2019) Lane Liddle et al.   PLoS One

Poly-Arginine Peptide-18 (R18) Reduces Brain Injury and Improves Functional Outcomes in a Nonhuman Primate Stroke Model

(2019) Bruno P. Meloni et al.   Neurotherapeutics

Anticoagulant and side-effects of protamine in cardiac surgery: a narrative review

(2018) C. Boer et al.   BRITISH JOURNAL OF ANAESTHESIA

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology

(2018) Sarah Schemmert et al.   MOLECULAR NEUROBIOLOGY

Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies

(2018) Diego Milani et al.   PLoS One

Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

(2018) Adam B. Edwards et al.   Molecular Brain

Assessment of therapeutic window for poly-arginine-18D (R18D) in a P7 rat model of perinatal hypoxic-ischaemic encephalopathy

(2018) Adam B. Edwards et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Thrombolysis After Protamine Reversal of Heparin for Acute Ischemic Stroke After Cardiac Catheterization

(2018) Danielle S. Warner et al.   NEUROLOGIST

Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine–Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in Rats

(2017) Bruno P. Meloni et al.   NEUROMOLECULAR MEDICINE

Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

(2017) Diego Milani et al.   NEUROSCIENCE RESEARCH

Alteplase for Acute Ischemic Stroke after Heparin Reversal with Protamine: A Case Report and Review

(2017) Gabriel V. Fontaine et al.   PHARMACOTHERAPY

Peptides with Dual Antimicrobial and Anticancer Activities

(2017) Mário R. Felício et al.   Frontiers in Chemistry

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

(2017) Thomas van Groen et al.   Scientific Reports

Pharmacokinetic properties of tandem d-peptides designed for treatment of Alzheimer's disease

(2016) Leonie H.E. Leithold et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The toxicology of heparin reversal with protamine: past, present and future

(2016) Emilia Sokolowska et al.   Expert Opinion on Drug Metabolism & Toxicology

Human IgE-independent systemic anaphylaxis

(2016) Fred D. Finkelman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects

(2016) Jeffrey T. Guptill et al.   JOURNAL OF CLINICAL PHARMACOLOGY

New synthetic peptide with efficacy for heparin reversal and low toxicity and immunogenicity in comparison to protamine sulfate

(2015) Tong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition ofN-Methyl-d-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

(2015) John Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species

(2015) Lucy M Teves et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Safety and efficacy outcomes of protamine administration for heparin reversal following cryoballoon-based pulmonary vein isolation

(2015) Kadri Murat Gurses et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

(2015) Bruno P. Meloni et al.   PHARMACOLOGY & THERAPEUTICS

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

(2015) Sofie Stalmans et al.   PLoS One

Vessel perforation during withdrawal of Trevo ProVue stent retriever during mechanical thrombectomy for acute ischemic stroke

(2014) Lakshmi Leishangthem et al.   JOURNAL OF NEUROSURGERY

Using Protamine Can Significantly Reduce the Incidence of Bleeding Complications after Carotid Endarterectomy without Increasing the Risk of Ischemic Cerebral Events

(2013) Franco Mazzalai et al.   WORLD JOURNAL OF SURGERY

Physicochemical Characterization of Complex Drug Substances: Evaluation of Structural Similarities and Differences of Protamine Sulfate from Various Sources

(2012) David Awotwe-Otoo et al.   AAPS Journal

Postoperative QT Interval Prolongation in Patients Undergoing Noncardiac Surgery under General Anesthesia

(2012) Peter Nagele et al.   ANESTHESIOLOGY

QTc prolongation is associated with impaired right ventricular function and predicts mortality in pulmonary hypertension

(2012) Jonathan D. Rich et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

Protamine sulfate stimulates degradation of factor Xa and the factor Xa–antithrombin complex

(2011) Martin H Coggin et al.   BLOOD COAGULATION & FIBRINOLYSIS

Neuroprotection by Freezing Ischemic Penumbra Evolution Without Cerebral Blood Flow Augmentation With a Postsynaptic Density-95 Protein Inhibitor

(2011) Bernt T. Bråtane et al.   STROKE

Protamine reduces bleeding complications associated with carotid endarterectomy without increasing the risk of stroke

(2010) David H. Stone et al.   JOURNAL OF VASCULAR SURGERY

The Pharmacokinetics of Cell-Penetrating Peptides

(2010) Dikran Sarko et al.   MOLECULAR PHARMACEUTICS

Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation

(2009) F. Ni Ainle et al.   BLOOD

Cationic amphiphilic peptides with cancer-selective toxicity

(2009) Frank Schweizer   EUROPEAN JOURNAL OF PHARMACOLOGY

Incidence and outcomes of protamine reactions in patients undergoing catheter ablation of atrial fibrillation

(2009) Karuna Chilukuri et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Voltage-Dependent Modulation of Cardiac Ryanodine Receptors (RyR2) by Protamine

(2009) Paula L. Diaz-Sylvester et al.   PLoS One

Serious Anaphylactic Reactions due to Protamine Sulfate: A Systematic Literature Review

(2008) Mads Nybo et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Is Heparin Reversal with Protamine after Carotid Endarterectomy Dangerous?

(2008) D. Dellagrammaticas et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE