Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms

The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

(2020) Maryam Akbari et al.   Lipids in Health and Disease

Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology

(2020) Filip Kosel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

(2020) Caixia Guo et al.   Nutrients

Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain

(2020) Jong Ryeal Hahm et al.   Cells

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women

(2020) Jay Jay Thaung Zaw et al.   Nutrients

Impacts of the late adulthood diet-induced obesity onset on behavior, immune function, redox state and life span of male and female mice

(2019) Caroline Hunsche et al.   BRAIN BEHAVIOR AND IMMUNITY

Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity

(2019) Margherita Springer et al.   Nutrients

Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter

(2019) Iberê Machado Kostrycki et al.   Journal of Diabetes Research

Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health

(2019) Helen M. Melo et al.   Frontiers in Neuroscience

The therapeutic effects of resveratrol on hepatic steatosis in high-fat diet-induced obese mice by improving oxidative stress, inflammation and lipid-related gene transcriptional expression

(2019) Kang Cheng et al.   Medical Molecular Morphology

A metabolic perspective of late onset Alzheimer’s disease

(2019) Miren Ettcheto et al.   PHARMACOLOGICAL RESEARCH

Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer’s Disease Patients

(2019) Cosín-Tomàs et al.   Nutrients

Effect of Aruncus dioicus var. kamtschaticus Extract on Neurodegeneration Improvement: Ameliorating Role in Cognitive Disorder Caused by High-Fat Diet Induced Obesity

(2019) Su Bin Park et al.   Nutrients

Doenjang, A Korean Traditional Fermented Soybean Paste, Ameliorates Neuroinflammation and Neurodegeneration in Mice Fed a High-Fat Diet

(2019) Je Won Ko et al.   Nutrients

Formononetin ameliorates cognitive disorder via PGC-1α pathway in neuroinflammation conditions in high-fat diet-induced mice

(2019) Xinxin Fu et al.   CNS & Neurological Disorders-Drug Targets

Modified Ketogenic Diet Is Associated With Improved Cerebrospinal Fluid Biomarker Profile, Cerebral Perfusion, And Cerebral Ketone Body Uptake In Older Adults At-Risk For Alzheimer’s Disease: A Pilot Study

(2019) Bryan J. Neth et al.   NEUROBIOLOGY OF AGING

The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders

(2019) Breanna L. Zerfas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

(2019) Unger et al.   Nutrients

Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

(2019) Bee Ling Tan et al.   Nutrients

Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study

(2018) Stephen D. Anton et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet

(2018) Miao-miao Zhou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

(2018) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

The retina as a window to early dysfunctions of Alzheimer's disease following studies with a 5xFAD mouse model

(2018) Chiara Criscuolo et al.   NEUROBIOLOGY OF AGING

Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials

(2018) Krzysztof Drygalski et al.   EXPERIMENTAL GERONTOLOGY

Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet

(2018) Narayan R. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease

(2018) David Porquet et al.   JOURNAL OF ALZHEIMERS DISEASE

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model

(2018) Christian Griñán-Ferré et al.   Frontiers in Cellular Neuroscience

Health Effects of Resveratrol: Results from Human Intervention Trials

(2018) Sonia Ramírez-Garza et al.   Nutrients

Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload

(2018) Chen Chen et al.   Redox Biology

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

The protective role of plant biophenols in mechanisms of Alzheimer's disease

(2017) Syed H. Omar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Psychiatric disorders and obesity: A review of association studies

(2017) V Menon et al.   Journal of Postgraduate Medicine

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

(2017) Oriol Busquets et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Distribution of trans -resveratrol and its metabolites after acute or sustained administration in mouse heart, brain, and liver

(2017) Marie-Claude Menet et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Proinsulin protects against age-related cognitive loss through anti-inflammatory convergent pathways

(2017) Rubén Corpas et al.   NEUROPHARMACOLOGY

Metabolic Stress Induces Cognitive Disturbances and Inflammation in Aged Mice: Protective Role of Resveratrol

(2017) Veronica Palomera-Ávalos et al.   REJUVENATION RESEARCH

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Resveratrol and Amyloid-Beta: Mechanistic Insights

(2017) Yongming Jia et al.   Nutrients

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways

(2017) Jeong Yeon Kim et al.   Scientific Reports

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

(2017) Kyong Nyon Nam et al.   Scientific Reports

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

(2016) Christian Griñán-Ferré et al.   Aging-US

The role of dietary fat in obesity-induced insulin resistance

(2016) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity

(2016) C. Griffin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Immunoproteasome in oxidative stress, aging, and disease

(2016) Helen K. Johnston-Carey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease

(2016) Kundlik Gadhave et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

Resveratrol and Alzheimer’s Disease: Mechanistic Insights

(2016) Touqeer Ahmed et al.   MOLECULAR NEUROBIOLOGY

Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway

(2016) V. Palomera-Avalos et al.   MOLECULAR NEUROBIOLOGY

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms

(2016) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus

(2016) R.H.X. Wong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease

(2016) James J. DiNicolantonio et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators

(2016) Emanuela Viggiano et al.   Frontiers in Cellular Neuroscience

High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice

(2016) Peter Thériault et al.   Oncotarget

Resveratrol supplementation: Where are we now and where should we go?

(2015) Marta G. Novelle et al.   AGEING RESEARCH REVIEWS

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption

(2015) E Morselli et al.   INTERNATIONAL JOURNAL OF OBESITY

Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice

(2015) R. E. K. MacPherson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Treadmill running and rutin reverse high fat diet induced cognitive impairment in diet induced obese mice

(2015) J. Cheng et al.   Journal of Nutrition Health & Aging

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Effects of high-fat diet exposure on learning & memory

(2015) Zachary A. Cordner et al.   PHYSIOLOGY & BEHAVIOR

Lifestyle Behaviors in Metabolically Healthy and Unhealthy Overweight and Obese Women: A Preliminary Study

(2015) Sarah M. Camhi et al.   PLoS One

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

(2014) A. V. Witte et al.   JOURNAL OF NEUROSCIENCE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

(2014) Susana Revilla et al.   NEUROPHARMACOLOGY

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Neuroprotective effects of resveratrol in Alzheimer disease pathology

(2014) Shraddha D. Rege et al.   Frontiers in Aging Neuroscience

The ubiquitin proteasome system in glia and its role in neurodegenerative diseases

(2014) Anne H. P. Jansen et al.   Frontiers in Molecular Neuroscience

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

(2013) Marie Orre et al.   BRAIN

Resveratrol: New Avenues for a Natural Compound in Neuroprotection

(2013) Mercè Pallàs et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

(2013) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2013) Masato Maesako et al.   PLoS One

Dietary fat types and 4-year cognitive change in community-dwelling older women

(2012) Olivia I. Okereke et al.   ANNALS OF NEUROLOGY

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

(2012) B. T. Jeon et al.   DIABETES

Protein damage, repair and proteolysis

(2012) Niki Chondrogianni et al.   MOLECULAR ASPECTS OF MEDICINE

Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice

(2011) Soyoung Kim et al.   BIOCHEMICAL PHARMACOLOGY

Immune and non-immune functions of the immunoproteasome

(2011) Arkhjamil Angeles   Frontiers in Bioscience-Landmark

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

(2010) John Gunstad et al.   NEUROEPIDEMIOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One