Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

(2017) Merce Pallas et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells

(2015) Bumsup Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diabetes and Cognition

(2015) Elizabeth Rose Mayeda et al.   CLINICS IN GERIATRIC MEDICINE

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8)

(2015) Christian Griñan-Ferré et al.   MOLECULAR NEUROBIOLOGY

Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice

(2015) Sergi Bayod et al.   NEUROBIOLOGY OF AGING

FDG-PET Contributions to the Pathophysiology of Memory Impairment

(2015) Shailendra Segobin et al.   NEUROPSYCHOLOGY REVIEW

How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario

(2015) Macarena S. Arrázola et al.   Frontiers in Cellular Neuroscience

Complex IV-deficientSurf1−/−mice initiate mitochondrial stress responses

(2014) Daniel A. Pulliam et al.   BIOCHEMICAL JOURNAL

Resveratrol and cancer: focus on in vivo evidence

(2014) Lindsay G Carter et al.   ENDOCRINE-RELATED CANCER

Wnt Inhibitory Factor 1 Deficiency Uncouples Cartilage and Bone Destruction in Tumor Necrosis Factor α-Mediated Experimental Arthritis

(2013) Michael Stock et al.   ARTHRITIS AND RHEUMATISM

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

(2013) A R Hall et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol: New Avenues for a Natural Compound in Neuroprotection

(2013) Mercè Pallàs et al.   CURRENT PHARMACEUTICAL DESIGN

Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis

(2013) Keir J. Menzies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells

(2013) Akihiko Hiyama et al.   ARTHRITIS RESEARCH & THERAPY

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

(2012) David Porquet et al.   AGE

Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

(2012) Antonio Currais et al.   AGING CELL

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease

(2012) John E. Morley et al.   CURRENT PHARMACEUTICAL DESIGN

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

(2012) Nibaldo C. Inestrosa et al.   Journal of Neuroimmune Pharmacology

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

(2011) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence

(2011) Juan Carlos López-Ramos et al.   NEUROBIOLOGY OF AGING

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease

(2010) E M Toledo et al.   MOLECULAR PSYCHIATRY

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Therapeutic potential of resveratrol in Alzheimer's disease

(2008) Valérie Vingtdeux et al.   BMC NEUROSCIENCE

Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: Implications for colon cancer prevention

(2008) Christopher Hope et al.   MOLECULAR NUTRITION & FOOD RESEARCH

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE