Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model

Genetic cartography of longevity in humans and mice: Current landscape and horizons

(2018) Michael Hook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quality of Life in Dementia Sufferers: The Role of Diet and Exercise

(2018) Pasquale Ricci et al.   Current Alzheimer Research

Modulation of Inflammation as a Way of Delaying Alzheimer's Disease Progression: The Diet's Role

(2018) R. Businaro et al.   Current Alzheimer Research

Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model

(2018) Christian Griñán-Ferré et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer’s Disease Mouse Model

(2018) Busra Gurel et al.   JOURNAL OF ALZHEIMERS DISEASE

Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity

(2018) Giuseppe P. Cortese et al.   NEUROBIOLOGY OF AGING

Potential for diet to prevent and remediate cognitive deficits in neurological disorders

(2018) Heather M Francis et al.   NUTRITION REVIEWS

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

(2017) Yang W. Zhang et al.   MOLECULAR CELL

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

(2017) Raúl Delgado-Morales et al.   Clinical Epigenetics

Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain

(2017) Divya Raj et al.   Frontiers in Molecular Neuroscience

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

(2016) Christian Griñán-Ferré et al.   Aging-US

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation

(2016) Kae M. Pusic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor  B-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning

(2016) R. Neidl et al.   JOURNAL OF NEUROSCIENCE

Epigenetics of dementia: understanding the disease as a transformation rather than a state

(2016) Bryan Maloney et al.   LANCET NEUROLOGY

Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats

(2016) Liana R. Stein et al.   NEUROSCIENCE

Can Peripheral MicroRNA Expression Data Serve as Epigenomic (Upstream) Biomarkers of Alzheimer's Disease?

(2016) Şenay Görücü Yılmaz et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease

(2016) Lu Wang et al.   PLoS One

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection

(2016) Christian Griñan-Ferré et al.   Frontiers in Aging Neuroscience

Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV

(2016) S Jha et al.   Translational Psychiatry

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

(2016) M Hüttenrauch et al.   Translational Psychiatry

In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18 F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice

(2015) Bin Liu et al.   JOURNAL OF NEUROSCIENCE

Oxidative Stress Is a Central Target for Physical Exercise Neuroprotection Against Pathological Brain Aging

(2015) Yoelvis García-Mesa et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8)

(2015) Christian Griñan-Ferré et al.   MOLECULAR NEUROBIOLOGY

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease

(2015) Xi Lu et al.   Frontiers in Cellular Neuroscience

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice

(2015) Kyle W. Anderson et al.   FEBS Open Bio

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

(2014) Hasan Irier et al.   GENOMICS

Epigenetics, plasticity, and evolution: How do we link epigenetic change to phenotype?

(2014) Elizabeth J. Duncan et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise

(2014) Marta Cosín-Tomás et al.   Frontiers in Aging Neuroscience

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects

(2013) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

(2013) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models

(2013) B Barak et al.   Translational Psychiatry

Enriched Environment and White Matter in Aging Brain

(2012) Shu Yang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus

(2012) Lauren L. Williamson et al.   BRAIN BEHAVIOR AND IMMUNITY

Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection

(2012) Heidi A. Jurgens et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

(2012) Romain Barrès et al.   Cell Metabolism

Structural Dynamics of Dendritic Spines are Influenced by an Environmental Enrichment: An In Vivo Imaging Study

(2012) Christian K.E. Jung et al.   CEREBRAL CORTEX

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients

(2012) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC1 Regulates Fear Extinction in Mice

(2012) S. Bahari-Javan et al.   JOURNAL OF NEUROSCIENCE

Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat

(2012) Fernanda Cechetti et al.   LIFE SCIENCES

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

(2012) Ana M M Oliveira et al.   NATURE NEUROSCIENCE

Environmental enrichment influences brain cytokine variations elicited by social defeat in mice

(2012) Robyn J. McQuaid et al.   PSYCHONEUROENDOCRINOLOGY

The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

(2012) Adiv A. Johnson et al.   REJUVENATION RESEARCH

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Prolonged Exposure to Particulate Pollution, Genes Associated with Glutathione Pathways, and DNA Methylation in a Cohort of Older Men

(2011) Jaime Madrigano et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

(2011) Latha Devi et al.   NEUROBIOLOGY OF DISEASE

Epigenetic mechanisms in experience-driven memory formation and behavior

(2011) Rosemary E Puckett et al.   Epigenomics

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

(2010) Justin M. Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation

(2010) F. Gomez-Pinilla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Decreased GLT-1 and increased SOD1 and HO-1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1-G93A transgenic mice

(2010) Yansu Guo et al.   FEBS LETTERS

Physiological effects of enriched environment exposure and LTP induction in the hippocampus in vivo do not transfer faithfully to in vitro slices

(2010) M. J. Eckert et al.   LEARNING & MEMORY

DNA methylation and memory formation

(2010) Jeremy J Day et al.   NATURE NEUROSCIENCE

Epigenetic regulation in the pathophysiology of Alzheimer's disease

(2010) Leonidas Chouliaras et al.   PROGRESS IN NEUROBIOLOGY

Reduction of Cerebral Oxidative Stress Following Environmental Enrichment in Mice with Alzheimer-Like Pathology

(2009) Arne Herring et al.   BRAIN PATHOLOGY

Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment

(2009) Francesco Angelucci et al.   CEREBELLUM

Genetic reductions of β-site amyloid precursor protein-cleaving enzyme 1 and amyloid-β ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer’s disease model mice

(2009) Latha Devi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation

(2009) Leah K. Hutnick et al.   HUMAN MOLECULAR GENETICS