Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitro and in Vivo

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

(2020) Greta Bagnolini et al.   JOURNAL OF MEDICINAL CHEMISTRY

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

(2020) Martin Andrs et al.   Genes

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

(2019) Qi-Kun Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

(2019) Alanna R. Kaplan et al.   Science Translational Medicine

Evidence to date: talazoparib in the treatment of breast cancer

(2019) Pedro Exman et al.   OncoTargets and Therapy

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction

(2019) Qian Wang et al.   ORGANIC LETTERS

Salinomycin reduces growth, proliferation and metastasis of cisplatin resistant breast cancer cells via NF-kB deregulation

(2019) Mrityunjay Tyagi et al.   TOXICOLOGY IN VITRO

Emerging therapeutic modalities of PARP inhibitors in breast cancer

(2018) Xin Wang et al.   CANCER TREATMENT REVIEWS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of Cediranib in ovarian cancer

(2017) Cecilia Orbegoso et al.   EXPERT OPINION ON PHARMACOTHERAPY

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

(2017) Joseph A. Newman et al.   NUCLEIC ACIDS RESEARCH

trans-4,4’-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines

(2017) Bhaskar Saha et al.   Oncotarget

Synthesis and evaluation of selected 1,3,4-oxadiazole derivatives for in vitro cytotoxicity and in vivo anti-tumor activity

(2016) Amit Tiwari et al.   CYTOTECHNOLOGY

Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers

(2015) Arvind Arora et al.   CARCINOGENESIS

Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population

(2015) Y.Z. Dong et al.   GENETICS AND MOLECULAR RESEARCH

Regulators of homologous recombination repair as novel targets for cancer treatment

(2015) MaÅ‚gorzata Krajewska et al.   Frontiers in Genetics

Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents

(2014) Yoshifumi Hosono et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe

(2014) S. Sarbajna et al.   GENES & DEVELOPMENT

Association between RECQL5 genetic polymorphisms and susceptibility to breast cancer

(2014) Yu-Jun He et al.   TUMOR BIOLOGY

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

(2013) Giang Huong Nguyen et al.   CHEMISTRY & BIOLOGY

Human RECQL5: Guarding the crossroads of DNA replication and transcription and providing backup capability

(2013) Venkateswarlu Popuri et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing

(2013) Shreya Paliwal et al.   NUCLEIC ACIDS RESEARCH

Haplotype analysis of RECQL5 gene and laryngeal cancer

(2013) Ying Qi et al.   TUMOR BIOLOGY

Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population

(2013) Li-Qiang Zhi et al.   TUMOR BIOLOGY

A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization

(2012) M. Nurul Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma

(2012) Oluf Dimitri Røe et al.   PLoS One

WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes

(2011) B. S. Patro et al.   JOURNAL OF CELL SCIENCE

Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis

(2011) Mohammad H Forouzanfar et al.   LANCET

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

(2011) M. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homologous recombination in cancer development, treatment and development of drug resistance

(2010) T. Helleday   CARCINOGENESIS

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity

(2010) Sybille Schwendener et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RecQL5 Promotes Genome Stabilization through Two Parallel Mechanisms--Interacting with RNA Polymerase II and Acting as a Helicase

(2010) M. N. Islam et al.   MOLECULAR AND CELLULAR BIOLOGY

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT