Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitro and in Vivo
出版年份 2021 全文链接
标题
Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitro and in Vivo
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 3, Pages 1524-1544
出版商
American Chemical Society (ACS)
发表日期
2021-02-05
DOI
10.1021/acs.jmedchem.0c01692
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
- (2020) Greta Bagnolini et al. JOURNAL OF MEDICINAL CHEMISTRY
- RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
- (2020) Martin Andrs et al. Genes
- Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair
- (2019) Qi-Kun Yin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Breast Cancer Treatment
- (2019) Adrienne G. Waks et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51
- (2019) Alanna R. Kaplan et al. Science Translational Medicine
- Evidence to date: talazoparib in the treatment of breast cancer
- (2019) Pedro Exman et al. OncoTargets and Therapy
- 1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction
- (2019) Qian Wang et al. ORGANIC LETTERS
- Salinomycin reduces growth, proliferation and metastasis of cisplatin resistant breast cancer cells via NF-kB deregulation
- (2019) Mrityunjay Tyagi et al. TOXICOLOGY IN VITRO
- Emerging therapeutic modalities of PARP inhibitors in breast cancer
- (2018) Xin Wang et al. CANCER TREATMENT REVIEWS
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The role of Cediranib in ovarian cancer
- (2017) Cecilia Orbegoso et al. EXPERT OPINION ON PHARMACOTHERAPY
- Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
- (2017) Joseph A. Newman et al. NUCLEIC ACIDS RESEARCH
- trans-4,4’-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines
- (2017) Bhaskar Saha et al. Oncotarget
- Synthesis and evaluation of selected 1,3,4-oxadiazole derivatives for in vitro cytotoxicity and in vivo anti-tumor activity
- (2016) Amit Tiwari et al. CYTOTECHNOLOGY
- Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers
- (2015) Arvind Arora et al. CARCINOGENESIS
- Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population
- (2015) Y.Z. Dong et al. GENETICS AND MOLECULAR RESEARCH
- Regulators of homologous recombination repair as novel targets for cancer treatment
- (2015) Małgorzata Krajewska et al. Frontiers in Genetics
- Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents
- (2014) Yoshifumi Hosono et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe
- (2014) S. Sarbajna et al. GENES & DEVELOPMENT
- Association between RECQL5 genetic polymorphisms and susceptibility to breast cancer
- (2014) Yu-Jun He et al. TUMOR BIOLOGY
- A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
- (2013) Giang Huong Nguyen et al. CHEMISTRY & BIOLOGY
- Human RECQL5: Guarding the crossroads of DNA replication and transcription and providing backup capability
- (2013) Venkateswarlu Popuri et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
- (2013) Shreya Paliwal et al. NUCLEIC ACIDS RESEARCH
- Haplotype analysis of RECQL5 gene and laryngeal cancer
- (2013) Ying Qi et al. TUMOR BIOLOGY
- Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population
- (2013) Li-Qiang Zhi et al. TUMOR BIOLOGY
- A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization
- (2012) M. Nurul Islam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma
- (2012) Oluf Dimitri Røe et al. PLoS One
- WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes
- (2011) B. S. Patro et al. JOURNAL OF CELL SCIENCE
- Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis
- (2011) Mohammad H Forouzanfar et al. LANCET
- Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
- (2011) M. Aggarwal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Homologous recombination in cancer development, treatment and development of drug resistance
- (2010) T. Helleday CARCINOGENESIS
- Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity
- (2010) Sybille Schwendener et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RecQL5 Promotes Genome Stabilization through Two Parallel Mechanisms--Interacting with RNA Polymerase II and Acting as a Helicase
- (2010) M. N. Islam et al. MOLECULAR AND CELLULAR BIOLOGY
- An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
- (2009) Balazs Györffy et al. BREAST CANCER RESEARCH AND TREATMENT
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