Connective Tissue and Fibroblast Senescence in Skin Aging

Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing

(2020) Vera Vorstandlechner et al.   FASEB JOURNAL

Origin and functional heterogeneity of fibroblasts

(2020) Valerie S. LeBleu et al.   FASEB JOURNAL

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Biomarkers, oxidative stress and autophagy in skin aging

(2020) Yanpei Gu et al.   AGEING RESEARCH REVIEWS

First evidence that senolytics are effective at decreasing senescent cells in humans

(2020) Georgina M. Ellison-Hughes   EBioMedicine

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

(2020) Llorenç Solé-Boldo et al.   Communications Biology

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

(2020) Alexander Fedintsev et al.   AGEING RESEARCH REVIEWS

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake

(2019) Christian Hausmann et al.   Scientific Reports

Diversity of dermal fibroblasts as major determinant of variability in cell reprogramming

(2019) Anna Maria Sacco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Newly Defined ATP-binding cassette subfamily B member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist

(2019) Seppe Vander Beken et al.   STEM CELLS

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

The chemistry of senescence

(2019) Beatriz Lozano-Torres et al.   Nature Reviews Chemistry

Autophagic Control of Skin Aging

(2019) Leopold Eckhart et al.   Frontiers in Cell and Developmental Biology

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

DNA damage responses in ageing

(2019) Paulo F. L. da Silva et al.   Open Biology

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

(2019) Christina Lee Chung et al.   GeroScience

Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

(2019) Camilla S. L. Tuttle et al.   AGING CELL

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

(2018) Lucia Terlecki-Zaniewicz et al.   Aging-US

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

(2018) Paul Hiebert et al.   DEVELOPMENTAL CELL

Fibroblast heterogeneity: implications for human disease

(2018) Magnus D. Lynch et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Regulation of ATP utilization during metastatic cell migration by collagen architecture

(2018) Matthew R. Zanotelli et al.   MOLECULAR BIOLOGY OF THE CELL

Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

(2018) Dongsheng Jiang et al.   NATURE CELL BIOLOGY

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

(2018) Jodie Birch et al.   PHARMACOLOGY & THERAPEUTICS

Endocytosis as a stabilizing mechanism for tissue homeostasis

(2018) Miri Adler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Hierarchy – An Updated Roadmap

(2018) Yifan Zhang et al.   TRENDS IN CELL BIOLOGY

Matrix stiffness regulates vascular integrity through focal adhesion kinase activity

(2018) Wenjun Wang et al.   FASEB JOURNAL

Lineage identity and location within the dermis determine the function of papillary and reticular fibroblasts in human skin

(2018) Ana Korosec et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biomarkers of Cellular Senescence and Skin Aging

(2018) Audrey S. Wang et al.   Frontiers in Genetics

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo

(2018) Edward Marsh et al.   CELL

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

UVA-1 exposure in vivo leads to an IL-6 surge within the skin

(2017) Lars Alexander Schneider et al.   EXPERIMENTAL DERMATOLOGY

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

(2017) Eleni Mavrogonatou et al.   MATRIX BIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence

(2017) Patrick Meyer et al.   PLoS Computational Biology

The Emerging Facets of Non-Cancerous Warburg Effect

(2017) Alyaa M. Abdel-Haleem et al.   Frontiers in Endocrinology

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

(2016) Eleni Liakou et al.   Aging-US

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype

(2016) Nicolas Malaquin et al.   EXPERIMENTAL GERONTOLOGY

Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review

(2016) Michael C. Velarde et al.   GERONTOLOGY

Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

(2016) Chunya Ni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

What Lies Beneath: Wnt/β-Catenin Signaling and Cell Fate in the Lower Dermis

(2016) Colin A.B. Jahoda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

(2016) Kanad Ghosh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration

(2016) Vida Farsam et al.   Oncotarget

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

(2016) Daniel M. Waldera-Lupa et al.   Aging-US

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

(2015) Daniel M. Waldera Lupa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

(2015) Marco Demaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

(2015) Mariëtte E. C. Waaijer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nanotubes mediate niche–stem-cell signalling in the Drosophila testis

(2015) Mayu Inaba et al.   NATURE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Understanding fibroblast heterogeneity in the skin

(2015) Ryan R. Driskell et al.   TRENDS IN CELL BIOLOGY

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN

(2014) K. Singh et al.   EMBO Molecular Medicine

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer

(2013) Vladimir N. Anisimov et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Secretion of microvesicular miRNAs in cellular and organismal aging

(2012) Sylvia Weilner et al.   EXPERIMENTAL GERONTOLOGY

Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo

(2012) Taihao Quan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Association between Serum Interleukin-6 Concentrations and Mortality in Older Adults: The Rancho Bernardo Study

(2012) Jeffrey K. Lee et al.   PLoS One

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

(2011) Oh Yoen Kim et al.   AGE

Is Growth Hormone Resistance/IGF-1 Reduction Good for You?

(2011) Emily Jane Gallagher et al.   Cell Metabolism

Chronic low-grade inflammation and age-related sarcopenia

(2011) Ingo Beyer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix

(2011) Yun Sun et al.   FASEB JOURNAL

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

(2010) Nicolai Treiber et al.   AGING CELL

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

(2010) Hae Ri Choi et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Protein Pool Maintenance During Oxidative Stress

(2009) B. Catalgol et al.   CURRENT PHARMACEUTICAL DESIGN

Role of Mitochondria in Photoaging of Human Skin: The Defective Powerhouse Model

(2009) Jean Krutmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

(2008) Gary J. Fisher et al.   AMERICAN JOURNAL OF PATHOLOGY