Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing

Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the ‘tissue skeleton’ gene network as a component of skin chrono-ageing

(2019) Valérie Haydont et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling

(2019) Jun Li et al.   EBioMedicine

AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p

(2019) Glenn S. Gerhard et al.   PLoS One

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis

(2018) T Heinosalo et al.   HUMAN REPRODUCTION

SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

(2018) Tracy Tabib et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PDGF in organ fibrosis

(2018) Barbara Mara Klinkhammer et al.   MOLECULAR ASPECTS OF MEDICINE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Lineage identity and location within the dermis determine the function of papillary and reticular fibroblasts in human skin

(2018) Ana Korosec et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human Dermal Fibroblast Subpopulations Display Distinct Gene Signatures Related to Cell Behaviors and Matrisome

(2017) Pauline Nauroy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dipeptidyl peptidase 4 inhibitor attenuates obesity-induced myocardial fibrosis by inhibiting transforming growth factor-βl and Smad2/3 pathways in high-fat diet-induced obesity rat model

(2017) Seul-Ki Hong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Renoprotective effects of a dipeptidyl peptidase 4 inhibitor in a mouse model of progressive renal fibrosis

(2017) Takahiro Uchida et al.   RENAL FAILURE

The glucoregulatory actions of leptin

(2017) Anna M. D'souza et al.   Molecular Metabolism

Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells

(2016) M. Gschwandtner et al.   ALLERGY

Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system

(2016) C. Klemann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability

(2016) Chihiro Hiraoka et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment

(2016) Y Sun et al.   ONCOGENE

Dipeptidyl Peptidase-4, Wound Healing, Scarring, and Fibrosis

(2016) Michael S. Hu et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

(2015) Gopu Sriram et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

(2015) Florian Buettner et al.   NATURE BIOTECHNOLOGY

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Live Fibroblast Harvest Reveals Surface Marker ShiftIn Vitro

(2015) Graham G. Walmsley et al.   TISSUE ENGINEERING PART C-METHODS

Understanding fibroblast heterogeneity in the skin

(2015) Ryan R. Driskell et al.   TRENDS IN CELL BIOLOGY

Leptin and its receptors

(2014) Nobuhiro Wada et al.   JOURNAL OF CHEMICAL NEUROANATOMY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells

(2014) Feng-Juan Lv et al.   STEM CELLS

Cytoscape App Store

(2013) S. Lotia et al.   BIOINFORMATICS

Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats

(2013) Kosuke Kaji et al.   JOURNAL OF GASTROENTEROLOGY

Differential expression of dipeptidyl peptidase IV in human versus cynomolgus monkey skin eccrine sweat glands

(2013) Serafino Pantano et al.   JOURNAL OF MOLECULAR HISTOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

(2012) M. Gschwandtner et al.   ALLERGY

Papillary fibroblasts differentiate into reticular fibroblasts after prolongedin vitroculture

(2012) David Janson et al.   EXPERIMENTAL DERMATOLOGY

Different Gene Expression Patterns in Human Papillary and Reticular Fibroblasts

(2012) David G. Janson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Comparative proteomic analysis between normal skin and keloid scar

(2010) C.T. Ong et al.   BRITISH JOURNAL OF DERMATOLOGY

Markers Distinguishing Mesenchymal Stem Cells from Fibroblasts Are Downregulated with Passaging

(2010) Svetlana Halfon et al.   STEM CELLS AND DEVELOPMENT

Relation between replicative senescence of human fibroblasts and life history characteristics

(2009) Andrea B. Maier et al.   AGEING RESEARCH REVIEWS

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

CD90 Expression on human primary cells and elimination of contaminating fibroblasts from cell cultures

(2009) Lynn Kisselbach et al.   CYTOTECHNOLOGY

CD26/dipeptidyl-peptidase IV in psoriatic skin: upregulation and topographical changes

(2008) R.G. van Lingen et al.   BRITISH JOURNAL OF DERMATOLOGY

The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases

(2007) Anja Thielitz   Frontiers in Bioscience-Landmark

Inhibitors of Dipeptidyl Peptidase IV-Like Activity Mediate Antifibrotic Effects in Normal and Keloid-Derived Skin Fibroblasts

(2007) Anja Thielitz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY