Pulmonary siRNA delivery for lung disease: Review of recent progress and challenges

Poly(lactic-co-glycolic) Acid–Lipid Hybrid Microparticles Enhance the Intracellular Uptake and Antibacterial Activity of Rifampicin

(2020) Sajedeh Maghrebi et al.   ACS Applied Materials & Interfaces

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

(2020) Francesca Mastrotto et al.   MOLECULAR PHARMACEUTICS

Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury

(2020) Chenglong Ge et al.   NANO LETTERS

Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease

(2020) Dan Mei et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lessons from SARS and MERS remind us of the possible therapeutic effects of implementing a siRNA strategy to target COVID‐19: Shoot the messenger!

(2020) Solomon Habtemariam et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Choosing the right inhaler for your asthma or COPD patient

(2019) Omar S Usmani   Therapeutics and Clinical Risk Management

Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases

(2019) Scott K. Ferguson et al.   DRUG DELIVERY

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

(2019) Meenu Mehta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Spray freeze drying: Emerging applications in drug delivery

(2019) D.A. Vishali et al.   JOURNAL OF CONTROLLED RELEASE

Establishment of an Evaluation Method for Gene Silencing by Serial Pulmonary Administration of siRNA and pDNA Powders: Naked siRNA Inhalation Powder Suppresses Luciferase Gene Expression in the Lung

(2019) Takaaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

siRNA therapeutics: a clinical reality

(2019) Phei Er Saw et al.   Science China-Life Sciences

Current Development of siRNA Bioconjugates: From Research to the Clinic

(2019) Ivan V. Chernikov et al.   Frontiers in Pharmacology

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

(2019) Kamal Dua et al.   DRUG DEVELOPMENT RESEARCH

Effect of thermal and shear stresses in the spray drying process on the stability of siRNA dry powders

(2019) Jingya Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mucopenetrating lipoplexes modified with PEG and hyaluronic acid for CD44-targeted local siRNA delivery to the lungs

(2019) Ana Paula Bernardes Almeida et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions

(2019) Zhaoting Li et al.   MOLECULAR THERAPY

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

(2019) Cypriane Dormenval et al.   PHARMACEUTICAL RESEARCH

Editorial: Alveolar Macrophages in Lung Inflammation and Resolution

(2019) Guochang Hu et al.   Frontiers in Immunology

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

(2019) Tobias W.M. Keil et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes

(2019) Yixin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy

(2019) Yuan He et al.   JOURNAL OF CONTROLLED RELEASE

Lipid-based nanocarriers for delivery of small interfering RNA for therapeutic use

(2019) Deepti Parashar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

siRNA Conjugated Nanoparticles—A Next Generation Strategy to Treat Lung Cancer

(2019) Rasha Itani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High siRNA loading powder for inhalation prepared by co-spray drying with human serum albumin

(2019) Michael Y.T. Chow et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted Delivery of siRNA Therapeutics Using Ligand Mediated Biodegradable Polymeric Nanocarriers

(2018) Hong Seo Jin et al.   CURRENT PHARMACEUTICAL DESIGN

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA

(2018) Victoria Capel et al.   DRUG DELIVERY

Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells

(2018) Marta Martínez-Calle et al.   FASEB JOURNAL

Cholesterol-grafted chitosan micelles as a nanocarrier system for drug-siRNA co-delivery to the lung cancer cells

(2018) Omkara Swami Muddineti et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier

(2018) Ivana d'Angelo et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy

(2018) Gizem Osman et al.   JOURNAL OF CONTROLLED RELEASE

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

(2018) Daniel P. Feldmann et al.   JOURNAL OF CONTROLLED RELEASE

Development of spray-freeze-dried siRNA/PEI powder for inhalation with high aerosol performance and strong pulmonary gene silencing activity

(2018) Tomoyuki Okuda et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of LOX-1 siRNA and statin to endothelial cells and macrophages in the atherosclerotic lesions by a dual-targeting core-shell nanoplatform: A dual cell therapy to regress plaques

(2018) Yi Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation

(2018) Heedoo Lee et al.   JOURNAL OF IMMUNOLOGY

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

(2018) Jasmine Viger-Gravel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses

(2018) Duo Zhang et al.   MOLECULAR THERAPY

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

(2018) Aristides D Tagalakis et al.   THORAX

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

(2018) Do-Hyun Kim et al.   Nature Communications

Journey of siRNA: Clinical Developments and Targeted Delivery

(2018) Rahul R. Nikam et al.   Nucleic Acid Therapeutics

Local Intratracheal Delivery of Perfluorocarbon Nanoparticles to Lung Cancer Demonstrated with Magnetic Resonance Multimodal Imaging

(2018) Lina Wu et al.   Theranostics

Intratracheal administration of siRNA dry powder targeting vascular endothelial growth factor inhibits lung tumor growth in mice

(2018) Kei Miwata et al.   Molecular Therapy-Nucleic Acids

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

(2018) Pieterjan Merckx et al.   Acta Biomaterialia

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology

(2018) Pei-Yao Xu et al.   International Journal of Nanomedicine

Cholesterol Modification Enhances Antimetastatic Activity and siRNA Delivery Efficacy of Poly(ethylenimine)-Based CXCR4 Antagonists

(2018) Pengkai Wu et al.   MACROMOLECULAR BIOSCIENCE

Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

(2018) Mikhail Durymanov et al.   Frontiers in Pharmacology

Nucleic Acid-Based Therapeutics for Pulmonary Diseases

(2018) Jing Chen et al.   AAPS PHARMSCITECH

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

(2018) Roberta Guagliardo et al.   JOURNAL OF CONTROLLED RELEASE

Gene silencing of receptor-interacting protein 2 protects against cigarette smoke-induced acute lung injury

(2018) Jinrui Dong et al.   PHARMACOLOGICAL RESEARCH

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

(2017) Marius Hittinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

(2017) Monica Agnoletti et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes

(2017) Mitsuo Otsuka et al.   EXPERIMENTAL LUNG RESEARCH

A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA

(2017) M Choi et al.   GENE THERAPY

Inhaled powder formulation of naked siRNA using spray drying technology with l -leucine as dispersion enhancer

(2017) Michael Y.T. Chow et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations

(2017) Elizabeth Bielski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of silica nanoparticle surface chemistry on protein corona formation and consequential interactions with biological cells

(2017) Andréa Kurtz-Chalot et al.   Materials Science & Engineering C-Materials for Biological Applications

From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery

(2017) Yingshan Qiu et al.   MOLECULAR PHARMACEUTICS

Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation

(2017) Annika Frede et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effects of engineered nanoparticles on the innate immune system

(2017) Yuanchang Liu et al.   SEMINARS IN IMMUNOLOGY

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

(2017) Ivan V. Chernikov et al.   Molecular Therapy-Nucleic Acids

Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

(2017) Maria D. I. Manunta et al.   Scientific Reports

Inhalation Properties and Stability of Nebulized Naked siRNA Solution for Pulmonary Therapy

(2016) Kohei Tahara et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Large Porous Hollow Particles: Lightweight Champions of Pulmonary Drug Delivery

(2016) Sachin Gharse et al.   CURRENT PHARMACEUTICAL DESIGN

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems

(2016) Ying Jiang et al.   Expert Opinion on Drug Delivery

Exosomes from iPSCs Delivering siRNA Attenuate Intracellular Adhesion Molecule-1 Expression and Neutrophils Adhesion in Pulmonary Microvascular Endothelial Cells

(2016) Zhihai Ju et al.   INFLAMMATION

Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis

(2016) Pyoung Oh Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary administration of small interfering RNA: The route to go?

(2016) M.J.R. Ruigrok et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

(2016) Yuran Xie et al.   JOURNAL OF CONTROLLED RELEASE

Barriers to inhaled gene therapy of obstructive lung diseases: A review

(2016) Namho Kim et al.   JOURNAL OF CONTROLLED RELEASE

ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients

(2016) Jens Gottlieb et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis

(2016) Yu Mi et al.   Advanced Healthcare Materials

Perfluorocarbon-Encapsulated PLGA-PEG Emulsions as Enhancement Agents for Highly Efficient Reoxygenation to Cell and Organism

(2015) Yanjie Yao et al.   ACS Applied Materials & Interfaces

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

(2015) Yuran Xie et al.   ARCHIV DER PHARMAZIE

Cholesterol Modified Self-Assemblies and Their Application to Nanomedicine

(2015) Francesca Ercole et al.   BIOMACROMOLECULES

Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response

(2015) Xiawei Wei et al.   CELL RESEARCH

Polyethyleneimine-Based Nanocarriers for Gene Delivery

(2015) Xia Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Dry Powder Formulation of Plasmid DNA and siRNA for Inhalation

(2015) Michael Chow et al.   CURRENT PHARMACEUTICAL DESIGN

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

Bio-inspired materials in drug delivery: Exploring the role of pulmonary surfactant in siRNA inhalation therapy

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

Bio-inspired pulmonary surfactant-modified nanogels: A promising siRNA delivery system

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung

(2015) Matthew S. Twigg et al.   MEDIATORS OF INFLAMMATION

Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus

(2015) Wanling Liang et al.   MOLECULAR PHARMACEUTICS

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

(2015) Panagiotis Mastorakos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

(2015) Shaopeng Yuan et al.   Science Translational Medicine

Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer

(2015) Caina Xu et al.   Small

Toxicity of Nanomaterials

(2015) Haseeb A. Khan et al.   Biomed Research International

Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying

(2015) Tomoyuki Okuda et al.   Pharmaceutics

siRNA Delivery to the lung: What's new?

(2014) Olivia M. Merkel et al.   ADVANCED DRUG DELIVERY REVIEWS

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

(2014) Ben Forbes et al.   ADVANCED DRUG DELIVERY REVIEWS

Gold Nanoparticles Stabilized with MPEG-Grafted Poly(l-lysine): in Vitro and in Vivo Evaluation of a Potential Theranostic Agent

(2014) Alexei A. Bogdanov et al.   BIOCONJUGATE CHEMISTRY

Spray freeze drying for dry powder inhalation of nanoparticles

(2014) Mohamed Ehab Ali et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Small Interfering RNAs Targeted to Interleukin-4 and Respiratory Syncytial Virus Reduce Airway Inflammation in a Mouse Model of Virus-Induced Asthma Exacerbation

(2014) Musa R. Khaitov et al.   HUMAN GENE THERAPY

Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

(2014) Yasmine M. Gabal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterization of a Reverse-Phase Perfluorocarbon Emulsion for the Pulmonary Delivery of Tobramycin

(2014) Ryan A. Orizondo et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Epithelial barrier function: At the front line of asthma immunology and allergic airway inflammation

(2014) Steve N. Georas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current issues of RNAi therapeutics delivery and development

(2014) D. Haussecker   JOURNAL OF CONTROLLED RELEASE

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

(2014) Jung Soo Suk et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic Aerosol Bioengineering of siRNA for the Treatment of Inflammatory Lung Disease by TNFα Gene Silencing in Macrophages

(2014) Ciara Kelly et al.   MOLECULAR PHARMACEUTICS

Poly(amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for siRNA Delivery to the Lung Epithelium

(2014) Denise S. Conti et al.   MOLECULAR PHARMACEUTICS

Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine

(2014) Hui Yi Xue et al.   Nanomedicine

Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases

(2014) Nitin Joshi et al.   Scientific Reports

Hypertonic Saline Is Effective in the Prevention and Treatment of Mucus Obstruction, but Not Airway Inflammation, in Mice with Chronic Obstructive Lung Disease

(2013) Simon Y. Graeber et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MicroRNA-326 Regulates Profibrotic Functions of Transforming Growth Factor-β in Pulmonary Fibrosis

(2013) Sudipta Das et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models

(2013) João Conde et al.   BIOMATERIALS

In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals

(2013) Kamrun Nahar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Low-Molecular-Weight Heparin (LMWH)–Loaded Large Porous PEG-PLGA Particles for the Treatment of Asthma

(2013) Brijeshkumar Patel et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Combined delivery of HMGB-1 box A peptide and S1PLyase siRNA in animal models of acute lung injury

(2013) Binna Oh et al.   JOURNAL OF CONTROLLED RELEASE

Receptor-Interacting Protein 2 Gene Silencing Attenuates Allergic Airway Inflammation

(2013) F. Y. Goh et al.   JOURNAL OF IMMUNOLOGY

Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host?

(2013) T. R. Hawn et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Enhanced Intrapulmonary Delivery of Anticancer siRNA for Lung Cancer Therapy Using Cationic Ethylphosphocholine-based Nanolipoplexes

(2013) Gayong Shim et al.   MOLECULAR THERAPY

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels

(2013) Lynn De Backer et al.   Nanomedicine

Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways

(2013) Yijuan Zhang et al.   Nanoscale

Effect of inhaled dry powder mannitol on mucus and its clearance

(2013) Evangelia Daviskas et al.   Expert Review of Respiratory Medicine

Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances

(2012) Shi Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

Chronic Bronchitis and Chronic Obstructive Pulmonary Disease

(2012) Victor Kim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Noncovalenly PEGylated CTGF siRNA/PDMAEMA complex for pulmonary treatment of bleomycin-induced lung fibrosis

(2012) Dong Kyung Sung et al.   BIOMATERIALS

Structure–function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins

(2012) Bárbara Olmeda et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

PEG–PLGA based large porous particles for pulmonary delivery of a highly soluble drug, low molecular weight heparin

(2012) Brijeshkumar Patel et al.   JOURNAL OF CONTROLLED RELEASE

An inhalable β2-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung

(2012) Yongfeng Luo et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated Polyplex With Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses

(2012) Satoshi Uchida et al.   MOLECULAR THERAPY

Nonviral Pulmonary Delivery of siRNA

(2011) Olivia M. Merkel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Pulmonary delivery of therapeutic siRNA

(2011) Jenny Ka-Wing Lam et al.   ADVANCED DRUG DELIVERY REVIEWS

Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 Short Interfering RNAs for Pulmonary Fibrosis

(2011) Corina N. D'Alessandro-Gabazza et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Gene Therapy for Allergic Airway Diseases

(2011) Tania Maes et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Altering the immune response with lipid-based nanoparticles

(2011) Dalit Landesman-Milo et al.   JOURNAL OF CONTROLLED RELEASE

Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

(2011) Ditte Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA

(2011) Oleh Taratula et al.   JOURNAL OF DRUG TARGETING

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

(2011) Jung Soo Suk et al.   MOLECULAR THERAPY

Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated withN-acetyl cysteine

(2011) Jung Soo Suk et al.   Nanomedicine

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

(2011) Adrian G. Rosas-Taraco et al.   TUBERCULOSIS

Chemical vectors for gene delivery: uptake and intracellular trafficking

(2010) Chantal Pichon et al.   CURRENT OPINION IN BIOTECHNOLOGY

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

(2009) Jung Soo Suk et al.   BIOMATERIALS

Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

(2009) Ditte Marie Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Nonviral siRNA Delivery to the Lung: Investigation of PEG−PEI Polyplexes and Their In Vivo Performance

(2009) Olivia M. Merkel et al.   MOLECULAR PHARMACEUTICS

Extracellular barriers in respiratory gene therapy

(2008) Niek Sanders et al.   ADVANCED DRUG DELIVERY REVIEWS

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation

(2008) Angela Haczku   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: In vivo deposition and hypoglycaemic activity after delivery to rat lungs

(2008) Francesca Ungaro et al.   JOURNAL OF CONTROLLED RELEASE