Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host?
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host?
Authors
Keywords
-
Journal
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Volume 77, Issue 4, Pages 608-627
Publisher
American Society for Microbiology
Online
2013-12-02
DOI
10.1128/mmbr.00032-13
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway
- (2014) S. R. Krutzik et al. JOURNAL OF IMMUNOLOGY
- Lipocalin 2-Dependent Inhibition of Mycobacterial Growth in Alveolar Epithelium
- (2014) H. Saiga et al. JOURNAL OF IMMUNOLOGY
- Zafirlukast Inhibits Complexation of Lsr2 with DNA and Growth of Mycobacterium tuberculosis
- (2013) Lucile Pinault et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
- (2013) Francisco J. Roca et al. CELL
- Antibody-Mediated Immunity against Tuberculosis: Implications for Vaccine Development
- (2013) Jacqueline M. Achkar et al. Cell Host & Microbe
- Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
- (2013) Cristina Vilaplana et al. JOURNAL OF INFECTIOUS DISEASES
- Nonsteroidal Antiinflammatory Drugs for Adjunctive Tuberculosis Treatment
- (2013) Juraj Ivanyi et al. JOURNAL OF INFECTIOUS DISEASES
- Adjuvant Host-Directed Therapy with Types 3 and 5 but Not Type 4 Phosphodiesterase Inhibitors Shortens the Duration of Tuberculosis Treatment
- (2013) Mamoudou Maiga et al. JOURNAL OF INFECTIOUS DISEASES
- Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis
- (2013) Ka-Wing Wong et al. JOURNAL OF INFECTIOUS DISEASES
- Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses
- (2013) R. M. B. Teles et al. SCIENCE
- Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo
- (2013) Teresa Repasy et al. PLoS Pathogens
- NET balancing: a problem in inflammatory lung diseases
- (2013) Olivia Z. Cheng et al. Frontiers in Immunology
- Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [18F]2-Fluoro-Deoxy-d-Glucose Positron Emission Tomography and Computed Tomography
- (2012) Laura E. Via et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections
- (2012) David M. Tobin et al. CELL
- Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway
- (2012) Robert O. Watson et al. CELL
- Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action
- (2012) Jwa-Jin Kim et al. Cell Host & Microbe
- Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages
- (2012) Paolo S. Manzanillo et al. Cell Host & Microbe
- Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages
- (2012) Chao-Tsung Yang et al. Cell Host & Microbe
- Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype
- (2012) Varshneya Singh et al. Cell Host & Microbe
- Corticosteroid Resistance and Novel Anti-Inflammatory Therapies in Chronic Obstructive Pulmonary Disease
- (2012) Amir Hakim et al. DRUGS
- Curcumin: a potential candidate for matrix metalloproteinase inhibitors
- (2012) Dileep Kumar et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
- (2012) Manohar Pilli et al. IMMUNITY
- Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacterium tuberculosis in Human Macrophages
- (2012) H. Bruns et al. JOURNAL OF IMMUNOLOGY
- Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity
- (2012) M. J. Kaplan et al. JOURNAL OF IMMUNOLOGY
- Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPAR and TR4 for Survival
- (2012) S. Mahajan et al. JOURNAL OF IMMUNOLOGY
- The regulation of fibrosis in airway remodeling in asthma
- (2012) Simon G. Royce et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Autophagy modulation as a potential therapeutic target for diverse diseases
- (2012) David C. Rubinsztein et al. NATURE REVIEWS DRUG DISCOVERY
- Successful Shortening of Tuberculosis Treatment Using Adjuvant Host-Directed Therapy with FDA-Approved Phosphodiesterase Inhibitors in the Mouse Model
- (2012) Mamoudou Maiga et al. PLoS One
- Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R
- (2012) Kangyun Wu et al. PLoS One
- Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment
- (2012) A. K. Coussens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection
- (2012) E. Greco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials
- (2012) B. Gold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of autophagy in host defence against Mycobacterium tuberculosis infection
- (2012) Mário Songane et al. TUBERCULOSIS
- PPARγExpression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing
- (2012) Patricia E. Almeida et al. PPAR Research
- Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis
- (2012) Karen K. Y. Lam et al. PLoS Pathogens
- Immune Interference inMycobacterium tuberculosisIntracellular Iron Acquisition through Siderocalin Recognition of Carboxymycobactins
- (2011) Trisha M. Hoette et al. ACS Chemical Biology
- Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology
- (2011) Selvakumar Subbian et al. AMERICAN JOURNAL OF PATHOLOGY
- Identification of new inhibitors of protein kinase R guided by statistical modeling
- (2011) Ruslana Bryk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis
- (2011) Ruth J. Napier et al. Cell Host & Microbe
- Mycobacterium tuberculosis and the intimate discourse of a chronic infection
- (2011) David G. Russell IMMUNOLOGICAL REVIEWS
- Autophagy in immunity and cell-autonomous defense against intracellular microbes
- (2011) Vojo Deretic IMMUNOLOGICAL REVIEWS
- The Role of Aspirin in Childhood Tuberculous Meningitis
- (2011) Johan F. Schoeman et al. JOURNAL OF CHILD NEUROLOGY
- MMP-1 drives immunopathology in human tuberculosis and transgenic mice
- (2011) Paul Elkington et al. JOURNAL OF CLINICAL INVESTIGATION
- Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators
- (2011) E. L. Campbell et al. JOURNAL OF IMMUNOLOGY
- High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial
- (2011) Adrian R Martineau et al. LANCET
- Iron metabolism and the innate immune response to infection
- (2011) Erin E. Johnson et al. MICROBES AND INFECTION
- The role of IL-10 in immune regulation during M. tuberculosis infection
- (2011) P S Redford et al. Mucosal Immunology
- Antibacterial effects of vitamin D
- (2011) Martin Hewison Nature Reviews Endocrinology
- SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis
- (2011) XiangWei Li et al. PLoS One
- Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice
- (2011) Mi-Sun Koo et al. PLoS One
- A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection
- (2011) B.-H. Kim et al. SCIENCE
- Vitamin D Is Required for IFN- -Mediated Antimicrobial Activity of Human Macrophages
- (2011) M. Fabri et al. Science Translational Medicine
- Neutrophils in tuberculosis: friend or foe?
- (2011) David M. Lowe et al. TRENDS IN IMMUNOLOGY
- Mycobacterium tuberculosis components stimulate production of the antimicrobial peptide hepcidin
- (2011) Fatoumata B. Sow et al. TUBERCULOSIS
- Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology
- (2011) Kerry J. Welsh et al. TUBERCULOSIS
- Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs
- (2011) Selvakumar Subbian et al. PLoS Pathogens
- The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans
- (2010) David M. Tobin et al. CELL
- Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis
- (2010) Dhiraj Kumar et al. CELL
- Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung
- (2010) Paul S. Redford et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement
- (2010) I. Solovic et al. EUROPEAN RESPIRATORY JOURNAL
- Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties
- (2010) Marisa Ponpuak et al. IMMUNITY
- Role of Ferroportin in Macrophage-Mediated Immunity
- (2010) E. E. Johnson et al. INFECTION AND IMMUNITY
- Guanosine triphosphatases as novel therapeutic targets in tuberculosis
- (2010) Rajni et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
- (2010) Lis R.V. Antonelli et al. JOURNAL OF CLINICAL INVESTIGATION
- Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor Linking Mannose Receptor Recognition to Regulation of Immune Responses
- (2010) M. V. S. Rajaram et al. JOURNAL OF IMMUNOLOGY
- IntracellularMycobacterium aviumIntersect Transferrin in the Rab11+Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway
- (2010) Øyvind Halaas et al. JOURNAL OF INFECTIOUS DISEASES
- Role of aspirin in tuberculous meningitis: A randomized open label placebo controlled trial
- (2010) U.K. Misra et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis
- (2010) Maziar Divangahi et al. NATURE IMMUNOLOGY
- Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?
- (2010) Samuel M. Behar et al. NATURE REVIEWS MICROBIOLOGY
- Tuberculosis: What We Don't Know Can, and Does, Hurt Us
- (2010) D. G. Russell et al. SCIENCE
- Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects
- (2010) James Curtis et al. TUBERCULOSIS
- Identification of Host-Dependent Survival Factors for Intracellular Mycobacterium tuberculosis through an siRNA Screen
- (2010) Shilpi Jayaswal et al. PLoS Pathogens
- Vitamin D as Supplementary Treatment for Tuberculosis
- (2009) Christian Wejse et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Autophagy, Redox Signaling, and Ventricular Remodeling
- (2009) Narasimman Gurusamy et al. ANTIOXIDANTS & REDOX SIGNALING
- Reciprocal responsiveness to interleukin-12 and interferon- specifies human CD8+ effector versus central memory T-cell fates
- (2009) H. J. Ramos et al. BLOOD
- The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection
- (2009) J. Muse Davis et al. CELL
- Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin
- (2009) Jae-Min Yuk et al. Cell Host & Microbe
- CpG oligodeoxynucleotides promote phospholipase D dependent phagolysosome maturation and intracellular mycobacterial killing in M. tuberculosis infected type II alveolar epithelial cells
- (2009) Emanuela Greco et al. CELLULAR IMMUNOLOGY
- Mycobacterial survival strategies in the phagosome: defence against host stresses
- (2009) Sabine Ehrt et al. CELLULAR MICROBIOLOGY
- Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB
- (2009) Seok-Yong Eum et al. CHEST
- Effect of 1, 25 dihydroxyvitamin D3 on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis
- (2009) S. Prabhu Anand et al. CLINICAL IMMUNOLOGY
- Targeting Matrix Metalloproteinases in Inflammatory Conditions
- (2009) A. Clutterbuck et al. CURRENT DRUG TARGETS
- Vitamin D for Treatment and Prevention of Infectious Diseases: A Systematic Review of Randomized Controlled Trials
- (2009) Alexandra Yamshchikov et al. Endocrine Practice
- PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease
- (2009) Milena Morel et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
- (2009) Hannelie Korf et al. JOURNAL OF CLINICAL INVESTIGATION
- Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
- (2009) Eri Ishikawa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mycobacterium bovis Bacillus Calmette-Guerin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis
- (2009) P. E. Almeida et al. JOURNAL OF IMMUNOLOGY
- Role of STAT1, NF-κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-γ
- (2009) Fatoumata B. Sow et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Nitazoxanide Kills Replicating and NonreplicatingMycobacterium tuberculosisand Evades Resistance
- (2009) Luiz Pedro S. de Carvalho et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Potential Targets to Modulate Neutrophil Function in Inflammation
- (2009) R. Burgos et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase
- (2009) Nisheeth Agarwal et al. NATURE
- Dexamethasone, Cerebrospinal Fluid Matrix Metalloproteinase Concentrations and Clinical Outcomes in Tuberculous Meningitis
- (2009) Justin A. Green et al. PLoS One
- Immunomodulation with Recombinant Interferon-γ1b in Pulmonary Tuberculosis
- (2009) Rod Dawson et al. PLoS One
- Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium
- (2009) H. E. Volkman et al. SCIENCE
- Relaxin and its role in the development and treatment of fibrosis
- (2009) Robert G. Bennett Translational Research
- P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection
- (2009) Alan G. Goodman et al. PLoS Pathogens
- Adjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: A randomized, double-blind, placebo-controlled study
- (2008) María T Milanés-Virelles et al. BMC INFECTIOUS DISEASES
- Airway Remodeling Measured by Multidetector CT Is Increased in Severe Asthma and Correlates With Pathology
- (2008) Ravi S. Aysola et al. CHEST
- Role of C-Type Lectins in Mycobacterial Infections
- (2008) L. Schlesinger et al. CURRENT DRUG TARGETS
- Interaction of TGF-β with Immune Cells in Airway Disease
- (2008) Benjamin Moore et al. CURRENT MOLECULAR MEDICINE
- Human macrophage host defense against Mycobacterium tuberculosis
- (2008) Philip T Liu et al. CURRENT OPINION IN IMMUNOLOGY
- 1α,25-dihydroxyvitamin D3inhibits matrix metalloproteinases induced byMycobacterium tuberculosisinfection
- (2008) Anna Coussens et al. IMMUNOLOGY
- Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
- (2008) Franca Gerosa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death
- (2008) Minjian Chen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
- (2008) Elisabetta Volpe et al. NATURE IMMUNOLOGY
- The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
- (2008) Nicolas Manel et al. NATURE IMMUNOLOGY
- Neutrophil extracellular traps are induced by Mycobacterium tuberculosis
- (2008) Victoria Ramos-Kichik et al. TUBERCULOSIS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation