Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine

Systemic delivery of siRNA via targeted nanoparticles in patients with cancer: Results from a first-in-class phase I clinical trial.

(2017) A. Ribas et al.   JOURNAL OF CLINICAL ONCOLOGY

siRNA

(2013) Indu Pal Kaur et al.   BIODRUGS

Engineered Inorganic Nanoparticles for Drug Delivery Applications

(2013) Isaac Ojea-Jimenez et al.   CURRENT DRUG METABOLISM

siRNA delivery: from basics to therapeutic applications

(2013) Vladimir Torchilin   Frontiers in Bioscience-Landmark

Endosomal escape kinetics of mesoporous silica-based system for efficient siRNA delivery

(2013) Mingqi Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Complement C2 siRNA mediated therapy of myasthenia gravis in mice

(2013) Ruksana Huda et al.   JOURNAL OF AUTOIMMUNITY

Recent advances in theranostic nanocarriers of doxorubicin based on iron oxide and gold nanoparticles

(2013) J. Gautier et al.   JOURNAL OF CONTROLLED RELEASE

Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery

(2013) Shan Jiang et al.   NANO LETTERS

Biomedical applications of nanodiamonds in imaging and therapy

(2013) Elena Perevedentseva et al.   Nanomedicine

siRNA-based nanomedicine

(2013) Jing Zhao et al.   Nanomedicine

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

(2013) Frank Iversen et al.   Theranostics

Understanding the Toxicity of Carbon Nanotubes

(2012) Ying Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions

(2012) Borja Ballarín-González et al.   ADVANCED DRUG DELIVERY REVIEWS

RNAi-based nanomedicines for targeted personalized therapy

(2012) Ala Daka et al.   ADVANCED DRUG DELIVERY REVIEWS

Real-time quantification of antibody–short interfering RNA conjugate in serum by antigen capture reverse transcription–polymerase chain reaction

(2012) Martha Tan et al.   ANALYTICAL BIOCHEMISTRY

Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery

(2012) Amir Abbas Mokhtarieh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A review of nanocarriers for the delivery of small interfering RNA

(2012) Prashant Kesharwani et al.   BIOMATERIALS

Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application

(2012) Michael Jäger et al.   CHEMICAL SOCIETY REVIEWS

Co-delivery Strategies Based on Multifunctional Nanocarriers for Cancer Therapy

(2012) Hao Chen et al.   CURRENT DRUG METABOLISM

RNA Interference for Viral Infections

(2012) Stephen J. Blake et al.   CURRENT DRUG TARGETS

Targeting megalin to enhance delivery of anti-clusterin small-interfering RNA nanomedicine to chemo-treated breast cancer

(2012) Hui Yi Xue et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling

(2012) Eric C. Freeman et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Lipid Encapsulation of Cationic Polymers in Hybrid Nanocarriers Reduces Their Non-Specific Toxicity to Breast Epithelial Cells

(2012) Hui Yi Xue et al.   PHARMACEUTICAL RESEARCH

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation

(2012) Dan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layer-by-Layer Coated Gold Nanoparticles: Size-Dependent Delivery of DNA into Cells

(2012) Asmaa Elbakry et al.   Small

siRNA Transfection with Calcium Phosphate Nanoparticles Stabilized with PEGylated Chelators

(2012) Elisabeth V. Giger et al.   Advanced Healthcare Materials

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

(2012) Tatiana I Novobrantseva et al.   Molecular Therapy-Nucleic Acids

Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy

(2011) Carlos Tassa et al.   ACCOUNTS OF CHEMICAL RESEARCH

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Solid Lipid–PEI Hybrid Nanocarrier: An Integrated Approach To Provide Extended, Targeted, and Safer siRNA Therapy of Prostate Cancer in an All-in-One Manner

(2011) Hui-Yi Xue et al.   ACS Nano

Tailoring nanostructured solid-lipid carriers for time-controlled intracellular siRNA kinetics to sustain RNAi-mediated chemosensitization

(2011) Hui Yi Xue et al.   BIOMATERIALS

Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice

(2011) Andrea Beyerle et al.   BIOMATERIALS

SiRNA delivery with functionalized carbon nanotubes

(2011) Amir Khashayar Varkouhi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells

(2011) Tamotsu Tsukahara et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Surface charge of gold nanoparticles mediates mechanism of toxicity

(2011) Nicole M. Schaeublin et al.   Nanoscale

Nanotoxicology and in vitro studies: The need of the hour

(2011) Sumit Arora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Polymers in Small-Interfering RNA Delivery

(2011) Kaushik Singha et al.   Nucleic Acid Therapeutics

Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte

(2010) Shutao Guo et al.   ACS Nano

Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics

(2010) Saghir Akhtar   Expert Opinion on Drug Metabolism & Toxicology

Chitosan as a carrier for targeted delivery of small interfering RNA

(2010) Walter E. Rudzinski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers

(2010) Riccardo Muzzarelli   Marine Drugs

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Efficient Gene Silencing in Lungs and Liver Using Imidazole-Modified Chitosan As a Nanocarrier for Small Interfering RNA

(2010) Bilal Ghosn et al.   OLIGONUCLEOTIDES

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbon Nanotubes in Animal Models: A Systematic Review on Toxic Potential

(2010) Meike van der Zande et al.   TISSUE ENGINEERING PART B-REVIEWS

Multifunctional Nanomedicine Platform for Cancer Specific Delivery of siRNA by Superparamagnetic Iron Oxide Nanoparticles-Dendrimer Complexes

(2010) Oleh Taratula et al.   Current Drug Delivery

Targeted Delivery Systems for Oligonucleotide Therapeutics

(2009) Bo Yu et al.   AAPS Journal

Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone

(2009) C. Moreira et al.   Acta Biomaterialia

The suppression of lung tumorigenesis by aerosol-delivered folate–chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway

(2009) Hu-Lin Jiang et al.   BIOMATERIALS

Minireview: Nanoparticles and the Immune System

(2009) Banu S. Zolnik et al.   ENDOCRINOLOGY

Effect of homobifunctional crosslinkers on nucleic acids delivery ability of PEI nanoparticles

(2009) Archana Swami et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment of the In Vivo Toxicity of Gold Nanoparticles

(2009) Yu-Shiun Chen et al.   Nanoscale Research Letters

A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery

(2009) Yoshihisa Namiki et al.   Nature Nanotechnology

Emerging Pharmacologic Therapies for Wet Age-Related Macular Degeneration

(2009) Zhang Ni et al.   OPHTHALMOLOGICA

Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects

(2009) Alaaldin M. Alkilany et al.   Small

Poly(β-amino ester) as a carrier for si/shRNA delivery in lung cancer cells

(2008) Dhananjay Jere et al.   BIOMATERIALS

Maintaining the silence: reflections on long-term RNAi

(2008) Koen Raemdonck et al.   DRUG DISCOVERY TODAY

Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells

(2008) Maricica Pacurari et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Systemic Delivery of DNA or siRNA Mediated by Linear Polyethylenimine (L-PEI) Does Not Induce an Inflammatory Response

(2008) Marie-Elise Bonnet et al.   PHARMACEUTICAL RESEARCH

Delivery of siRNA from lyophilized polymeric surfaces

(2007) Morten Ø. Andersen et al.   BIOMATERIALS

Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery

(2007) Chao Lin et al.   JOURNAL OF CONTROLLED RELEASE